The ultrasound-assisted synthesis of some novel fused-ring heterocyclic systems bearing structurally diverse benzazoles via a copper-catalyzed cross-coupling reaction was written by Karimi, Nafiseh;Mahboubi-Rabbani, Mohammad;Dastjerdi, Hossein Fasihi;Nematpour, Manijeh;Rezaee, Elham;Tabatabai, Sayyed Abbas. And the article was included in Monatshefte fuer Chemie in 2022.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:
A novel ultrasonic-assisted process involving CuI-catalyzed intra-mol. C-H activation of benzazoles were developed. This methodol. offered affordable starting materials, mild reaction conditions, easy handling of the catalyst, a simple work-up process and short reaction times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem