(6R,8S)-(2-Benzimidazolyl)hydroxymethylpenicillanic acids as potent antibacterial agents and β-lactamase inhibitors was written by Chen, Yuhpyng L.;Hedberg, Kirk;Guarino, Karen;Retsema, James A.;Anderson, Margaret;Manousos, Mary;Barrett, John. And the article was included in Journal of Antibiotics in 1991.Electric Literature of C9H8N2O This article mentions the following:
(6R,8S)-(2-Benzimidazolyl)hydroxymethylpenicillanic acids I [R = (un)substituted alkyl, alkenyl etc.] (24 compds) are potent antibacterial agents and β-lactamase inhibitors against Gram-pos. bacteria and Haemophilus influenzae. The (6R,8R)-isomers, the 6,6-spirobenzimidazolepenam alc., (7R,9S)-(1-vinyl-2-benzimidazolyl)hydroxymethylcephalosporanic acid, and 6β-(2-benzimidazolyl)aminopenicillanic acid are much less active as antibacterials or β-lactamase inhibitors. The syntheses and structure-activity relationships of these compounds are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Electric Literature of C9H8N2O).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C9H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem