Month: January 2023

Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships was written by Murray, Michael;Ryan, Adrian J.;Little, Peter J.. And the article was included in Journal of Medicinal Chemistry in 1982.Synthetic Route of C8H8N2 This article mentions the following:

Eighty-two benzimidazole derivatives, some which were synthesized, were tested for the ability to inhibit cytochrome P-450 mediated enzyme activity, specifically aminopyrine N-demethylase  [9037-69-8], from phenobarbitone-induced rat hepatic microsomes. Using physicochem. parameters and multiple regression anal., a quant. structure-activity relationship (QSAR) that describes up to 87% of the data variance in terms of hydrophobic and electronic effects and the molar refractivity of the substituent in the 2-position of the benzimidazole ring is presented. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hierarchically structured polymeric ionic liquids and polyvinylpyrrolidone mat-fibers fabricated by electrospinning was written by Montolio, Silvia;Abarca, Gabriel;Porcar, Raul;Dupont, Jairton;Burguete, Maria Isabel;Garcia-Verdugo, Eduardo;Luis, Santiago V.. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2017.Formula: C11H20N2 This article mentions the following:

Different polymeric ionic liquids/polyvinylpyrrolidone (PILs/PVP) fiber membranes were prepared by electrospinning from the corresponding polymeric blends. Supramol. interpolymeric interactions between PILs and PVP seem to define not only the solution properties but also the final morphol. and performance of the mat-fibers. The fine tuning of the counter anion and the length of the alkyl chain allows modulating both their hydrophilic/hydrophobic properties and their morphol. In this way, it was possible to obtain materials with potential applications in different fields as highlighted by the promising results obtained for oil-water separation or for the synthesis and stabilization of AuNPs. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fe-BPsalan Complex-Catalyzed Asymmetric [4 + 2] Cycloaddition of Cyclopentadiene with α,β-Unsaturated Heterocycles was written by Chen, Kai-Ge;Lu, Hao;Zhou, Yi-Ming;Wan, Xiao-Long;Wang, Hao-Yang;Xu, Zhen-Jiang;Guo, Hai-Ming;Che, Chi-Ming. And the article was included in Journal of Organic Chemistry in 2022.Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

An efficient iron-catalyzed asym. [4 + 2] cycloaddition of cyclopentadiene with α,β-unsaturated acyl imidazoles or 2-cinnamoylisoindoline-1,3-dione derivatives was developed to afford the addition products in high yield and selectivity. Interestingly, the absolute structures of the addition products were controlled by the auxiliaries via different coordination modes with the same type of catalyst. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cation molecular structure affects mobility and transport of electrolytes in porous carbons was written by Osti, Naresh C.;Dyatkin, Boris;Gallegos, Alejandro;Voneshen, David;Keum, Jong K.;Littrell, Ken;Zhang, Pengfei;Dai, Sheng;Wu, Jianzhong;Gogotsi, Yury;Mamontov, Eugene. And the article was included in Journal of the Electrochemical Society in 2019.Product Details of 404001-48-5 This article mentions the following:

We examined the electrosorption and ion dynamics of imidazolium-based room temperature ionic liquids (RTILs) having short (3-carbon, C3mim+) and long (12-carbon, C12mim+) cations, i.e., 1-propyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (C3mimTFSI) and 1-dodecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (C12mimTFSI), confined in ordered mesoporous carbon (OMC) and analyzed the influence of the cation alkyl chain length on the ion dynamics and the capacitive behavior using electrochem. measurements together with quasi-elastic neutron scattering (QENS) observations and classical d. functional theory (cDFT) computations. Electrochem. tests highlighted the significant influence of specific applied potentials on accumulated charge storage densities and on the limits of saturation of larger electrolytes in the pores. Computational analyses corroborated these findings and predicted a 16% increase in the capacitance of the smaller-cation electrolyte under high applied potentials. However, QENS experiments revealed a behavior of decoupling of alkyl chain dynamics from the ring in electrolytes with larger ions. cDFT calculations identified d. spikes for C12mim+ away from the pore walls to further corroborate this unique behavior. Our insights into chain length-dependent dynamics and electrosorption in complex electrolyte-electrode systems deepen fundamental understanding of confined RTIL electrolyte behavior in the porous carbon electrodes. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Organocatalytic Enantioselective Conjugate Alkynylation of β-Aminoenones: Access to Chiral β-Alkynyl-β-Amino Carbonyl Derivatives was written by Wang, Jian-Fei;Meng, Xin;Zhang, Chao-Huan;Yu, Chuan-Ming;Mao, Bin. And the article was included in Organic Letters in 2020.Application of 1632-83-3 This article mentions the following:

Readily available potassium alkynyltrifluoroborates were used for organocatalytic asym. conjugate alkynylation of β-enaminones. The interception of a modified binaphthol catalyst and in situ generated organodifluoroboranes proved important to access functionalized β-alkynyl-β-amino carbonyls and derivatives with improved chemo-reactivity and enantio-induction. Mechanistic studies revealed the impact of mol. sieves on efficiency and stereocontrol. The products undergo addnl. functionalization to yield a diverse set of valuable β-alkynyl-β-amino carbonyl scaffolds. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Benzotriazole and related compounds as corrosion inhibitors for copper was written by Cotton, Joseph B.;Scholes, Ian R.. And the article was included in British Corrosion Journal in 1967.Reference of 4887-83-6 This article mentions the following:

With reference to the corrosion inhibition of Cu by benzotriazole and analogous compounds reacted with Cu+ and Cu2+ ions. Recent data and practical operational experience are detailed. Related compounds included those where 1 or 2 of the N atoms of benzotriazole are substituted by C or the labile H atom is replaced by a CH3 group, i.e. indazole, benzimidazole, indole, and methyl benzotriazole. Salt-spray testing showed only benzotriazole and indazole prevented staining and only the former retained tarnish-resistant properties after the treated Cu surface was washed with organic solvents; the N-H group and one another N atoms and an insoluble complex formation appear necessary. Substitutional studies in the benzene ring showed Cl or nitro-groups in the 5-position increased acidity of the labile H atom but did not affect inhibition effects; naphthotriazole behaved similarly but 5-hydroxy indazole and 4-methyl benzimidazole were less effective than the parent compounds Generally 5-membered heterocyclics, imidozole, 1,2,4-triazole, and pyrazole and their derivatives showed little inhibitive effect. The benzotriazole-CuCl2 reaction product had a metal-organic ratio of 1 atom Cu: 1 mol. of benzotriazole; it was diamagnetic, amorphous, or microcrystalline, probably with a basic formula C6H4N3Cu. Reaction with CuCl2 did not give a 2:1 benzotriazole:Cu ratio and the product had excess Cu, chloride and H2O. The surface film apparently forms a true metal surface bond and the complex is polymeric. Application aspects discussed include dipping procedure, its use for brass coiled strip protection out-of-doors, swabbing processes, the use of impregnated paper for protection, its application to maintain solderability on surfaces, its use with brass nickel, silver, etc. to stop stress corrosion, etc. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anisotropic ionic conductivity in fluorinated ionic liquid crystals suitable for optoelectronic applications was written by Abate, Antonio;Petrozza, Annamaria;Cavallo, Gabriella;Lanzani, Guglielmo;Matteucci, Francesco;Bruce, Duncan W.;Houbenov, Nikolay;Metrangolo, Pierangelo;Resnati, Giuseppe. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2013.Computed Properties of C11H20N2 This article mentions the following:

The authors report a library of thirteen fluorinated ionic liquids consisting of iodide salts of 1-alkyl-3-polyfluoroalkyl-imidazolium cations. By changing the length of the alkyl and polyfluoroalkyl pendants, particular combinations of these result in compounds showing a mesophase. The nature and the mol. arrangement of the mesophase are characterized by polarized optical microscopy and powder x-ray diffraction anal., among others. After the addition of I₂ to generate the I^–/I₃^– redox couple, anisotropic ionic conductivity takes place along preferential pathways in the lamellar structure of the mesophase. Notably, the addition of I₂ does not suppress the mesophase temperature range, contrary to previously reported systems. Also, the tendency of these materials to supercool allows the mol. arrangement in the mesophase to be retained in a solid film at ambient temperatures Finally, the authors demonstrate their applicability as a quasi-solid electrolyte by preparing dye-sensitized solar cells with power conversion efficiencies comparable to the previous reports. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction. was written by Tromp, Jasper;Shen, Li;Jhund, Pardeep S;Anand, Inder S;Carson, Peter E;Desai, Akshay S;Granger, Christopher B;Komajda, Michel;McKelvie, Robert S;Pfeffer, Marc A;Solomon, Scott D;Køber, Lars;Swedberg, Karl;Zile, Michael R;Pitt, Bertram;Lam, Carolyn S P;McMurray, John J V. And the article was included in Journal of the American College of Cardiology in 2019.Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

BACKGROUND: Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. OBJECTIVES: This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. METHODS: Using data on patients with left ventricular ejection fraction ≥45% from 3 large HFpEF trials (TOPCAT [Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function], I-PRESERVE [Irbesartan in Heart Failure With Preserved Systolic Function], and CHARM Preserved [Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity]), patients were categorized according to age: ≤55 years (n = 522), 56 to 64 years (n = 1,679), 65 to 74 years (n = 3,405), 75 to 84 years (n = 2,464), and ≥85 years (n = 398). This study compared clinical and echocardiographic characteristics, as well as mortality and hospitalization rates, mode of death, and quality of life across age categories. RESULTS: Younger patients (age ≤55 years) with HFpEF were more often obese, nonwhite men, whereas older patients with HFpEF were more often white women with a higher prevalence of atrial fibrillation, hypertension, and chronic kidney disease (eGFR <60 ml/min/1.73 m²). Despite fewer comorbidities, younger patients had worse quality of life compared with older patients (age ≥85 years). Compared with patients age ≤55 years, patients age ≥85 years had higher mortality (hazard ratio: 6.9; 95% confidence interval: 4.2 to 11.4). However, among patients who died, sudden death was, proportionally, the most common mode of death (p < 0.001) in patients age ≤55 years. In contrast, older patients (age ≥85 years) died more often from noncardiovascular causes (34% vs. 20% in patients age ≤55 years; p < 0.001). CONCLUSIONS: Compared with the elderly, younger patients with HFpEF were less likely to be white, were more frequently obese men, and died more often of cardiovascular causes, particularly sudden death. In contrast, elderly patients with HFpEF had more comorbidities and died more often from noncardiovascular causes. (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function [TOPCAT]; NCT00094302; Irbesartan in Heart Failure With Preserved Systolic Function [I-PRESERVE]; NCT00095238; Candesartan Cilexetil in Heart Failure Assessment of Reduction in Mortality and Morbidity [CHARM Preserved]; NCT00634712). In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A facile ionic liquid approach to prepare cellulose-rich aerogels directly from corn stalks was written by Li, Xiaoqian;Lu, Xingmei;Yang, Jiming;Ju, Zhaoyang;Kang, Ying;Xu, Junli;Zhang, Suojiang. And the article was included in Green Chemistry in 2019.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Aerogels derived from corn stalks are promising materials for wide use, due to their biodegradability and biocompatibility. However, preparation of cellulose-rich aerogels directly from corn stalks is a tedious and complicated process. In this study, generation of cellulose-rich aerogels was achieved by a facile approach relying on an ionic liquid and amido-sulfonic acid used as solvents. By this method, cellulose-rich aerogels were directly obtained from corn stalks through a process whereby lignin was separated from the other components of the corn stalks in one step, an approach simplifying the traditional fabrication processes. The composition, morphol. and thermal stability of the obtained aerogels were investigated as they were related to the ionic liquid solvent systems used. Furthermore, the dye adsorption mechanism of cellulose-rich aerogels was simulated. In the most favorable case, the obtained aerogel was free of lignin and had the cellulose content as high as 88.1%. In addition, the aerogel possessed a porous three-dimensional structure with a high specific area (201 m² g^-1) and good thermal stability. Owing to its excellent properties, this cellulose-rich porous aerogel is expected to have a potential use in dye adsorption and other fields. This aerogel displayed an absorption capacity of 549 mg g^-1 for Congo red and 302 mg g^-1 for Coomassie brilliant blue. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dimethyl phosphorothioate and phosphoroselenoate ionic liquids as solvent media for cellulosic materials was written by Hummel, Michael;Froschauer, Carmen;Laus, Gerhard;Roeder, Thomas;Kopacka, Holger;Hauru, Lauri K. J.;Weber, Hedda K.;Sixta, Herbert;Schottenberger, Herwig. And the article was included in Green Chemistry in 2011.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

A series of novel ionic liquids comprising two asym. phosphate-derived anions, namely di-Me phosphorothioate and di-Me phosphoroselenoate, and several imidazolium and non-imidazolium-based cations was prepared via a facile synthetic route. Thermal degradation was studied by dynamic thermogravimetric anal. (TGA) revealing a slightly higher stability of the imidazolium ionic liquids and an overall low thermal stability for the phosphoroselenoate salts. Long-term moisture sorption anal. showed correlation with the polarity of the cation and differences in absorption and desorption kinetics. Finally, a Eucalyptus globulus kraft paper grade pulp was dissolved and subsequently regenerated to assess the degradation of the various mol. weight fractions by size exclusion chromatog. In addition, pre-extracted xylan was subjected to the same dissolution procedure to examine the degradation of low-mol. weight components in more detail. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem