Imidazole derivatives as inhibitors of cyclic nucleotide phosphodiesterases was written by Buchman, Russell;Heinstein, Peter F.;Wells, Jack N.. And the article was included in Journal of Medicinal Chemistry in 1974.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:
Opening the pyrimidine ring of methylxanthines markedly decreased their inhibitory activity toward phosphodiesterases. Four series of imidazole analogs of theophylline were prepared consisting of 1-substituted imidazole-4- and -5-carboxamides, 1,4-disubstituted imidazole-5-carboxamides, and 1-substituted-4-aminoimidazoles. The most potent inhibitors in these series were 4-benzylamino- [53525-67-0]and 4-benzylideneamino-5-(N-methylcarbamoyl)imidazole (I) [53525-53-4]. Substitution of a benzyl group in position 7 of theophylline confirmed some specificity for inhibition of hydrolysis of cyclic GMP. Most of the compounds were prepared by standard methods. 4-Amino-5-(N-methylcarbamoyl)imidazole [53525-66-9] was prepared by reduction of Et α-cyano-α-oximinoacetate [3849-21-6] with Al amalgam, reaction with MeNH2 to form α-amino-α-cyano-N-methylacetamide [50531-01-6], and cyclization with formamidine acetate [3473-63-0]. 4-(N-methylacetamido)-5-(N-methylcarbamoyl)imidazole [53525-54-5] was prepared by ring opening of 7-benzyltheophylline [1807-85-8] with KOH, followed by debenzylation with H2-Pd/C and acetylation. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1H-Imidazole-4-carboxamide
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem