Regioselective allenylation and propargylation of various para-quinone methides using alkynyl azaarenes as pronucleophiles was written by Rayaroth, Amritha;Elikkottil, Afna;Mohan Jayakumari, Chithra;Arayil Vennoli, Kalyanakrishnan;Vennapusa, Sivaranjana Reddy;Kaliyamoorthy, Alagiri. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
Bronsted base-mediated regioselective allenylation and propargylation of various para-quinone methides using unfunctionalized 2-alkynyl azaarenes as pronucleophiles was developed. The appropriate choice of a base provided an opportunity to achieve either an allenylated product or the propargylated product. The use of KOtBu as a Bronsted base promoted the formation of allenylated products, whereas NaN(SiMe3)2 furnished the propargylated products. Besides, the strategy was scalable and could be performed on a gram scale. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem