Month: January 2023

Nitroimidazoles was written by Cosar, Charles;Crisan, Cornel;Horclois, Raymond;Jacob, Robert M.;Robert, Jacques;Tchelitcheff, Serge;Vaupre, Roger. And the article was included in Arzneimittel-Forschung in 1966.Application of 3034-41-1 This article mentions the following:

2-Alkyl 2-(4 or 5)nitroimidazoles were synthesized. Thus, 380 g. 2-methylimidazole was dissolved in 926 ml. 10N H2SO4, to obtain 2-methylimidazole acid sulfate (red oil) which was nitrated by treating with 550 ml. HNO3 (d. 1.38) and then 160 ml. HNO3 (d. 1.49) and 640 ml. H2SO4 (d. 1.83) with cooling at 18° to give 39% 2-methyl-4(5)-nitroimidazole (I, R = Me), m. 255°. Similarly were prepared the following I (R, m.p., and % yield given): H, 306° (2.5N HCl), 64; Et, 158° (H2O), 29; iso-Pr, 180° (H2O), 31. II were prepared from I by alternate methods. Method A: 38.1 g. I (R = Me) was mixed with 25.2 g. EtOK (18% in EtOH) and 100 ml. HCONMe2, EtOH was distilled, the residue was diluted with 200 ml. HCONMe2 and 37.8 g. Me2SO4 added dropwise, and the mixture heated 3 hrs. at 100° to give 62% 1,2-dimethyl-4-nitroimidazole, m. 183° (iso-PrOH). Method B: 13 g. Et2SO4 was added dropwise to a mixture of 17 g. 4-nitroimidazole, 90 ml. 2.5N NaOH, and heated 20 min. at 45°; after cooling a new addition of 90 ml. NaOH and 13 g. Et2SO4 was made, and the mixture heated 45 min. at 45°. Extraction with CHCl3 gave 27% 5.8 g. 1-ethyl-4-nitroimidazole, m. 40°. Method C: By heating 2 hrs. at 140-5° a mixture of 12.7 g. I and 22.6 g. PhCH2Cl, there was obtained 57% 1-benzyl-2-methyl-4-nitroimidazole, m. 106°. Similarly were prepared the II in the first table. [TABLE OMITTED] 2-Methyl-5-nitroimidazole (635 g.) and 3.22 kg. HO-CH2CH2Cl was refluxed 24 hrs. to yield 41% 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, m. 160°. Similarly were prepared the III in the 2nd table. Esters of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (IV) were prepared by reaction of acid chloride and C5H5N with the IV (R = H). Thus were prepared the following IV (R, m.p., and % yield given): Ac, 74°, 60; COCHCl2 87°, 51; COCMe3, 39°, 26; palmitoyl, 55°, 68; stearoyl, 51°, 34; CO-(CH2)2CO2H, 109°, 89; neutral succinate, 129°, 39; COCH:CHPh, 100°, 44; Bz, 102°, 89; COC6H4Cl-o, 104°, 61; COC6H4-OH-o, 154°, 15; COC6H4OMe-p, 102°, 56; COC6H2(OMe)3-3,4,5, 116°, 45; COC6H4NO2-p, 166°, 22; neutral phthalate, 130°, 13. Derivatives of 2-nitroimidazole were prepared: 1-methyl-2-nitroimidazole, m. 105°, and 1-(2-hydroxyethyl)-2-nitroimidazole, m. 116°. The NO2 in position 4 or 5 was studied by ir spectroscopy. The influence of the position of the nitro group and the nature of the other substituents on the antitrichomonas activity was studied. The 5-nitro derivatives were always found to be more active than derivatives of 4-nitroimidazole. In the 5-nitroimidazole series, the best products are those carrying a Me group in the 2-position and in the 1-position; a short saturated aliphatic chain being optionally substituted, and the presence of a hydroxy group decreasing considerably the toxicity of the product. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Application of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug was written by Sharhan, Olla;Heidelberg, Thorsten;Hashim, Najihah Mohd.;Al-Madhagi, Wafa M.;Ali, Hapipah Mohd.. And the article was included in Inorganica Chimica Acta in 2020.Computed Properties of C8H8N2 This article mentions the following:

A series of N-alkylated benzimidazolium salts based on 9-substituted acridine has been synthesized and subsequently converted into the corresponding Ag(I) carbene complexes. The compounds were characterized by IR, ¹H and ¹³C NMR spectroscopy. Identity and purity were confirmed by HRMS and elemental anal., resp. Both, ligands and complexes, were evaluated on their antibacterial and anticancer potential. All complexes exhibited higher activity against both Gram pos. and Gram neg. bacterial strains than the corresponding ligands. Human cell line experiments indicated low in-vitro cytotoxicity, while some of the complexes showed promising activity against breast cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Irreversible Humidity-Responsive Phosphorescence Materials from Cellulose for Advanced Anti-Counterfeiting and Environmental Monitoring was written by Zhang, Xin;Cheng, Yaohui;You, Jingxuan;Zhang, Jinming;Wang, Yirong;Zhang, Jun. And the article was included in ACS Applied Materials & Interfaces in 2022.Electric Literature of C11H20N2 This article mentions the following:

Organic phosphorescence materials have many unique advantages, such as a large Stokes shift, high signal-to-noise ratio, and no interference from background fluorescence and scattered light. But, they generally lack responsiveness. Herein, we developed a new type of biopolymer-based phosphorescence materials with excellent processability and irreversible humidity-responsiveness, via introducing the imidazolium cation to cellulose chain. In the resultant cellulose derivatives, the imidazolium cation promotes the intersystem crossing, meanwhile the cation, chloride anion, and hydroxyl group form multiple hydrogen bonding interactions and electrostatic attraction interactions, which successfully inhibit the nonradiative transitions. As a result, the ionic cellulose derivatives exhibit green phosphorescence at room temperature and can be processed into phosphorescent films, coatings, and patterns. More interestingly, their phosphorescence emission changes when the different processing solvents are used. The ionic cellulose derivatives processed with acetone have a negligible phosphorescence, while they give an irreversible humidity-responsive phosphorescence, which means that the ionic cellulose derivatives processed with acetone exhibit significantly enhanced phosphorescence once they meet water vapor. Such novel irreversible responsive phosphorescence materials have huge potential in advanced anticounterfeiting, information encryption, mol. logic gates, smart tags, and process monitoring. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic Imidazolium Cation-Based Ionic Liquids Show Unexpected Interfacial Properties was written by Chen, Zhichao;Morales-Collazo, Oscar;Brennecke, Joan F.. And the article was included in Langmuir in 2020.Electric Literature of C11H20N2 This article mentions the following:

Virtually, every investigation and application of ionic liquids (ILs) involves gas-liquid, liquid-liquid, and liquid-solid interactions. Therefore, understanding the behavior of ILs at those interfaces is critical In this work, we studied the interfacial properties of protic and aprotic ILs with N-alkylimidazolium and 1-alkyl-3-methylimidazolium as cations and bis(trifluoromethylsulfonyl)imide, methanesulfonate, and trifluoromethanesulfonate as anions. The surface tension of these ILs is measured with the pendant drop method in a temperature range of 293.15-343.15 K and at atm. pressure. The contact angle measurements are performed at 293.15 K on three solid substrates: polytetrafluoroethylene, glassy carbon, and platinum. Dispersive and nondispersive components of the IL surface energy are determined from the exptl. data using Fowkes theory. The most interesting result is that the protic ILs have lower surface tension and smaller contact angles than the equivalent aprotic ILs, despite the presence of high charge d. on the proton associated with one of the nitrogens of the cation. Higher charge d. on the anion results in a higher surface tension, and decreasing surface tension and contact angles are observed for increasing alkyl chain length on the cation. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Correlation and prediction of ionic liquid viscosity using Valderrama-Patel-Teja cubic equation of state and the geometric similitude concept. Part I: Pure ionic liquids was written by Valderrama, Jose O.;Cardona, Luis F.;Rojas, Roberto E.. And the article was included in Fluid Phase Equilibria in 2019.Reference of 404001-48-5 This article mentions the following:

A generalized viscosity equation of state including a single adjustable parameter for correlating and estimating the viscosity of ionic liquids at different temperatures and pressures is proposed. The similar shape and form of the curves (isotherms and saturation lines) observed in a d.-pressure-temperature plot and in a viscosity-pressure-temperature plot (ρTP and μTP plots), known as geometrical similitude, is the basis of the proposed model. Viscosity data available in the literature has been gathered, analyzed, and selected to finally construct a database of consistent data to obtain a general model. The generalized equation of state model includes a number of parameters that are determined by fitting the model using the selected exptl. viscosity data of different types of ionic liquids In total, 3857 viscosity data for 187 ionic liquids in the temperature range of 253-573 K and pressures from 1.0 up to 1500 bar have been considered. The generalized viscosity model has been compared with other existing approaches and results show that the new viscosity cubic equation of state model provides accurate and consistent results taking in account the simplicity of the generalized expressions, which contains only one adjustable parameter for each ionic liquid In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Reference of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of cyclodextrin based hydrogel nanocarriers for enhanced solubility of candesartan cilexetil was written by Aslam, Afeefa;Bashir, Sajid;Sarfraz, Rai M.;Ahmad, Shahbaz. And the article was included in Latin American Journal of Pharmacy in 2019.COA of Formula: C33H34N6O6 This article mentions the following:

Nanoparticles are considered a useful tool for improving properties of poorly soluble active ingredients. In this work, successful efforts have been performed for solubility enhancement of candesartan. pH-sensitive hydroxypropyl β-cyclodextrin-poly acrylic acid (HPβCD-pAA) hydrogel nanoparticles were developed. Candesartan cilexetil, practically insoluble in water, was used as a model drug. Different formulations were prepared by free radical polymerization Developed nanoparticles were subjected to FTIR, DSC, TGA, PXRD, SEM, size anal., equilibrium swelling ratio (q), solubility studies, and in vitro drug release studies. pH dependent higher swelling and drug release was observed at pH 6.8 in less than 3 h. Solubility was improved up to 167.4 and 233.1 μg/mL in distilled water and PBS (pH 6.8) as compared to pure drug. The efficient preparation, high solubility, improved dissolution and pH responsive nature of prepared hydrogel nanoparticles can be a potential approach for delivery of poorly soluble drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5COA of Formula: C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quantitative estimation of intra-subject variability in bioequivalence studies of generic solid oral dosage forms by multiple regression analysis was written by Wada, Shigenori;Kagatani, Seiya;Nakagami, Hiroaki. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Intra-subject variability (CVintra), which determines the 90% confidence intervals and the number of subjects needed for assessment in bioequivalence studies, is generally investigated by using pilot study Results. However, conducting pilot studies greatly affects the speed and cost of drug development. In this study, we performed multiple regression anal. of the major factors that predict the extent of the CVintra of pharmacokinetic parameters by using 4 quant. variables (drug solubility, variability of the peak drug concentration [Cmax] or area under the drug plasma concentration vs. time curve [AUC], bioavailability, and elimination half-life), which were obtained from a database of the results of bioequivalence studies conducted by Nihon Generic Co., Ltd. A total of 77 studies [34 components] were included. From this anal., we confirmed that multiple regression equations can be used to estimate 3 kinds of %CVintra values with high correlation coefficients (r = 0.8971 for the Cmax of all drug types, r = 0.9739 for the AUC of renal excretion-type drugs, and r = 0.5368 for the AUC of non-renal excretion-type drugs). When the predicted equations were applied to newly planned bioequivalence studies (2 studies [2 components]) without pilot studies, it was verified that the %CVintra of the Cmax and AUC could be estimated with a predicted value of ±5. Further, both formulations were found to be bioequivalent in term of the Cmax and AUC, with 90% confidence intervals of sufficient power. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates was written by Sadowsky, Jack D.;Pillow, Thomas H.;Chen, Jinhua;Fan, Fang;He, Changrong;Wang, Yanli;Yan, Gang;Yao, Hui;Xu, Zijin;Martin, Shanique;Zhang, Donglu;Chu, Phillip;dela Cruz-Chuh, Josefa;ODonohue, Aimee;Li, Guangmin;Del Rosario, Geoffrey;He, Jintang;Liu, Luna;Ng, Carl;Su, Dian;Lewis Phillips, Gail D.;Kozak, Katherine R.;Yu, Shang-Fan;Xu, Keyang;Leipold, Douglas;Wai, John. And the article was included in Bioconjugate Chemistry in 2017.Formula: C6H8N2O2S This article mentions the following:

Conjugation of small mol. payloads to specific cysteine residues on proteins via a disulfide bond represents an attractive strategy to generate redox-sensitive bioconjugates, which have value as potential diagnostic reagents or therapeutics. Advancement of such “direct-disulfide” bioconjugates to the clinic necessitates chem. methods to form disulfide connections efficiently, without byproducts. The disulfide connection must also be resistant to premature cleavage by thiols prior to arrival at the targeted tissue. We show here that commonly-employed methods to generate direct disulfide-linked bioconjugates are inadequate for addressing these challenges. We describe our efforts to optimize direct-disulfide conjugation chem., focusing on the generation of conjugates between cytotoxic payloads and cysteine-engineered antibodies (i.e., THIOMAB antibody-drug conjugates, or TDCs). This work culminates in the development of novel, high-yielding conjugation chem. for creating direct payload disulfide connections to any of several Cys mutation sites in THIOMAB antibodies or to Cys sites in other biomols. (e.g., human serum albumin and cell-penetrating peptides). We conclude by demonstrating that hindered direct disulfide TDCs with two Me groups adjacent to the disulfide, which have heretofore not been described for any bioconjugate, are more stable and more efficacious in mouse tumor xenograft studies than less hindered analogs. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analytical method development and validation of Ramipril and Candesartan cilexetil in synthetic mixture was written by Nagar, Akhil;Deore, Sumit;Bendale, Atul;Kakade, Rajanikant;Sonawane, Chetankumar. And the article was included in Innovations in Pharmaceuticals and Pharmacotherapy in 2020.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

The aim of the study was to develop a rapid, accurate, and precise ratio spectra derivative spectroscopic high-performance liquid chromatog. method and validated for the estimation of Ramipril (RAM) and Candesartan cilexetil (CAN) in synthetic mixture The estimation of RAM, CAN (6μg/mL) was used as a devisor and for the estimation of CAN, RAM (5μg/mL) used as a devisor. The wavelengths selected for quant. estimation were 331 nm for RAM and 231 nm and for CAN. Results: The result for validation shows that linearity of the developed method was 0.9976 and 0.9994 in the range of 5-10μg/mL and 6-16μg/mL for RAM and CAN, resp. Phenomenex C18 column (250 mmx4.6 mm, 5μm particle size) column was used. Acetonitrile:water (0.5% TEA, pH 4.5 adjusted with 10% orthophosphoric acid) (85:15 volume/volume) as a mobile phase, flow rate 1 mL/min and detection carried out at 220 nm. The retention time of RAM and CAN was 3.607 and 5.613 min, resp. Linearity of the developed method was found to be 0.9956 and 0.9974 in the range of 0.5-0.9μg/mL and 1.60-2.88μg/mL for RAM and CAN, resp. From the mentioned results, we can conclude that the developed methods were validated successfully as per the ICH guideline and are accurate, robust, and precise. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhanced Anti-Bacterial Activity of Non-Antibacterial Drug Candesartan Cilexetil by Delivery through Polymeric Micelles was written by Kareem, Faheem;Abdul-Karim, Rubina;Maharjan, Rukesh;Shah, Muhammad Raza;Simjee, Shabana U.;Khan, Khalid M.;Malik, Muhammad Imran. And the article was included in ChemistrySelect in 2020.Electric Literature of C33H34N6O6 This article mentions the following:

Candesartan Cilexetil (CC) is a prodrug of candesartan and an angiotensin II receptor antagonist. It is used as a drug for different diseases like myocardial infarction, hypertension, and heart failure. The applicability of CC is impeded due to its poor water solubility, low permeability, and low bioavailability. This study is targeted to improve the efficacy and bioavailability of CC by its delivery through MeO-PEO_5K-PCL micelles. The effect of length of hydrophobic block (PCL) on size of the micelles, drug encapsulation efficiency, and drug release behavior is evaluated. MeO-PEO_5K-PCL based micelles were prepared by solvent evaporation method. The size of PMs was determined by dynamic light scattering, morphol. by at. force microscopy, and critical micelles concentration by fluorescence method. Encapsulation efficiency and drug release behaviors of MeO-PEO_5K-PCL based PMs were evaluated by UV-visible spectroscopy and dispersion method, resp. The size of micelles increased and drug release rate decreased with increase in the length of PCL block. Maximum encapsulation efficiency of 96.42% for CC is achieved with ABCs having equal PEO and PCL block lengths. A comparison of antibacterial activity of CC in pure form and encapsulated in PMs against MRSA is conducted. The MIC₅₀ for CC loaded PMs has decreased to more than half in comparison to pure drug. AFM based morphol. anal. also confirmed the decrease in MIC₅₀ by delivery through PMs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem