Month: January 2023

peri-Substituted imidazo[1,2-a]pyridines. A new reductive elimination reaction was written by Rees, Charles W.;Smith, David I.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Safety of 5-Bromoimidazo[1,2-a]pyridine This article mentions the following:

A new reductive elimination reaction of 3,5-disubstituted imidazo[1,2-a]pyridines I (R, R¹ = Br, NO₂) with N₂H₄ in hot EtOH is reported. A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene into 1,3-dichloro-4,6-dinitrobenzene. A variety of other 3-nitro-5-substituted imidazo[1,2-a]pyridines I (R = NO₂, R¹ = CO₂Me, CONHNH₂, CON₃, NH₂, NHCO₂Me, N₃, etc.) are described, but these could not be cyclized. The 3-amino-5-methoxycarbonyl derivative I (R = NH₂, R¹ = CO₂Me) cyclizes to the imidazoindazole II with NaOMe. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Safety of 5-Bromoimidazo[1,2-a]pyridine).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 5-Bromoimidazo[1,2-a]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bronsted acidic ionic liquids for cellulose hydrolysis in an aqueous medium: structural effects on acidity and glucose yield was written by Suzuki, Shiori;Takeoka, Yuko;Rikukawa, Masahiro;Yoshizawa-Fujita, Masahiro. And the article was included in RSC Advances in 2018.Product Details of 35487-17-3 This article mentions the following:

The conversion of cellulose into valuable chems. has attracted much attention, due to the concern about depletion of fossil fuels. The hydrolysis of cellulose is a key step in this conversion, for which Bronsted acidic ionic liquids (BAILs) have been considered promising acid catalysts. In this study, using BAILs with various structures, their acidic catalytic activity for cellulose hydrolysis assisted by microwave irradiation was assessed using the Hammett acidity function (H₀) and theor. calculations The glucose yields exceeded 10% when the H₀ values of the BAIL aqueous solutions were below 1.5. The highest glucose yield was about 36% in 1-(1-octyl-3-imidazolio)propane-3-sulfonate (Oimps)/sulfuric acid (H₂SO₄) aqueous solution A long alkyl side chain on the imidazolium cation, which increased the hydrophobicity of the BAILs, enhanced the glucose yield. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Product Details of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic pyrolysis of liquorice (Glycyrrhiza glabra L.) in a fixed-bed reactor: Effects of pyrolysis parameters on product yields and character was written by Aysu, Tevfik;Durak, Halil. And the article was included in Journal of Analytical and Applied Pyrolysis in 2015.COA of Formula: C4H5N3O This article mentions the following:

Pyrolysis of liquorice (Glycyrrhiza glabra L.) stalks were performed in a fixed-bed tubular reactor with (ZnO, FeCl₃, K₂CO₃, Al₂O₃, Na₂B₄O₇·10H₂O) and without catalyst at three different temperatures (350, 450, 550 °C) with a constant heating rate of 40 °C/min. The amounts of bio-char, bio-oil and gas produced, as well as the compositions of the resulting bio-oils were determined by GC-MS. The effects of pyrolysis parameters on product yields were investigated. The results indicate that both temperature and catalysts effect the conversions of G. glabra L. into solid, liquid and gaseous products. The highest conversion of 74.50% and liquid yield of 34.35% were obtained with Na₂B₄O₇·10H₂O catalyst at 550 °C temperature when 0.224 > Dp > 0.150 mm particle sized samples and 100 mL/min of sweeping gas flow rate were used. Liquid products (bio-oils) obtained at 350 and 550 °C were analyzed by elemental anal. and gas chromatog./mass spectrometry (GC-MS). 133 and 148 different compounds were identified by GC-MS in the bio-oils obtained at 350 and 550 °C, resp. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6COA of Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Antibacterial Activity of Imidazolium-Based Ionic Liquids Investigated by QSAR Modeling and Experimental Studies was written by Hodyna, Diana;Kovalishyn, Vasyl;Rogalsky, Sergiy;Blagodatnyi, Volodymyr;Petko, Kirill;Metelytsia, Larisa. And the article was included in Chemical Biology & Drug Design in 2016.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Predictive QSAR models for the inhibitors of B. subtilis and Ps. aeruginosa among imidazolium-based ionic liquids were developed using literary data. The regression QSAR models were created through Artificial Neural Network and k-nearest neighbor procedures. The classification QSAR models were constructed using WEKA-RF (random forest) method. The predictive ability of the models was tested by fivefold cross-validation; giving q² = 0.77-0.92 for regression models and accuracy 83-88% for classification models. Twenty synthesized samples of 1,3-dialkylimidazolium ionic liquids with predictive value of activity level of antimicrobial potential were evaluated. For all asym. 1,3-dialkylimidazolium ionic liquids, only compounds containing at least one radical with alkyl chain length of 12 carbon atoms showed high antibacterial activity. However, the activity of sym. 1,3-dialkylimidazolium salts was found to have opposite relationship with the length of aliphatic radical being maximum for compounds based on 1,3-dioctylimidazolium cation. The obtained exptl. results suggested that the application of classification QSAR models is more accurate for the prediction of activity of new imidazolium-based ILs as potential antibacterials. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Double head-to-tail direct arylation as a viable strategy towards the synthesis of the aza-analog of dihydrocyclopenta[hi]aceanthrylene – an intriguing antiaromatic heterocycle was written by Firmansyah, Dikhi;Deperasinska, Irena;Vakuliuk, Olena;Banasiewicz, Marzena;Tasior, Mariusz;Makarewicz, Artur;Cyranski, Michal K.;Kozankiewicz, Boleslaw;Gryko, Daniel T.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Computed Properties of C7H5BrN2 This article mentions the following:

The first case of double head-to-tail direct arylation of aromatic compounds and the unusual photophys. properties of the resulting 2,2a^1,5b^1,7-tetraazacyclopenta[hi]aceanthrylene are reported. This mol., comprising of two imidazo[1,2-a]pyridine units, is antiarom. due to the changes in the efficiency of π-electron ring current and it belongs to a class of seldom encountered compounds with a dark lowest electronically excited singlet state. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Computed Properties of C7H5BrN2).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C7H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The effects of cationic type ionic liquids on methane hydrate formation was written by Lu, Cui-ying. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2014.Electric Literature of C4H7ClN2 This article mentions the following:

The article has studied the effects of ionic liquids on the induction time of methane hydrate formation under different mass concentrations, temperatures and pressures. The results show: all the tested ionic liquids can postpone the induction time of hydrate forming. Among them, imimidazolium-based ones have the strongest ability; The concentrations of ionic liquids also have strong effects on the induction time, and 0.5% is optimal. In addition the inhibiting abilities of ionic liquid on the induction time change with different pressures and temperatures, but not obviously. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and antiaggregant and anticoagulant activity of new 1-(4-alkyloxybenzyl)-1H-azoles and 1-(adamantyl-1)-2-[4-(1H-azol-1-ylmethyl)-phenoxy]ethanones was written by Gurevich, K. G.;Urakov, A. L.;Basantsev, A. V.;Abzalilov, T. A.;Bashirov, I. I.;Danilin, A. A.;Purygin, P. P.;Golovanov, A. A.;Khayrzamanova, K. A.;Samorodov, A. V.. And the article was included in Pharmaceutical Chemistry Journal in 2021.Category: imidazoles-derivatives This article mentions the following:

The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols I [R = n-octyl, n-hexadecyl, 1-adamantyl; Az = imidazol-1-ylmethyl, 1,2,4-triazol-1-ylmethyl, benzimidazol-1-ylmethyl, benzotriazol-1-ylmethyl] enabled the expansion of organic synthesis methodol., which is extremely important for designing new structures with various types of biol. activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental anal. and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic Liquid-Liquid Separations Using Countercurrent Chromatography: A New General-Purpose Separation Methodology was written by Brown, Leslie;Earle, Martyn J.;Gilea, Manuela A.;Plechkova, Natalia V.;Seddon, Kenneth R.. And the article was included in Australian Journal of Chemistry in 2017.HPLC of Formula: 404001-48-5 This article mentions the following:

Liquid-liquid separations based on countercurrent chromatog., in which at least one phase contains an ionic liquid, represent a new empirical approach for the separation of organic, inorganic, or bio-based materials. A custom-designed instrument was developed and constructed specifically to perform separations (including transition metal salts, arenes, alkenes, alkanes, and sugars) with ionic liquids, and was demonstrated for use on the 0.1 to 10 g scale. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reactive-Atom Scattering from Liquid Crystals at the Liquid-Vacuum Interface: [C₁₂mim][BF₄] and 4-Cyano-4′-Octylbiphenyl (8CB) was written by Purcell, Simon M.;Tesa-Serrate, Maria A.;Marshall, Brooks C.;Bruce, Duncan W.;D’Andrea, Lucia;Costen, Matthew L.;Slattery, John M.;Smoll, Eric J.;Minton, Timothy K.;McKendrick, Kenneth G.. And the article was included in Langmuir in 2016.HPLC of Formula: 404001-48-5 This article mentions the following:

Two complementary approaches were used to study the liquid-vacuum interface of the liquid-crystalline ionic liquid 1-dodecyl-3-methylimidazolium tetrafluoroborate ([C₁₂mim][BF₄]) in the smectic A (SmA) and isotropic phases. O atoms with two distinct incident translational energies were scattered from the surface of [C₁₂mim][BF₄]. Angle-dependent time-of-flight distributions and OH yields, resp., were recorded from high- and low-energy O atoms. There were no significant changes in the measurements using either approach, nor the properties derived from them, accompanying the transition from the SmA to the isotropic phase. This indicates that the surface structure of [C₁₂mim][BF₄] remains essentially unchanged across the phase boundary, implying that the bulk order and surface structure are not strongly correlated for this material. This effect is ascribed to the strong propensity for the outer surfaces of ionic liquids to be dominated by alkyl chains, over an underlying layer rich in anions and cation head groups, whether or not the bulk material is a liquid crystal. In a comparative study, the OH yield from the surface of the liquid crystal, 8CB, was found to be affected by the bulk order, showing a surprising step increase at the SmA-nematic transition temperature, whose origin is the subject of speculation. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5HPLC of Formula: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-Catalysed Deuterium Labelling of Anilines and Electron-Rich (Hetero)Arenes was written by Bourriquen, Florian;Rockstroh, Nils;Bartling, Stephan;Junge, Kathrin;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C8H8N2 This article mentions the following:

Here, a new class of heterogeneous catalysts was reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesized and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst was fully characterized and successfully applied to the labeling of natural products as well as marketed drugs. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem