Month: January 2023

Nickel-Catalyzed Reductive Alkylation of Heteroaryl Imines was written by Turro, Raymond F.;Brandstatter, Marco;Reisman, Sarah E.. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

The preparation of heterobenzylic amines, e.g., I [R¹ = H, 4-Cl, 5-F, 6-Me, etc.; R² = i-Pr, n-Bu, t-Bu, cyclopropyl, cyclobutyl, (R)-PhCHMe; R³ = H, Me, R⁴ = PhCH₂; R³ = H, R⁴ = 4-ClC₆H₄CH₂, 2,6-Me₂C₆H₃CH₂, etc.; R³R⁴ = (CH₂)₂X(CH₂)₂; X = CH₂, O, CO, NBoc], by a Ni-catalyzed reductive cross-coupling between heteroaryl imines, e.g., II, and C(sp³) electrophiles R³R⁴CHX¹ (X¹ = Cl, Br, I, phthalimidyloxycarbonyl) is reported. This umpolung-type alkylation proceeds under mild conditions, avoids the pre-generation of organometallic reagents, and exhibits good functional group tolerance. Mechanistic studies are consistent with the imine substrate acting as a redox-active ligand upon coordination to a low-valent Ni center. The resulting bis(2-imino)heterocycle·Ni complexes can engage in alkylation reactions with a variety of C(sp³) electrophiles, giving heterobenzylic amine products in good yields. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Halometallate Complexes of Germanium(II) and (IV): Probing the Role of Cation, Oxidation State and Halide on the Structural and Electrochemical Properties was written by Bartlett, Philip N.;Cummings, Charles Y.;Levason, William;Pugh, David;Reid, Gillian. And the article was included in Chemistry – A European Journal in 2014.Related Products of 92507-97-6 This article mentions the following:

The Ge^IV chlorometalate complexes, [EMIM]₂[GeCl₆], [EDMIM]₂[GeCl₆] and [PYRR]₂[GeCl₆] (EMIM = 1-ethyl-3-methylimidazolium; EDMIM = 2,3-dimethyl-1-ethylimidazolium; PYRR = N-butyl-N-methylpyrrolidinium) have been synthesized and fully characterized; the first two also by single-crystal x-ray diffraction. The imidazolium chlorometallates exhibited significant C-H···Cl hydrogen bonds, resulting in extended supramol. assemblies in the solid state. Solution ¹H NMR data also showed cation-anion association The synthesis and characterization of Ge^II halometalate salts [EMIM][GeX₃] (X = Cl, Br, I) and [PYRR][GeCl₃], including single-crystal x-ray analyses for the homologous series of imidazolium salts, are reported. In these complexes, the intermol. interactions are much weaker in the solid state and they appear not to be significantly associated in solution Cyclic-voltammetry experiments on the Ge^IV species in CH₂Cl₂ solution showed two distinct, irreversible reduction waves attributed to Ge^IV-Ge^II and Ge^II-Ge⁰, whereas the Ge^II species exhibited one irreversible reduction wave. The potential for the Ge^II-Ge⁰ reduction was unaffected by changing the cation, although altering the oxidation state of the precursor from Ge^IV to Ge^II does have an effect; for a given cation, reduction from the [GeCl₃]^– salts occurred at a less cathodic potential. The nature of the halide co-ligand also has a marked influence on the reduction potential for the Ge^II-Ge⁰ couple, such that the reduction potentials for the [GeX₃]^– salts become significantly less cathodic when the halide (X) is changed Cl→Br→I. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Related Products of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficial in Drug Delivery 2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules was written by Christodoulou, Eirini;Ntountaniotis, Dimitrios;Leonis, Georgios;Mavromoustakos, Thomas;Valsami, Georgia. And the article was included in Methods in Molecular Biology (New York, NY, United States) in 2021.Product Details of 145040-37-5 This article mentions the following:

Bioavailability of active substances is of great importance for the formulation of a drug product, as it actually reflects drug absorption and achievement of the optimum pharmacol. effect. A great number of chem. compounds with excellent pharmacol. properties possess low solubility and permeability values, ending in low bioavailability in the human body after administration (especially after per os administration). CDs are oligosaccharides that possess biol. properties similar to their linear counterparts, but some of their physicochem. properties differ. They are enhancing bioavailability and solving problems of absorption for poorly soluble lipophilic drugs by forming water-soluble inclusion complexes. For this reason, they are widely used in drug delivery systems (Carrier et al. J Control Release 123:78-99, 2007; Kurkov and Loftsson, Int J Pharm 453:167-80, 2013). The main purpose of this chapter is to show a protocol for the preparation of drug:CDcomplex delivery systems. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines was written by Wu, Yue;Guo, Peng;Chen, Long;Duan, Weijie;Yang, Zengzhuan;Wang, Tao;Chen, Ting;Xiong, Fei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.COA of Formula: C8H8N2 This article mentions the following:

The direct formylation of benzothiazoles and isoquinolines was reported. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using com. available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction was performed under exceedingly mild reaction conditions and exhibited broad functional group tolerance. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvatochromism of Heteroaromatic Compounds: XIV. 5-Amino-1-methyl-4-nitropyrazole and Its Analogs was written by Vokin, A. I.;Shulunova, A. M.;Krivoruchka, I. G.;Krylova, O. V.;Lopyrev, V. A.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2002.Application In Synthesis of 1-Methyl-4-nitroimidazole This article mentions the following:

The solvatochromism of H complexes of 5-amino-1-methyl-4-nitropyrazole and 2-nitroaniline derivatives in aprotic protophilic media was described on a quant. level with the aid of Kamlet-Taft empirical parameters. Specific solvation affects only one of the two long-wave bands, that corresponding to an electronic transition involving orbital electron d. transfer from the H-bound N atom. When such transfer does not occur, which is typical of the second transition, specific solvatochromic effect is either weak or absent. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application In Synthesis of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Umpolung (3+2) Cycloadditions of Iminoesters with α,β-Unsaturated-2-acyl Imidazoles for the Synthesis of Substituted Pyrrolidines was written by Gill, Mamta;Das, Arko;Singh, Vinod K.. And the article was included in Organic Letters in 2022.Computed Properties of C6H8N2O This article mentions the following:

An enantioselective (3+2) cycloaddition reaction of iminoesters occurring with opposite regioselectivity was reported. This reaction provided chiral polysubstituted pyrrolidines with high enantioselectivities (up to 97%), diastereoselectivities (>20:1), and yields (up to 99%). Interestingly, changing the alpha-substituents of the iminoesters from an aryl to an aliphatic (benzyl) group or hydrogen resulted in the formation of normal (3+2) cycloaddition products, also in excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancing the solar energy conversion and harvesting characteristics of multiwalled carbon nanotubes-modified 1-hexyl-3-methyl-imidazolium cation ionic liquids was written by Boldoo, Tsogtbilegt;Lee, Minjung;Cho, Honghyun. And the article was included in International Journal of Energy Research in 2022.COA of Formula: C18H31F6N3O4S2 This article mentions the following:

The concept of solar energy absorption or photothermal energy conversion of nanofluids as a working fluid is a promising idea utilized in various applications. However, the lack of diversity of the base agents restricts the usage of solar thermal conversion systems in extreme conditions such as extreme cold or hot environments. The ionic liquids were used as a base agent to broaden the applicable conditions of the solar thermal conversion system considering the remarkable favorable characteristics of ionic liquids In this study, key factors of solar energy conversion characteristics and performance of the various 1-hexyl-3-methylimidazolium cation-based ionic liquids and MWCNT nanoparticle-enhanced ionic liquids (NEILs) were exptl. investigated. This study dives deep into the optical properties of the ionic liquids compared to the previous studies in the open literature. In the manufacturing process, MWCNT nanoparticles are dispersed in various ionic liquids at 20 kHz and coated with the Gum-Arabic. It was found that 1-hexyl-3-methylimidazolium cation-based pure room temperature ionic liquids were almost transparent in the visible light spectrum with nearly 0% absorbance; however, adding a small amount of addnl. MWCNT nanoparticles sharply increased the absorbance rate up to nearly 100% (Fâˆ?). Besides, the transmittance of the MWCNT NEILs decreased with the increasing concentration Under the simulated solar light, the final temperature of the samples increased with the increasing concentration of MWCNT NEIL. Moreover, the maximum photothermal energy conversion efficiency (η_PEC) of each MWCNT NEILs was 38.0%, 40.9%, 40.2%, and 39.8% in the case of [HMIM][Tf₂N], [HMIM][TfO], [HMIM][Pf₆], and [C₁₂MIM][Tf₂N], resp., at a concentration and operating time of 1 wt% and 7200 s. In addition, SER value sharply increased with the increasing nanoparticle concentration, and it almost doubled compared to the base agents. Furthermore, the nanoparticle concentration affects the solar energy absorption capability of ionic liquids more than anions in their chem. structure. This study can deliver the necessary data to design a direct absorption solar thermal collector using ionic liquids, which are new green designer working fluids. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5COA of Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly Efficient SO₂ Absorption and Its Subsequent Utilization by Weak Base/Polyethylene Glycol Binary System was written by Yang, Zhen-Zhen;He, Liang-Nian;Zhao, Ya-Nan;Yu, Bing. And the article was included in Environmental Science & Technology in 2013.Formula: C11H20N2 This article mentions the following:

A binary system consisting of polyethylene glycol (PEG, proton donor)/PEG-functionalized base with suitable basicity was developed for efficient gas desulfurization (GDS) and is regarded as an alternative approach to circumvent the energy penalty problem in the GDS process. High capacity for SO₂ capture (â‰?.88 mol SO₂/mol base) was achieved, even under low SO₂ partial pressure. SO₂ desorption operates smoothly under mild conditions (N₂, 25°); no significant drop in SO₂ absorption was observed after 5 successive absorption/desorption cycles. SO₂ absorbed by PEG₁₅₀MeIm/PEG₁₅₀, considered the activated form of SO₂, can be directly transformed into value-added chems. under mild conditions, eliminating the energy penalty for SO₂ desorption and simultaneously recycling the absorbents. Thus, this SO₂ capture and utilization process offers an alternative way for GDS and potentially enables SO₂ conversion from flue gas to useful chems. as a value-added process. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polymer inclusion membranes (PIMs) doped with alkylimidazole and their application in the separation of non-ferrous metal ions was written by Radzyminska-Lenarcik, Elzbieta;Ulewicz, Malgorzata. And the article was included in Polymers (Basel, Switzerland) in 2019.Related Products of 21252-69-7 This article mentions the following:

The study involved the transport of zinc(II), cadmium(II), and nickel(II) ions from acidic aqueous solutions using polymer inclusion membranes (PIMs). PIMs consisted of cellulose triacetate (CTA) as a support; o-nitrophenyl pentyl ether (o-NPPE) as a plasticizer; and 1-octylimidazole (1), 1-octyl-2-methylimidazole (2), 1-octyl-4-methylimidazole (3), or 1-octyl-2,4-dimethylimidazole (4) as ion carriers. The membranes were characterized by means of at. force microscopy (AFM) and SEM (SEM). The results show that Zn(II) and Cd(II) are effectively transported across PIMs, while Ni(II) transport is not effective. The rate of transport of metal ions across PIMs is determined by the diffusion rate of the M(II)-carrier complex across the membrane. The best result achieved for Zn(II) removal after 24 h was 95.5% for the ternary Zn(II)-Cd(II)-Ni(II) solution for PIM doped (4). For this membrane, the separation coefficients for Zn(II)/Cd(II), Zn(II)/Ni(II), and Cd(II)/Ni(II) were 2.8, 104.5, and 23.5, resp. Addnl., the influence of basicity and structure of carrier mols. on transport kinetics was discussed. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and Bioavailability of Novel Mucoadhesive Buccal Films for Candesartan Cilexetil in Rats was written by Mady, Omar Y.;Abulmeaty, Mahmoud M. A.;Donia, Ahmed A.;Al-Khureif, Abdulaziz A.;Al-Shoubki, Adam A.;Abudawood, Manal;Abdel Moety, Doaa A.. And the article was included in Membranes (Basel, Switzerland) in 2021.Reference of 145040-37-5 This article mentions the following:

Candesartan cilexetil (CC) is an antihypertensive drug. It has low solubility and faces hepatic first-pass metabolism after oral ingestion. We formulated bioadhesive buccal films and studied the resp. drug pharmacokinetics. Different bioadhesive films were prepared (40, 80, 120, 160, 200, and 240 mg CC per film) by using the solvent casting method. The drug concentrations used affect the drug entrapment mechanism, which was reflected in the film physicochem. properties like thickness, weight, drug content, bioadhesion, and drug release. Low drug concentration (F2, 40 mg per film) led to minute drug crystal dispersion while increasing the drug concentration (F7, 240 mg per film) showed drug crystal encapsulation, which affects the drug release. The drug pharmacokinetic from the prepared films was studied compared to the oral form by serial blood sampling via an inserted catheter in the carotid of rats. High-Performance Liquid Chromatog. assay was used to measure the plasma concentration of CC in different forms. Compared to other films, the F2 showed the highest maximal concentration (C_max) and the lowest elimination half-life (_1/2). Bioadhesion buccal film of CC has better bioavailability, especially at low concentrations The ease, robustness, and ruggedness of the preparation suggests the same procedure for drugs like CC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem