Williams, A. et al. published their research in Journal of the Chemical Society in 1972 | CAS: 4887-83-6

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Category: imidazoles-derivatives

Proteolytic enzymes. Models for electrophilic assistance by NH in acylation was written by Williams, A.;Salvadori, G.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.Category: imidazoles-derivatives This article mentions the following:

The effect of increasing dioxane content of the medium was used to examine the possibility of intramol. electrophilic assistance by NH in alk. hydrolysis of the Me esters of 2-acetamidobenzoic, 2-pyrrolecarboxylic (I), and benzimidazole-4(7)-carboxylic (II) acids. Significant rate constant enhancement was observed for positional isomers where participation was possible; enhancements increased rapidly with increasing dioxane concentration, thus agreeing with a built-in solvation by NH of the incipient alkoxide ion (derived from the carbonyl O) of the transition state. I and II had maximum in their rate enhancements as the dioxane content increased. The NH to alkoxide bond distance in I and II is larger than normally found for direct H-bonding and the maximum may arise from a H2O bridge acting as a relay between electrophilic NH and incipient alkoxide ion in the transition state. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Category: imidazoles-derivatives).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem