Month: January 2023

Bi-metallic zeolite imidazole framework nanofibers for the selective determination of Cd²⁺ ions was written by Girija, S.;Sankar, S. Sam;Thenrajan, T.;Kundu, Subrata;Wilson, J.. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2021.Related Products of 1632-83-3 This article mentions the following:

Cobalt zinc-zeolite imidazole framework (Co/Zn-ZIF) nanofibers are made via an electrospinning (ES) approach and tested for the detection of heavy metal cadmium ions. Electrostatically attracted cobalt and zinc ions are bound regularly on the surface of the ZIF network. The cobalt and zinc ions are organized with the ZIF network, which provides the sturdily bonded tetrahedral structure of Co/Zn-ZIF, giving essential steadiness to the composite material. Cyclic voltammetry revealed that the observed profile is reversible, and the catalytic behavior of the electrodes provided evidence of interfacial electron transfer between the nanofiber-modified GCE surface and the metal ions. Interestingly, a careful determination of Cd²⁺ ions within the range of 100 nM to 1 mM with a low limit detection of 27.27 nM was undertaken. The established heavy metal ion detector shows excellent anti-interference abilities toward the observed electroactive species, and it was successfully employed using a tap water sample for Cd²⁺ ion detection, where good results were observed In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Palladium-Catalyzed Synthesis of Fluorescent Benzo[4,5]imidazo[1,2-a]pyridines through Annulation Reaction of Benzimidazoles and Alkynyl Bromides with Internal Alkynes was written by Chen, Xin;Sun, Peng;Mo, Baichuan;Chen, Chunxia;Peng, Jinsong. And the article was included in Journal of Organic Chemistry in 2021.Reference of 4887-83-6 This article mentions the following:

An efficient synthesis of fused azapolycycles based on (benz)imidazole and pyridine scaffolds has been developed. In all cases, the first nucleophilic addition of (benz)imidazoles to alkynyl bromides in tert-pentyl alc. can proceed in a stereoselective manner to provide (Z)-N-(1-bromo-1-alken-2-yl)benzimidazoles at 110°C. Sequentially, these adducts containing alkenyl bromide can undergo Pd-catalyzed intermol. C-H annulation in the presence of internal alkynes in dimethylacetamide, affording fluorescent (benz)imidazole-fused pyridines in good to high yields. These compounds generally exhibit blue or green fluorescences (454-503 nm for solution states and 472-506 nm for solid states), and the fluorescence quantum yields remained in 0.19-0.89 and 0.02-0.74 for solution and solid states, resp. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On the stability of imidazolium and benzimidazolium salts in phosphoric acid based fuel cell electrolytes was written by Tang, Hongying;Aili, David;Geng, Kang;Gao, Jian;Li, Qingfeng;Li, Nanwen. And the article was included in Journal of Power Sources in 2021.Reference of 1632-83-3 This article mentions the following:

Polymers containing organic cations are considered as promising materials for phosphoric acid (PA) doped high temperature polymer electrolyte membranes (HT-PEMs) due to higher PA retention and wider operation temperature range. However, the thermal/acidic stability of the organic cations remains to be determined Herein, a series of model cations based on various (benz)imidazoliums are designed and prepared to assess the stability on mol. level under simulated operating conditions for HT-PEM fuel cell. NMR anal. indicates that C2, C4 and C5 substitutions show little effect on the stability while N1 and N2 substitutions show opposite effect. Among the N-functionalized derivatives, N, N-dimethyl (benz)imidazolium cations are fully stable while N-benzyl imidazoliums degraded severely due nucleophilic substitution with H₂PO₄^–. On this background, blend membranes based on fully methylated polybenzimidazole (PBI) are prepared, and the swelling is balanced by introducing pristine PBI. The proton conductivity of the PA doped blending membrane with IEC of 1.2 mmol g-1 reaches 165 mS cm^-1 and a peak power d. of 863 mW cm^-2 is demonstrated in H₂/O₂ fuel cell test. These results lay a solid foundation for designing and developing durable high-performance HT-PEMs and fuel cell devices for green energy conversion applications. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Allylic C-H Alkylation of Allyl Ethers with 2-Acylimidazoles was written by Wang, Tian-Ci;Fan, Lian-Feng;Shen, Yang;Wang, Pu-Sheng;Gong, Liu-Zhu. And the article was included in Journal of the American Chemical Society in 2019.Formula: C6H8N2O This article mentions the following:

An asym. allylic C-H alkylation of allyl ethers has been established by chiral phosphoramidite-palladium catalysis, affording a wide variety of functionalized chiral 2-acylimidazoles in moderate to high yields and with high levels of enantioselectivity. Moreover, this protocol could be applied to a concise asym. synthesis of a tachykinin receptor antagonist. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibition of hydrogen sulfide corrosion of steel by benzimidazole derivatives was written by Starchak, V. G.;Kosukhina, L. D.. And the article was included in Zashchita Metallov in 1989.Recommanded Product: 13060-24-7 This article mentions the following:

The influence was studied of benzimidazole and 2-alkylbenzimidazoles on the corrosion inhibition of steel 45 in acidic H₂S media by using a weight-loss method. The electrochem. method was used to study the corrosion of Armco Fe, and the polarization resistance of steel St. 3 was measured. Derivatives of benzimidazole, exhibiting synergism in H₂S media, significantly increase the corrosion resistance of steel. The mechanism of inhibition is basically related to blocking and ψ¹-effects. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Recommanded Product: 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The ultrasound-assisted synthesis of some novel fused-ring heterocyclic systems bearing structurally diverse benzazoles via a copper-catalyzed cross-coupling reaction was written by Karimi, Nafiseh;Mahboubi-Rabbani, Mohammad;Dastjerdi, Hossein Fasihi;Nematpour, Manijeh;Rezaee, Elham;Tabatabai, Sayyed Abbas. And the article was included in Monatshefte fuer Chemie in 2022.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

A novel ultrasonic-assisted process involving CuI-catalyzed intra-mol. C-H activation of benzazoles were developed. This methodol. offered affordable starting materials, mild reaction conditions, easy handling of the catalyst, a simple work-up process and short reaction times. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale was written by McCoy, Michael A.;Spicer, Dominique;Wells, Neil;Hoogewijs, Kurt;Fiedler, Marc;Baud, Matthias G. J.. And the article was included in Journal of Medicinal Chemistry in 2022.Synthetic Route of C9H9N3 This article mentions the following:

The canonical Wingless-related integration site signaling pathway plays a critical role in human physiol., and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional protein within this pathway and an attractive yet challenging therapeutic target, most notably in oncol. This has stimulated the search for potent small-mol. inhibitors binding directly to the β-catenin surface to inhibit its protein-protein interactions and downstream signaling. Here, we provide an account of the claimed (and some putative) small-mol. ligands of β-catenin from the literature. Through in silico anal., we show that most of these mols. contain promiscuous chem. substructures notorious for interfering with screening assays. Finally, and in line with this anal., we demonstrate using orthogonal biophys. techniques that none of the examined small mols. bind at the surface of β-catenin. While shedding doubts on their reported mode of action, this study also reaffirms β-catenin as a prominent target in drug discovery. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Synthetic Route of C9H9N3).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C9H9N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric Michael Addition of 2-Acetyl Azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex was written by Wang, Cong;Li, Nan;Zhu, Wen-Jing;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Journal of Organic Chemistry in 2019.Computed Properties of C6H8N2O This article mentions the following:

The first enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-(3-indolyl)nitroalkenes has been successfully achieved in the presence of a Co(II)/(imidazoline-oxazoline) complex as the catalyst. The reaction affords a series of CF₃– and 3-indole-containing adducts featuring a trifluoromethylated all-carbon quaternary stereocenter in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee). Furthermore, the functional groups in the adducts including C=O, NO₂, and the azaarene provide a large variety of useful transformations, leading to the formation of valuable intermediates such as optically active secondary alc., pyrroline, ester, and pyrrolidinone which all contain a 3-substituted indole and a trifluoromethylated all-carbon quaternary stereocenter. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Computed Properties of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid copolymerized polyurethane membranes for pervaporation separation of benzene/cyclohexane mixtures was written by Xi, Tao;Lu, Yingying;Ai, Xinyu;Tang, Lin;Yao, Lulu;Hao, Wentao;Cui, Peng. And the article was included in Polymer in 2019.Application of 915358-85-9 This article mentions the following:

Benzene and cyclohexane are both important raw materials in polymer chem. industry. However, they are hard to be separated via the traditional distilling methods. In this work, ionic liquid copolymerized waterborne polyurethane (IL-co-PU) membranes were proposed for the pervaporation separation of benzene/cyclohexane mixtures The results, including swelling rate, diffusion coefficients, partial flux, permeance and selectivity, showed that the IL-co-PU membranes could preferentially absorb and transfer benzene mols. rather than cyclohexane. The ILs might have functioned as facilitated transporter in the membranes. The permeation flux and separation factor of the IL-co-PU membranes increased simultaneously with the increase of IL contents. That is, these membranes had no trade-off between permeability and selectivity, which most of the polymer membranes suffered. With consideration of the good performance and easy handling property of the IL-co-PU membranes, they are of great potential in pervaporation separation of benzene/cyclohexane mixtures In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Application of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic Conjugate Additions of Carbonyl Anions under Neutral Aqueous Conditions was written by Myers, Michael C.;Bharadwaj, Ashwin R.;Milgram, Benjamin C.;Scheidt, Karl A.. And the article was included in Journal of the American Chemical Society in 2005.Electric Literature of C6H8N2O This article mentions the following:

The conjugate addition of carbonyl anions catalyzed by thiazolium salts that is fully operative under neutral aqueous conditions has been accomplished. The combination of α-keto carboxylates and thiazolium-derived zwitterions produces reactive carbonyl anions in a buffered protic environment that readily undergo conjugate additions to substituted α,β-unsaturated 2-acyl imidazoles. The scope of the reaction has been examined and found to accommodate various α-keto carboxylates and β-aryl substituted unsaturated 2-acyl imidazoles. The optimal precatalyst for this process is the com. available thiazolium salt, 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, a simple analog of thiamin diphosphate. In this process, no benzoin products from carbonyl anion dimerization are observed The corresponding 1,4-dicarbonyl compounds can be efficiently converted into esters and amides by way of activation of the N-methylimidazole ring via alkylation. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem