Chlorodifluoromethane as a C1 Synthon in the Assembly of N-Containing Compounds was written by Ma, Xingxing;Su, Jianke;Zhang, Xingang;Song, Qiuling. And the article was included in iScience in 2019.Electric Literature of C8H8N2 This article mentions the following:
A quadruple cleavage of chlorodifluoromethane to yield a C1 source, which was successfully employed in the construction of various N-containing compounds e.g., C6H5N(CH3)CH=NC6H5 especially with pharmaceutical mols. under mild conditions was reported. This strategy provides a useful method for late-stage modification of pharmaceutical compounds Four bonds in ClCF2H were orderly cleaved under basic conditions in the absence of transition metals. Preliminary mechanistic studies revealed that (E)-N-phenylformimidoyl fluoride intermediate is involved in this process by in situ 1H NMR studies and control experiments In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem