Oxone-DMSO Triggered Methylene Insertion and C(sp2)-C(sp3)-H-C(sp2) Bond Formation to Access Functional Bis-Heterocycles was written by Kour, Jaspreet;Venkateswarlu, Vunnam;Verma, Praveen K.;Hussain, Yaseen;Dubey, Gurudutt;Bharatam, Prasad V.;Sahoo, Subash C.;Sawant, Sanghapal D.. And the article was included in Journal of Organic Chemistry in 2020.Reference of 1632-83-3 This article mentions the following:
Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)-C(sp3)-H-C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included exptl. study and DFT calculations, and various sym. and unsym. bis-pyrazoles as well as other pyrazole-based bis-heterocyclic mols. were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsym. pyrazoles generated a chiral center to extend the scope of this method. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 1632-83-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem