Month: January 2023

KOtBu-Catalyzed 1,2-Silaboration of N-Heteroarenes to Access 2-Silylheterocycles: A Cooperative Model for the Regioselectivity was written by Jeong, Eunchan;Heo, Joon;Jin, Seongho;Kim, Dongwook;Chang, Sukbok. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 1632-83-3 This article mentions the following:

Reductive functionalization of N-heteroarenes offers a route to highly versatile heterocyclic synthons bearing multiple transformable groups. The authors present herein the development of KOtBu-catalyzed 1,2-silaboration of a broad range of N-heteroarenes, affording heterocyclic allylamines or enamines with the formation of a sp³ C2-Si bond. These labile compounds were isolated either as their N-acyl derivatives or as rearomatized 2-silyl-N-heteroarenes by the 1-pot procedures. A model of the six-membered ion-pair complex is proposed to rationalize the observed 1,2-regioselectivity, wherein KOtBu catalyst plays an associative role in activating the substrate and silylborane reagent. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrothermal syntheses, structures, and properties of the first examples of lanthanide 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate complexes was written by Wen, Hui-Liang;Wen, Wen;Li, Dan-Dan;Liu, Chong-Bo;He, Min. And the article was included in Journal of Coordination Chemistry in 2013.Formula: C22H16N2O2 This article mentions the following:

Three new lanthanide coordination polymers with 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoic acid (H₂PA), [Ln(HPA)₃(H₂O)₂]·2H₂O [Ln = Pr (1); Eu (2); Er (3)] were obtained by hydrothermal syntheses and characterized by single crystal x-ray diffraction, elemental anal., IR spectroscopy, and powder X-ray diffraction. Complexes 1–3 are isomorphous 2-dimensional supramol. structures, in which lanthanide ions are bridged by carboxyl groups of HPA^– to form 1-dimensional chain structures, and the chains are further linked to 2-dimensional supramol. structures by hydrogen bonds. HPA^– exhibit chelating and μ₂-bridging coordination mode. The TGA of was carried out to examine the thermal stability and the photoluminescence of was investigated. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Formula: C22H16N2O2).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C22H16N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nonchromatographic Speciation of Selenium in Edible Oils Using Dispersive Liquid-Liquid Microextraction and Electrothermal Atomic Absorption Spectrometry was written by Lopez-Garcia, Ignacio;Vicente-Martinez, Yesica;Hernandez-Cordoba, Manuel. And the article was included in Journal of Agricultural and Food Chemistry in 2013.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

A methodol. for the nonchromatog. separation of the main selenium species present in edible oils is presented. Dispersive liquid-liquid microextraction is used to extract inorganic selenium (iSe), seleno-L-cystine (SeCys₂), seleno-L-methionine (SeMet), and selenocystamine (SeCM) into a slightly acidic aqueous medium. The selenium total (tSe) content is measured in the extracts by electrothermal at. absorption spectrometry. By repeating the microextraction stage using an ionic liquid instead of water, the sum of SeCys₂, SeMet, and SeCM is obtained and iSe is calculated by difference. The detection limit is 0.03 ng of Se per g of oil. The fractionation of the edible oils by solid phase extraction followed by dispersive liquid-liquid extraction and at. absorption measurement also permits speciation of iSe to be carried out. Data for tSe and iSe levels of 15 samples of different origin are given. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): Extended Follow-Up of a 2×2 Factorial, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Candesartan and Metoprolol was written by Heck, Siri Lagethon;Mecinaj, Albulena;Ree, Anne Hansen;Hoffmann, Pavel;Schulz-Menger, Jeanette;Fagerland, Morten Wang;Gravdehaug, Berit;Rosjo, Helge;Steine, Kjetil;Geisler, Juergen;Gulati, Geeta;Omland, Torbjorn. And the article was included in Circulation in 2021.Product Details of 145040-37-5 This article mentions the following:

Adjuvant breast cancer therapy containing anthracyclines with or without anti-human epidermal growth factor receptor-2 antibodies and radiotherapy is associated with cancer treatment-related cardiac dysfunction. In the PRADA trial (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy), concomitant treatment with the angiotensin receptor blocker candesartan attenuated the reduction in left ventricular ejection fraction (LVEF) in women receiving treatment for breast cancer, whereas the β-blocker metoprolol attenuated the increase in cardiac troponins. This study aimed to assess the long-term effects of candesartan and metoprolol or their combination to prevent a reduction in cardiac function and myocardial injury. In this 2×2 factorial, randomized, placebo-controlled, double-blind, single-center trial, patients with early breast cancer were assigned to concomitant treatment with candesartan cilexetil, metoprolol succinate, or matching placebos. Target doses were 32 and 100 mg, resp. Study drugs were discontinued after adjuvant therapy. All 120 validly randomized patients were included in the intention-to-treat anal. The primary outcome measure was change in LVEF assessed by cardiovascular magnetic resonance imaging from baseline to extended follow-up. Secondary outcome measures included changes in left ventricular volumes, echocardiog. peak global longitudinal strain, and circulating cardiac troponin concentrations A small decline in LVEF but no significant between-group differences were observed from baseline to extended follow-up, at a median of 23 mo (interquartile range, 21 to 28 mo) after randomization (candesartan, 1.7% [95% CI, 0.5 to 2.8]; no candesartan, 1.8% [95% CI, 0.6 to 3.0]; metoprolol, 1.6% [95% CI, 0.4 to 2.7]; no metoprolol, 1.9% [95% CI, 0.7 to 3.0]). Candesartan treatment during adjuvant therapy was associated with a significant reduction in left ventricular end-diastolic volume compared with the noncandesartan group (P=0.021) and attenuated decline in global longitudinal strain (P=0.046) at 2 years. No between-group differences in change in cardiac troponin I and T concentrations were observed Anthracycline-containing adjuvant therapy for early breast cancer was associated with a decline in LVEF during extended follow-up. Candesartan during adjuvant therapy did not prevent reduction in LVEF at 2 years, but was associated with modest reduction in left ventricular end-diastolic volume and preserved global longitudinal strain. These results suggest that a broadly administered cardioprotective approach may not be required in most patients with early breast cancer without preexisting cardiovascular disease. URL: https://www.clinicaltrials.gov; Unique identifier: NCT01434134. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkylation of 4(5)-substituted imidazoles was written by Benjes, Paul;Grimmett, Ross. And the article was included in Heterocycles in 1994.Category: imidazoles-derivatives This article mentions the following:

4(5)-Substituted imidazoles were alkylated under “neutral” and alk. conditions to give mixtures of isomers in ratios which depended on the reaction conditions, and the nature of the substituent and alkylating agents. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Category: imidazoles-derivatives).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Substituent effects on proton affinities: through bonds or through space mechanism? was written by Catalan, Javier;Perez, Pilar;Elguero, Jose. And the article was included in Heterocycles in 1983.SDS of cas: 3034-41-1 This article mentions the following:

INDO calculations of the protonation energies and lone pair orbital energies of twenty pyrazoles and twenty imidazoles have been carried out in order to ascertain the mechanism of the substituent effect; Me, cyano, fluoro, amino, and nitro substituents have been examined The nitro group shows a special behavior. The importance of optimizing the geometry and the reasons for the anomaly shown by the nitro derivatives are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1SDS of cas: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Model reactions for enzymic catalysis. I. Nonenzymic transamination between α-amino acids and 2-formylimidazoles was written by Gebert, Ulrich;Von Kerekjarto, Bela. And the article was included in Justus Liebigs Annalen der Chemie in 1968.SDS of cas: 22600-77-7 This article mentions the following:

2-Formylimidazole and 1-benzyl-2-formylimidazole transaminated, in the presence of Ni2+, Co2+, and Cu2+, α-amino acids into α-keto acids. The pH optimum was 8.5 for the Ni2+- and Co2+-catalyzed reactions, while the Cu2+-catalyzed reactions showed no pH dependence. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7SDS of cas: 22600-77-7).

(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 22600-77-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group was written by Tang, Xiao-Jun;Wu, Yayun;Zhao, Rong;Kou, Xiaolong;Dong, Zaizai;Zhou, Wei;Zhang, Zhen;Tan, Weihong;Fang, Xiaohong. And the article was included in Angewandte Chemie, International Edition in 2020.Product Details of 25676-75-9 This article mentions the following:

The photorelease of bioactive mols. has emerged as a valuable tool in biochem. Nevertheless, many important bioactive mols., such as pyridine derivatives, cannot benefit from currently available organic photoremovable protecting groups (PPGs). The inefficient photorelease of pyridines is attributed to intramol. photoinduced electron transfer (PET) from PPGs to pyridinium ions. To alleviate PET, the authors rationally designed a strategy to drive the excited state of PPG from S₁ to T₁ with a heavy atom, and synthesized a new PPG by substitution of the H atom at the 3-position of 7-dietheylamino-coumarin-4-Me (DEACM) with Br or I. This resulted in an improved photolytic efficiency of the pyridinium ion by hundreds-fold in aqueous solution The PPG can be applied to various pyridine derivatives The successful photorelease of a microtubule inhibitor, indibulin, in living cells was demonstrated for the potential application of this strategy in biochem. research. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Product Details of 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkylation of 4(5)-substituted imidazoles was written by Benjes, Paul;Grimmett, Ross. And the article was included in Heterocycles in 1994.Product Details of 3034-41-1 This article mentions the following:

4(5)-Substituted imidazoles were alkylated under “neutral” and alk. conditions to give mixtures of isomers in ratios which depended on the reaction conditions, and the nature of the substituent and alkylating agents. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chlorodifluoromethane as a C1 Synthon in the Assembly of N-Containing Compounds was written by Ma, Xingxing;Su, Jianke;Zhang, Xingang;Song, Qiuling. And the article was included in iScience in 2019.Electric Literature of C8H8N2 This article mentions the following:

A quadruple cleavage of chlorodifluoromethane to yield a C1 source, which was successfully employed in the construction of various N-containing compounds e.g., C₆H₅N(CH₃)CH=NC₆H₅ especially with pharmaceutical mols. under mild conditions was reported. This strategy provides a useful method for late-stage modification of pharmaceutical compounds Four bonds in ClCF₂H were orderly cleaved under basic conditions in the absence of transition metals. Preliminary mechanistic studies revealed that (E)-N-phenylformimidoyl fluoride intermediate is involved in this process by in situ ¹H NMR studies and control experiments In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem