Month: January 2023

Development of a Regioselective N-Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer was written by Van Den Berge, Emilie;Robiette, Raphael. And the article was included in Journal of Organic Chemistry in 2013.Computed Properties of C8H8N2 This article mentions the following:

An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodol. involves very mild reaction conditions and tolerates a wide range of functional groups. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Computed Properties of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancement of the solubility and the dissolution rate of candesartan cilexetil using microsponge technology was written by Nazar, Shaimaa;Alhammid, Abd. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Application of 145040-37-5 This article mentions the following:

The aim of the present study is to enhance the dissolution rate of candesartan cilexetil (CC) using microsponges. Candesartan is therapeutically a potent antihypertensive agent, but it suffers a major drawback of poor oral bioavailability, which is estimated to be 15% due to its low solubility in the gastrointestinal fluids and hepatic first-pass metabolism Eudragit-based microsponges were prepared by quasi-emulsion solvent diffusion method using different drug-polymer ratios (1:1 to 1:6), stirring speeds (250-750 rpm), and emulsifier concentrations (polyvinyl alc.) (0.05%-0.083% w/v). Differential scanning calorimetry (DSC) and Fourier transform IR spectroscopy (FTIR) study for CC, phys. mixtures of drug-polymer, and selected formula were investigated to estimate compatibility of CC with other used ingredients. All formulations were evaluated for particle size, production yield, and loading efficiency. The in vitro drug release study of optimized formulation was performed in phosphate buffer pH 6.8. The obtained results indicated that formula F3 which contains eudragit RS100 at drug:polymer ratio (6:1) was showed the smallest particle size with higher production yield and loading efficiency. DSC and FTIR study of the phys. mixtures of drug and polymer revealed no drug-polymer interaction. The results clearly confirm that the percentage of CC released at 30 min from F3, CC powder, and self-made tablet was 54%, 20.325, and 38.9%, resp. Microsponges technique was considered as a promising system to enhance the solubility and dissolution rate of poor-water soluble CC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites was written by Oba, Yasuhiro;Takano, Yoshinori;Furukawa, Yoshihiro;Koga, Toshiki;Glavin, Daniel P.;Dworkin, Jason P.;Naraoka, Hiroshi. And the article was included in Nature Communications in 2022.SDS of cas: 26832-08-6 This article mentions the following:

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Investigations on benzimidazole-absorption spectra and chromiferous properties was written by Mangini, Angelo;Montanari, Fernando;Passerini, Riccardo. And the article was included in Atti accad. nazl. Lincei, Rend. Classe sci. fis., mat. e. nat. in 1952.HPLC of Formula: 4887-83-6 This article mentions the following:

The results are tabulated of absorption-spectrum measurements of derivatives of benzimidazole substituted in either the 4 or 5 position by H, CH₃, Cl, Br, OCH₃, NH₂, or NO₂, and 2-phenylbenzimidazole substituted with various possible combinations of the above substituents in the 4 or 5 positions and in the o, m, or p positions in the phenyl group. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and use of 2-alkylbenzimidazoles was written by Xie, Chuan;Wan, Shen-dian;Liu, Yu-shu. And the article was included in Sichuan Lianhe Daxue Xuebao, Gongcheng Kexueban in 1999.Related Products of 13060-24-7 This article mentions the following:

Title compounds I (R = CH₃(CH₂)₄, CH₃(CH₂)₅, CH₃(CH₂)₆, CH₃(CH₂)₇, CH₃(CH₂)₈) were prepared from o-phenylenediamine and fatty acids RCOOH (R as above). The paper tested the phys. property of the compounds and characterized their structures. The result of the tests showed that the preflux could prevent oxidation of copper and had excellent solderability. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Related Products of 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cu-Al composite as the negative electrode for long-life Al-ion batteries was written by Jiao, Handong;Jiao, Shuqiang;Song, Wei-Li;Chen, Haosen;Wang, Mingyong;Tu, Jiguo;Fang, Daining. And the article was included in Journal of the Electrochemical Society in 2019.COA of Formula: C4H7ClN2 This article mentions the following:

Rechargeable Al-ion batteries have attracted great interest due to their advantages in high anode capacity, high safety, etc. However, conventional Al foil neg. electrode has critical problems in corrosion and pulverization. Here, we propose a novel Cu-Al composite, which is prepared by a facile electrochem. plating approach, as the neg. electrode for addressing above challenges. Remarkably, the plated Cu foil neg. electrode delivers excellent stability and long cycle life compared with the Al foil neg. electrode, although its thickness and areal mass d. are only 30% and �6% of that of the Al foil neg. electrode, resp. The essential pulverization problem in bare Al neg. electrode would be dramatically reduced attributing to excellent corrosion resistance of Cu foil. Besides, the plated Al is still attached to the Cu foil during repeated charge-discharge processes, resulting in a nearly 100% Coulombic efficiency even after long-term cycling. More importantly, the plated Cu foil neg. electrode is convenient for the large-scale practical applications. In view of our results, this work opens an effective approach for configuring low-cost, high energy d., long cycle life and scalable neg. electrode of Al-ion batteries. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3COA of Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Characterization of the chemical differences between solvent extracts from Pu-erh tea and Dian Hong black tea by CP-Py-GC/MS was written by Gong, Jia-shun;Tang, Chao;Peng, Chun-xiu. And the article was included in Journal of Analytical and Applied Pyrolysis in 2012.HPLC of Formula: 26832-08-6 This article mentions the following:

Solvent extracts from a type of Pu-erh tea and Dian Hong black tea were characterized by Curie-point pyrolysis-gas chromatog.-mass spectroscopy (CP-Py-GC/MS). The ethyl-acetate extracts from both teas showed similar CP-Py-GC/MS results, with main pyrolytic products of carbon dioxide, caffeine, o-phenols, and phthalate esters. During pyrolysis, the n-butanol extract from Pu-erh tea formed carbon dioxide (38.92% of total pyrolytic products), alkaloids (49.7%), and nitrogen oxides (8.38%), as well as a small fraction of esters. The n-butanol extract from Dian Hong tea formed mainly alcs., amines, esters, phenols, carboxylic acids, and alkaloids. The raw theabrownin extracts (ethanol precipitates) from the two teas produced substantially different CP-Py-GC/MS results. The raw theabrownin extract from Pu-erh tea formed mostly carbon dioxide during pyrolysis, whereas the counterpart extract from Dian Hong tea formed mainly carbon dioxide (48.23%) and nitrogen oxides (35.39%). The 3.5-100 kDa fractions separated from the theabrownin extracts of the two teas showed similar CP-Py-GC/MS results, whereas the fractions <3.5 kDa and >100 kDa formed substantially different pyrolytic products. These results showed that solvent extracts from Pu-erh tea and Dian Hong tea had substantially different chem. compositions and structures. The study suggested that CP-Py-GC/MS can be used to effectively identify chem. differences between tea extracts In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6HPLC of Formula: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of ionic liquids on the conformation of a porphyrin-based viscometer was written by Jameson, Laramie P.;Kimball, Joseph D.;Gryczynski, Zygmunt;Balaz, Milan;Dzyuba, Sergei V.. And the article was included in RSC Advances in 2013.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Structure of the cationic and anionic counterparts of ionic liquids has a significant impact on the conformational bias of the porphyrin rotor; an apparent correlation between the conformation and the viscosity of ionic liquids was noted, albeit it was found to be distinct and more complex from that found in mol. solvents. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics was written by Chen, Chao;Xu, Chang;Li, Tongyu;Lu, Siming;Luo, Fangzhou;Wang, Hangxiang. And the article was included in European Journal of Medicinal Chemistry in 2020.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

There is an urgent need for more effective, less toxic cancer therapy agents. Motivated by this need, we synthesized a small panel of N-heterocyclic carbene (NHC)-coordinated ruthenium(II) arene complexes Ru1–Ru6 with the formula [Ru(p-cymene)(L)Cl]PF₆ (L = NHC ligand with varying substituents). Cell-based in vitro studies revealed that despite the structural similarity, Ru1–Ru6 exhibited distinct cytotoxic activities against cancer cells. In particular, Ru4 and Ru6, which bear n-octyl and pentamethylbenzyl motifs, resp., were the most active at inducing apoptosis. In human ovarian A2780 cancer cells, Ru4 and Ru6 showed the highest cytotoxicities with IC₅₀ values of 2.74 ± 0.15μM and 1.98 ± 0.10μM, resp., and they were approx. 2-fold more potent than cisplatin (IC₅₀ = 5.55 ± 0.37μM). In addition to the cell killing capacity, inhibition of cell migration was validated by using these two optimized complexes. Mechanistic studies revealed that Ru4 and Ru6 complexes induced apoptosis in a caspase-dependent manner, primarily through intracellular reactive oxygen species (ROS) overproduction and cell cycle arrest at G1 phase. Furthermore, in a preclin. metastatic model of A2780 tumor xenograft, administration of Ru4 and Ru6 (20μmol/kg) resulted in a marked inhibition of tumor progression and metastasis. Finally, a substantially alleviated systemic toxicity was observed for both complexes in comparison with cisplatin in animals. Overall, this study greatly increases our understanding of NHC-coordinated Ru(II) arene metallodrugs, aiding further investigation of their therapeutic potential in the treatment of metastatic cancers. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and cytotoxicity evaluation of novel C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates was written by Kumar, Rohtash;Lown, J. William. And the article was included in Organic & Biomolecular Chemistry in 2003.HPLC of Formula: 169770-25-6 This article mentions the following:

The C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamides, e.g. I (n = 1 – 3; X = N, CH; R = Me₃CO₂C), were synthesized and their preliminary anticancer evaluation was carried out against three types of cancer cells. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6HPLC of Formula: 169770-25-6).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 169770-25-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem