Formulation development & evaluation of candesartan cilexetil mucoadhesive buccal films was written by Kumari, K. Prema;Malyadri, T.;Sreenivasaprasana, P.. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2019.Synthetic Route of C33H34N6O6 This article mentions the following:
Candesartan cilexetil useful in the tretament of hypertension having Angiotensin II receptor antagonist activity Buccoadhesive films of candesartan were prepared by solvent-casting method using novel polymers to improve the efficacy and bioavailability than the conventional formulations. The Prepared buccal films were evaluated for their weight, thickness, surface pH, swelling index, drug content uniformity, in vitro residence time, folding endurance in vitro release and permeation studies. the formulation C11 contain polyox to prepare sustained release mucoadhesive films of Candesartan as this formulation retards the release rate upto 8hrs and at the end of 8 h the release rate was found to be highest (i.e., 99.6%). Formulation C11showed good swelling, a convenient residence time and promising extended drug release, which can be selected for the development of buccal film for effective therapeutic use. The data observed from this study highlight the feasibility of the buccal route as a viable option for delivery of candesartan cilexetil. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Synthetic Route of C33H34N6O6).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C33H34N6O6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem