B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase was written by Meguellati, Amel;Ahmed-Belkacem, Abdelhakim;Yi, Wei;Haudecoeur, Romain;Crouillere, Marie;Brillet, Rozenn;Pawlotsky, Jean-Michel;Boumendjel, Ahcene;Peuchmaur, Marine. And the article was included in European Journal of Medicinal Chemistry in 2014.Related Products of 58442-17-4 This article mentions the following:
Following our recent report showing the potential of naturally occurring aurones (2-benzylidenebenzofuran-3(2H)-ones) as anti-hepatitis C virus (HCV) agents, efforts were continued in order to refine the structural requirements for the inhibitory effect on HCV RNA-dependent RNA polymerase (RdRp). In this study, we targeted the B-ring moiety of aurones with the aim to improve structural features associated with higher inhibition of the targeted polymerase. In vitro evaluation of the RdRp inhibitory activity of the 37 newly synthesized compounds pointed out that the replacement of the B-ring with an N-substituted indole moiety induced the highest inhibitory effect. Of these, compounds 31, 40 and 41 were found to be the most active (IC50 = 2.3-2.4 μM). Docking experiments performed with the most active compounds revealed that the allosteric thumb pocket I of RdRp is the binding pocket for aurone analogs. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4Related Products of 58442-17-4).
1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 58442-17-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem