Transformations of sugars in an ammoniacal medium was written by Parrod, Jacques. And the article was included in Annali di Chimica Applicata in 1933.Computed Properties of C4H5N3O This article mentions the following:
P. bubbled air through an aqueous solution containing levulose, NH4OH and the hydroxide or sulphate of a metal (CaO, ZnO, FeSO4, Fe2(SO4)3 or MnSO4) for 1 month at ordinary temperature; 4-methylimidazole was formed in all cases and 4-hydroxymethylimidazole in all cases except with CaO. In a repetition of the experiment without air the product was 4-methylimidazole in all cases, but in poor yields except with ZnO; in the single case with MnSO4 there was also formed 2-hydroxymethyl-4-methylimidazole, C5H8ON2, coarse needles, m. 129°; picrate, m. 82°. In a 2nd experiment with air a solution containing levulose, NH4HCO3 and Cu(OH)2, oxalic acid and imidazoles were found among the reaction products. In a 3rd similar experiment with air, levulose was oxidized with methylene blue in the presence of NH4OH; the products included 4-hydroxymethylimidazole, (d-arabino)-4-tetrahydroxybutylimidazole, and a new substance 4-imidazoleformamide, N:CH.NH.CH:CCONH2.H2O, large colorless efflorescent crystals, m. 214°; HCl salt, large prisms, m. 220°, picrate, yellow needles, m. 208°. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Computed Properties of C4H5N3O).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C4H5N3O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem