Asymmetric Allylic C-H Alkylation of Allyl Ethers with 2-Acylimidazoles was written by Wang, Tian-Ci;Fan, Lian-Feng;Shen, Yang;Wang, Pu-Sheng;Gong, Liu-Zhu. And the article was included in Journal of the American Chemical Society in 2019.Formula: C6H8N2O This article mentions the following:
An asym. allylic C-H alkylation of allyl ethers has been established by chiral phosphoramidite-palladium catalysis, affording a wide variety of functionalized chiral 2-acylimidazoles in moderate to high yields and with high levels of enantioselectivity. Moreover, this protocol could be applied to a concise asym. synthesis of a tachykinin receptor antagonist. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C6H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem