2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 22813-32-7
Biological characterization of novel nitroimidazole-peptide conjugates in vitro and in vivo was written by Bergmann, Ralf;Splith, Katrin;Pietzsch, Jens;Bachmann, Michael;Neundorf, Ines. And the article was included in Journal of Peptide Science in 2017.Product Details of 22813-32-7 This article mentions the following:
Recently, we reported on the design of a multimodal peptide conjugate useful as delivery platform for targeting hypoxic cells. A nitroimidazole (2-(2-nitroimidazol-1-yl)acetic acid, NIA) moiety, which is selectively entrapped in hypoxic cells, was coupled to a cell-penetrating peptide serving as the transporter. Furthermore, attachment of a bifunctional linker allowed the introduction of a diagnostic or therapeutic radiometal. However, although selective tumor accumulation could be detected in vivo, a fast renal clearance of the compound was observed The present study aims to improve the system by using the more proteolytically stable all-D version of the peptide carrier (DsC18), by attaching two NIA moieties instead of one (DsC18(NIA)2) to enhance the tumor uptake, and by incorporating the bifunctional chelator NODAGA instead of DOTA (NODAGA-DsC18(NIA)2) to optimize labeling chem. First, we characterized in vitro the novel all-D peptide compared with its parent L-version. Then, in order to investigate and compare the pharmacol. profiles of the peptides, these were radiolabeled with 64CuII and 68GaIII, and the biodistribution and kinetics were evaluated in vivo. Our results show the versatility of the D-peptide as cell-penetrating peptide and transporter. However, attaching two NIA groups modified the system in such a way that no selective tumor uptake could be observed compared with the peptide without NIA moieties. Still, this work highlights new pharmacokinetic data on the biodistribution of such compounds in vivo. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Product Details of 22813-32-7).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 22813-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem