Month: January 2023

Imidazolium based ionic liquids as solvents for cellulose chemistry was written by Vitz, Juergen;Erdmenger, Tina;Schubert, Ulrich S.. And the article was included in ACS Symposium Series in 2010.HPLC of Formula: 79917-89-8 This article mentions the following:

In recent years, ionic liquids developed to advantageous solvents for the dissolution and homogeneous processing of cellulose. Even if ionic liquids were already known for their capability of efficiently dissolving cellulose for a long time, significant efforts were made in the last years. New candidates were found, but it could be shown, that some ionic liquids are involved in side reactions, too. With the aim for gaining a better insight on the dissolution properties, we screened a wide range of potentially suitable ionic liquids Remarkable results were obtained, for example an odd-even effect was found for different alkyl side chain lengths, both linear and branched, for the imidazolium based ionic liquids with chloride counterions. Furthermore, 1-ethyl-3-methylimidazolium di-Et phosphate showed promising properties for the dissolution of cellulose, e.g. a lower degradation of cellulose than for other ILs, a low m.p., and a low viscosity of the cellulose solution, simplifying the handling. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Versatile Approach to Ullmann C-N Couplings at Room Temperature: New Families of Nucleophiles and Electrophiles for Photoinduced, Copper-Catalyzed Processes was written by Ziegler, Daniel T.;Choi, Junwon;Munoz-Molina, Jose Maria;Bissember, Alex C.;Peters, Jonas C.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2013.Formula: C8H8N2 This article mentions the following:

The use of light to facilitate copper-catalyzed cross-couplings of nitrogen nucleophiles can enable C-N bond formation to occur under unusually mild conditions. In this study, we substantially expand the scope of such processes, establishing that this approach is not limited to reactions of carbazoles with iodobenzene and alkyl halides. Specifically, we demonstrate for the first time that other nitrogen nucleophiles (e.g., common pharmacophores such as indoles, benzimidazoles, and imidazoles) as well as other electrophiles (e.g., hindered/deactivated/heterocyclic aryl iodides, an aryl bromide, an activated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitable partners. Photoinduced C-N bond formation can be achieved at room temperature using a common procedure with an inexpensive catalyst (CuI) that does not require a ligand coadditive and is tolerant of moisture and a variety of functional groups. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide was written by Ivan, Beatrice-Cristina;Dumitrascu, Florea;Anghel, Adriana Iuliana;Ancuceanu, Robert Viorel;Shova, Sergiu;Dumitrescu, Denisa;Draghici, Constantin;Olaru, Octavian Tudorel;Nitulescu, George Mihai;Dinu, Mihaela;Barbuceanu, Stefania-Felicia. And the article was included in Molecules in 2021.Category: imidazoles-derivatives This article mentions the following:

A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R¹ = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR¹ having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lithium chloride-imidazolium chloride melts for the coupling reactions of propylene oxide and CO₂ was written by Nguyen, Ly Vinh;Lee, Bora;Nguyen, Dinh Quan;Kang, Min-Jung;Lee, Hyunjoo;Ryu, Seol;Kim, Hoon Sik;Lee, Je Seung. And the article was included in Bulletin of the Korean Chemical Society in 2008.Formula: C7H13ClN2 This article mentions the following:

A series of lithium chloride-imidazolium chloride (LiCl-[imidazolium]Cl) melts were prepared and their catalytic activities were evaluated for the coupling reactions of propylene oxide and CO₂. At the constant mole of LiCl, the catalytic activities of LiCl-[imidazolium]Cl melts increased with increasing molar ratio of [imidazolium]Cl/LiCl up to 2, but thereafter decreased rapidly. The variation of alkyl groups on the imidazolium ring showed a negligible effect on the catalytic activity, but the number of alkyl groups present on the imidazolium cation exerts a pronounced effect. Catalysis and electrospray ionization tandem mass spectral anal. results of LiCl-[imidazolium]Cl melts imply that the activity of the melt is strongly related to the amount of LiCl₂^– generated from the melt. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Formula: C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tris-imidazolium and benzimidazolium ionic liquids: a new class of biodegradable surfactants was written by Al-Mohammed, Nassir N.;Duali Hussen, Rusnah Syahila;Alias, Yatimah;Abdullah, Zanariah. And the article was included in RSC Advances in 2015.Name: 1-Octyl-1H-imidazole This article mentions the following:

Based on imidazolium and benzimidazolium, two series of novel tris-cationic ionic liquid surfactants containing ester groups were synthesized simply from readily available starting materials in high yields. Biodegradability and surfactants properties of the tris-imidazolium and tris-benzimidazolium ionic liquids were investigated. Some compounds showed assembly behavior in the pure form (i.e. absence of solvent) and in the presence of polar or nonpolar solvents. These surfactants are effectively reducing the surface tension of water in the range of 28-31 mN m^-1. Through using the ‘Closed-Bottle Test’ OECD 301D, the incorporation of alkyl or Ph side chains with ester groups in the same mol. significantly improved the biodegradation compared to sodium n-dodecyl sulfate (SDS) as a reference The aliphatic alkyl side chain, i.e., Bu, hexyl, octyl, decyl and dodecyl, in both imidazolium and benzimidazolium ionic liquids had marked increasing biodegradation and phase behavior results compared to aromatic side-chains. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Name: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of transition metal complexes with heteroazomethinic ligands: a comparison of traditional and electrochemical methods was written by Kharisov, B. I.;Blanco, L. M.;Garnovskii, A. D.;Burlov, A. S.;Kuznetsova, L. I.;Korovina, L. V.;Garnovskii, D. A.;Dieck, T.. And the article was included in Polyhedron in 1997.Product Details of 3012-80-4 This article mentions the following:

Transition metal complexes (M = Cu, Ni, Co, Pd, Zn and Cd) containing azomethinic ligands were synthesized by conventional chem. methods and by direct electrochem. dissolution of the sacrificial metal anode. The resulting complexes were characterized by elemental anal., IR and EPR-spectra and magnetochem. data. The influence of the type of metal, the peculiarities of the ligand structure and the methods of synthesis of metal chelates on their physicochem. properties and structure were examined In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Product Details of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Palladium-Catalyzed Tandem Ester Dance/Decarbonylative Coupling Reactions was written by Kubo, Masayuki;Inayama, Naomi;Ota, Eisuke;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2022.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

“Dance reaction” on the aromatic ring is a powerful method in organic chem. to translocate functional groups on arene scaffolds. Notably, dance reactions of halides and pseudohalides offer a unique platform for the divergent synthesis of substituted (hetero)aromatic compounds when combined with transition-metal-catalyzed coupling reactions. Herein, a tandem reaction of ester dance and decarbonylative coupling enabled by palladium catalysis is reported. In this reaction, 1,2-translocation of the ester moiety on the aromatic ring is followed by decarbonylative coupling with nucleophiles to enable the installation of a variety of nucleophiles at the position adjacent to the ester in the starting material. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroimidazoles. Part III. Ionization constants and tautomerism of imidazoles. A reinvestigation was written by Suwinski, Jerzy;Salwinska, Ewa. And the article was included in Polish Journal of Chemistry in 1981.Formula: C4H5N3O This article mentions the following:

Basic and acidic ionization constants of some simple imidazole derivatives were determined spectrophotometrically as well as potentiometrically or taken from the literature. Tautomeric equilibrium constants of the compounds containing an imino H atom were also calculated Methods and results were discussed with regard to the former literature data. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Effects of Angiotensin II or Angiotensin 1-7 on Rat Pial Microcirculation during Hypoperfusion and Reperfusion Injury: Role of Redox Stress was written by Lapi, Dominga;Cammalleri, Maurizio;Dal Monte, Massimo;Di Maro, Martina;Santillo, Mariarosaria;Belfiore, Anna;Nasti, Gilda;Damiano, Simona;Trio, Rossella;Chiurazzi, Martina;De Conno, Barbara;Serao, Nicola;Mondola, Paolo;Colantuoni, Antonio;Guida, Bruna. And the article was included in Biomolecules in 2021.Related Products of 145040-37-5 This article mentions the following:

Renin-angiotensin systems produce angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7), which are able to induce opposite effects on circulation. This study in vivo assessed the effects induced by Ang II or Ang 1-7 on rat pial microcirculation during hypoperfusion-reperfusion, clarifying the mechanisms causing the imbalance between Ang II and Ang 1-7. The fluorescence microscopy was used to quantify the microvascular parameters. Hypoperfusion and reperfusion caused vasoconstriction, disruption of blood-brain barrier, reduction of capillary perfusion and an increase in reactive oxygen species production Rats treated with Ang II showed exacerbated microvascular damage with stronger vasoconstriction compared to hypoperfused rats, a further increase in leakage, higher decrease in capillary perfusion and marker oxidative stress. Candesartan cilexetil (specific Ang II type 1 receptor (AT1R) antagonist) administration prior to Ang II prevented the effects induced by Ang II, blunting the hypoperfusion-reperfusion injury. Ang 1-7 or ACE2 activator administration, preserved the pial microcirculation from hypoperfusion-reperfusion damage. These effects of Ang 1-7 were blunted by a Mas (Mas oncogene-encoded protein) receptor antagonist, while Ang II type 2 receptor antagonists did not affect Ang 1-7-induced changes. In conclusion, Ang II and Ang 1-7 triggered different mechanisms through AT1R or MAS receptors able to affect cerebral microvascular injury. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Related Products of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study on synthesis and characterization of series functionalized ionic liquids and their physicochemical properties was written by Zhu, Li-ye;Chen, Li-gong;Wang, Ming-qi;Li, Xian-jie;Cao, Shu-han. And the article was included in Gongneng Cailiao in 2011.COA of Formula: C11H20N2 This article mentions the following:

Series functionalized ionic liquids containing ester-group I(n= 1, R = Me, X^– = BF₄^–, Tf₂N^–; n = 1, R = Bu, C₈H₁₇, X^– = Tf₂N^–; n = 2, R = Me, X^– = Tf₂N^–) were synthesized through a typical two-step way and the products were characterized by ¹H-NMR, FT-IR and elemental anal. The basic physicochem. properties and thermal stabilities of the functionalized ionic liquids were studied thoroughly and compared with a traditional nonfunctionalized ionic liquid, 3-methy-1-butylimidazolium terafluoroborate, which had the same alkyl as the functionalized ones. The ester-group functionalized ionic liquids synthesized in this paper have provided new materials and laid a foundation for further study on ionic liquids In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem