Copper-mediated oxidative cyclization of heterocyclically substituted aldimines was written by Pufky-Heinrich, Daniela;Ciesielski, Michael;Gharnati, Loubna;Walter, Olaf;Doering, Manfred. And the article was included in Heterocycles in 2010.Product Details of 85692-37-1 This article mentions the following:
Cu-mediated cascade reactions were performed with heteroaryl aldimines. These oxidative heterocyclizations include sequences of oxidations and cycloadditions or nucleophilic additions, which take place in the coordination sphere of Cu ions. When 2 heteroaryl aldimines were reacted in the presence of Cu(II) under air, pyridines were produced. In one case, a 5,8-di-1H-imidazol-2-yl-3,7-dipyridin-2-yl-1,4-diazatricyclo[3.2.1.02,7]oct-3-ene was also formed. The basic structure of this new tetracyclic compound contains 5 new chiral C atoms. Its cage-like structure was revealed by x-ray crystallog. [orthorhombic, space group Pna(2), a 20.2315(15), b 10.0265(7), c 11.2033(8) Å, V 2272.6(3) Å3, Z 4]. The synthesis of 2H-pyrroles by Cu-assisted conversions of the aldimines with acetylenedicarboxylate or quinones was also described. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Product Details of 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem