Alimchandani, H. R. et al. published their research in Journal of Bacteriology in 1957 | CAS: 26832-08-6

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

The accumulation of 4-amino-5-imidazolecarboxamide in Escherichia coli was written by Alimchandani, H. R.;Sreenivasan, A.. And the article was included in Journal of Bacteriology in 1957.COA of Formula: C4H5N3O This article mentions the following:

The effects of pteroylglutamic acid (I), leucovorin (II), vitamin B12 (III), and methionine (IV) on the accumulation of 4-amino-5-imidazolecarboxamide by E. coli during sulfadiazine (V) bacteriostasis were studied. I and II were ineffective in reversing V growth inhibition or in influencing amine accumulation per unit growth to different degrees, III being the more effective. Amine accumulation, when expressed as a variable against growth, was more in the presence of IV and least in the control set without added III or IV, the III effect being intermediate. These observations are interpreted to mean that the primary effects of III or IV are on the growth and other aspects of cell metabolism that are interfered with by sulfonamides. Their involvement in amine to purine conversion is only indirect. Ethionine and a III oxidation product depressed growth, but no amine accumulation was observed. The inability of an E. coli mutant to accumulate the amine under conditions of deficiency of III or IV also suggested that these 2 metabolites are involved only indirectly in purine synthesis. 27 references. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6COA of Formula: C4H5N3O).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C4H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem