Month: January 2023

Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase was written by Urban, Milan;Joubert, Nicolas;Hocek, Michal;Alexander, Richard E.;Kuchta, Robert D.. And the article was included in Biochemistry in 2009.Related Products of 4887-83-6 This article mentions the following:

Herpes simplex virus-1 primase misincorporates the natural NTPs at frequencies of around one error per 30 NTPs polymerized, making it one of the least accurate polymerases known. We used a series of nucleotide analogs to further test the hypothesis that primase requires Watson-Crick hydrogen bond formation to efficiently polymerize a NTP. Primase could not generate base pairs containing a complete set of hydrogen bonds in an altered arrangement (isoguanine/isocytosine) and did not efficiently polymerize dNTPs completely incapable of forming Watson-Crick hydrogen bonds opposite templating bases incapable of forming Watson-Crick hydrogen bonds. Similarly, primase did not incorporate most NTPs containing hydrophobic bases incapable of Watson-Crick hydrogen bonding opposite natural template bases. However, 2-pyridone NTP and 4-methyl-2-pyridone NTP provided striking exceptions to this rule. The effects of removing single Watson-Crick hydrogen bonding groups from either the NTP or templating bases varied from almost no effect to completely blocking polymerization depending both on the parental base pair (G/C vs. A/T/U) and which base pair of the growing primer (second, third, or fourth) was examined Thus, primase does not absolutely need to form Watson-Crick hydrogen bonds to efficiently polymerize a NTP. Addnl., we found that herpes primase can misincorporate nucleotides both by misreading the template and by a primer-template slippage mechanism. The mechanistic and biol. implications of these results are discussed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Related Products of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Experimental memory disorders and their pharmacological correction was written by Shabanov, P. D.. And the article was included in Vestnik Akademii Meditsinskikh Nauk SSSR in 1985.Name: 1H-Imidazole-4-carboxamide This article mentions the following:

The antiamnesic action of a variety of neurotropic drugs on 2 models of memory disorders (electronconvulsive shock and mech. brain injury) was studied in rats. GABA (200 mg/kg) and 1-methyl-3,4-di-(N-methylcarbamoyl)-pyrazole (10 μg/kg) were the most potent drugs inhibiting amnesia for passive avoidance. Piracetam (100 mg/kg) and etimazole (1.5 mg/kg) were compared for effects on learning and memory of the drinking conditioned reflex under conditions of RNA synthesis inhibition by actinomycin D. Neither compound affected learning but facilitated it after actinomycin D administration. Both drugs also increased memory retention. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Name: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results was written by Boulmier, Amandine;Feng, Xinxin;Oms, Olivier;Mialane, Pierre;Riviere, Eric;Shin, Christopher J.;Yao, Jiaqi;Kubo, Tadahiko;Furuta, Taisuke;Oldfield, Eric;Dolbecq, Anne. And the article was included in Inorganic Chemistry in 2017.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

The authors synthesized a series of polyoxometalate-bisphosphonate complexes containing Mo^VIO₆ octahedra, zoledronate, or an N-alkyl (n-C₆ or n-C₈) zoledronate analog, and in two cases, Mn as a heterometal. Mo₆L₂ (L = Zol, ZolC₆, ZolC₈) and Mo₄L₂Mn (L = Zol, ZolC₈) were characterized by using single-crystal x-ray crystallog. and/or IR spectroscopy, elemental and energy dispersive x-ray anal. and ³¹P NMR. The authors found promising activity against human non-small cell lung cancer (NCI-H460) cells with IC₅₀ values for growth inhibition of ∼5 μM per bisphosphonate ligand. The effects of bisphosphonate complexation on IC₅₀ decreased with increasing bisphosphonate chain length: C₀ ≈ 6.1×, C₆ ≈ 3.4×, and C₈ ≈ 1.1×. The authors then determined the activity of one of the most potent compounds in the series, Mo₄Zol₂Mn(III), against SK-ES-1 sarcoma cells in a mouse xenograft system finding a ∼5× decrease in tumor volume than found with the parent compound zoledronate at the same compound dosing (5 μg/mouse). Overall, the results are of interest since the authors show for the first time that heteropolyoxomolybdate-bisphosphonate hybrids kill tumor cells in vitro and significantly decrease tumor growth, in vivo, opening up new possibilities for targeting both Ras as well as epidermal growth factor receptor driven cancers. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Studies on the solubility of terephthalic acid in ionic liquids was written by Matuszek, Karolina;Pankalla, Ewa;Grymel, Aleksander;Latos, Piotr;Chrobok, Anna. And the article was included in Molecules in 2020.Synthetic Route of C4H7ClN2 This article mentions the following:

Low solubility of terephthalic acid in common solvents makes its industrial production very difficult and not environmentally benign. Ionic liquids are known for their extraordinary solvent properties, with capability to dissolve a wide variety of materials, from common solvents to cellulose, opening new possibilities to find more suitable solvents for terephthalic acid. This work presents studies on the solubility of terephthalic acid in ionic liquids, and demonstrates that terephthalic acid is soluble in ionic liquids, such as 1-ethyl-3-methylimidazolium diethylphosphate, 1-butyl-3-methylimidazolium acetate, and dialkylimidazolium chlorides up to four times higher than in DMSO. Addnl., the temperature effect and correlation of ionic liquid structure with solubility efficiency are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation development of oral liquisolid systems of poorly water-soluble drug, hydrochlorothiazide, using mixed solvency concept and their evaluations was written by Wadhwani, Harshal;Maheshwari, R. K.. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2021.Recommanded Product: 145040-37-5 This article mentions the following:

The present work is aimed to enhance the drug loading capacity in a liquisolid system, decreasing the required volume of nonvolatile solvent due to enhanced solubility of a drug in nonvolatile solvent using the mixed solvency concept. Hydrochlorothiazide was selected as a model poorly water-soluble drug for exploring the mixed solvency concept to enhance the solubility and hence to enhance the release rate of the drug. The proposed formulation is aimed to enhance the solubility of hydrochlorothiazide by employing the mixed solvency concept and to develop the fast-release capsule of hydrochlorothiazide using the liquisolid technique. The prepared liquisolid dosage form was tested for flow properties, thin layer chromatog., drug excipient interaction studies, drug content determination, disintegration time study, and dissolution studies. The comparative dissolution studies were performed and it was observed that the formulated capsule containing liquisolid formulation released 81.09% of the drug within 10 min, and only 56.25% drug was released from the marketed tablet formulation within 10 min. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4-Aminoimidazole-5-carboxamide, precursor of the purines in E. coli was written by Ben-Ishai, Ruth;Volcani, Benjamin;Bergmann, Ernst D.. And the article was included in Archives of Biochemistry and Biophysics in 1951.Reference of 26832-08-6 This article mentions the following:

In the presence of only 4 γ/cc. of any of the purine bases, which by themselves gave only 30% growth, 4-aminoimidazole-5-carboxamide (I) (30γ) gave full growth. p-Aminobenzoic acid (0.1 γ/cc.) and 0.005 γ/cc. folic acid had no effect on the rate at which I was utilized but B₁₂ (0.0002 γ/cc.) increased the rate of utilization. B₁₂ had no effect in media containing adenine or other purine bases. The formyl derivative of I was more effective than I. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Reference of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels-Alder was written by Mansot, Justine;Lauberteaux, Jimmy;Lebrun, Aurelien;Mauduit, Marc;Vasseur, Jean-Jacques;Marcia de Figueiredo, Renata;Arseniyadis, Stellios;Campagne, Jean-Marc;Smietana, Michael. And the article was included in Chemistry – A European Journal in 2020.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

While artificial cyclases hold great promise in chem. synthesis, this work presents the first example of a DNA-catalyzed inverse electron-demand hetero-Diels-Alder (IEDHDA) between dihydrofuran and various α,β-unsaturated acyl imidazoles. The resulting fused bicyclic O,O-acetals containing three contiguous stereogenic centers I (R = Me, c-hexyl, Ph, etc.) are obtained in high yields (up to 99%) and excellent diastereo- (up to >99:1 dr) and enantioselectivities (up to 95% ee) using a low catalyst loading. Most importantly, these results show that the concept of DNA-based asym. catalysis can be expanded to new synthetic transformations offering an efficient, sustainable, and highly selective tool for the construction of chiral building blocks. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Molybdenum(II) Complexes with α-Diimines: Catalytic Activity in Organic and Ionic Liquid Solvents was written by Saraiva, Marta S.;Nunes, Carla D.;Felix, Vitor;Ribeiro, Ana P. C.;de Castro, Carlos Nieto;Calhorda, Maria Jose. And the article was included in European Journal of Inorganic Chemistry in 2018.Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The new [MoX(η³-C₃H₅)(CO)₂(α-diimine)] complexes with: (i) X = Br or triflate and α-diimine = 1,10-phenanthroline (phen) and dipyridophenazine (dppz); and (ii) X = Br and α-diimine = phen and dppz, with several substituents, are synthesized and characterized. The structures of [MoBr(η³-C₃H₅)(CO)₂(Cl-phen)] and [Mo(CF₃SO₃)(η³-C₃H₅)(CO)₂(dppz)] are determined by using single-crystal X-ray diffraction. These and three complexes of 2,2′-bipyridyl (bpy), and its two derivatives with Me and ^tBu substituents, are tested in the homogeneous catalytic epoxidation of several olefins in dichloromethane, exhibiting, in general, a good selectivity towards the resp. epoxide and relatively low TOFs. For the first time, the oxidation of cis-cyclooctene with some of these catalysts is also conducted in a variety of room-temperature ionic liquids (RTILs). In the presence of [MoBr(η³-C₃H₅)(CO)₂(phen)], the conversions, in general, increase, compared with the reactions in organic solvents. Interestingly, different chemoselectivity is found when [C₆mim][Ntf₂] and [C₂mim][FAP] are used with diol (24-26 %). On the other hand, [MoBr(η³-C₃H₅)(CO)₂(L)] (L = Me-phen or dppz) exhibits much lower conversions in the RTILs tested than in common organic solvents. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium Ionic Liquids as Potential Anti-Candida Inhibitors: QSAR Modeling and Experimental Studies was written by Hodyna, Diana;Kovalishyn, Vasyl;Rogalsky, Sergiy;Blagodatnyi, Volodymyr;Metelytsia, Larisa. And the article was included in Current Drug Discovery Technologies in 2016.Recommanded Product: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Quant. structure-activity relationships (QSAR) of imidazolium ionic liquids (ILs) as inhibitors of C. albicans collection strains (IOA-109, KCTC 1940, ATCC 10231) have been studied. Predictive QSAR models were built using different descriptor sets for a set of 88 ionic liquids with known min. inhibitory concentrations (MIC) against C. albicans. We applied the state-of-the-art QSAR methodologies such as WEKA Random Forest (RF) as a binary classifier, Associative Neural Networks (ASNN) and k-Nearest Neighbors (k-NN) to build continuum non-linear regression models. The obtained models were validated using a 5-fold cross-validation approach and resulted in the prediction accuracies of 80% ± 5.0 for the classification models and q2 = 0.73-0.87 for the non-linear regression models. Biol. testing of newly synthesized 1,3-dialkylimidazolium ionic liquids with predicted activity was performed by disco-diffusion method against C. albicans ATCC 10231 M885 strain and clin. isolates C. albicans, C. krusei and C. glabrata strains. The high percentage of coincidence between the QSAR predictions and the exptl. results confirmed the high predictive power of the developed QSAR models within the applicability domain of new imidazolium ionic liquids In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Recommanded Product: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chelated Assisted Metal-Mediated N-H Bond Activation of β-Lactams: Preparation of Irida-, Rhoda-, Osma-, and Ruthenatrinems was written by Casarrubios, Luis;Esteruelas, Miguel A.;Larramona, Carmen;Muntaner, Jaime G.;Olivan, Montserrat;Onate, Enrique;Sierra, Miguel A.. And the article was included in Organometallics in 2014.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

2-Azetidinones substituted with pyridine (2a), quinoline (2b), isoquinoline (2c), imidazole (2d), and benzimidazole (2e) at the 4-position of the four-membered ring have been prepared in order to synthesize tribactams containing a transition metal and its associated ligands, L_nM, at the 2-position of the tricyclic skeleton. The developed procedure is compatible with a wide range of transition-metal starting complexes. Thus, the iridium and rhodium dimers [M(η⁵-C₅Me₅)Cl₂]₂ react with 2a–e, in the presence of sodium acetate, to afford irida- and rhodatrinems (1a–j) containing the half-sandwich d⁶ metal fragments M(η⁵-C₅Me₅)Cl (M = Ir, Rh). The reactions of [M(μ-OMe)(η⁴-COD)]₂ (M = Ir, Rh) with 2a lead to irida- and rhodatrinems (1k,l) with the d⁸ moieties M(η⁴-COD). The coordination sphere and oxidation state of the metal center in these compounds can be modified, without affecting the 2-azetidinone backbone, by substitution and oxidative addition reactions. As a proof of concept, metallatrinems with the M(CO)₂ (M = Ir (1m), Rh (1n)) and Ir(Me)I(CO)₂ (1o) units are also reported. Osmatrinems 1p,q containing the d⁴ metal fragment OsH₃(PⁱPr₃)₂ have been obtained starting from the d² hexahydride OsH₆(PⁱPr₃)₂, by reaction with 2a,b, whereas the treatment of the tetrahydroborate complexes MH(η²-H₂BH₂)(CO)(PⁱPr₃)₂ (M = Os, Ru) with 2a yields osma- and ruthenatrinems (1r,s) containing six-coordinate bis(phosphine) d⁶ metal fragments. The IR stretching frequency of the lactamic carbonyl, the bent angle between the five- and four-membered rings of the tricycle, and the N-CO bond length in the lactamic ring are clearly influenced by the L_nM fragment. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem