An elegant method for the preparation of 3-cyanomethyl derivatives of imidazo[1,2-a]pyridines was written by Chinnapillai, Rajendiran;Nallamaddi, Ravikumar Reddy;Daliparthi, Eswaraprasad Rao;Poguri, Eswaraiah. And the article was included in Pharma Chemica in 2012.Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine This article mentions the following:
A series of 3-(cyanomethyl)imidazo[1,2-a]pyridines were synthesized by using ClCO2Et as alkylating agent for the generation of quaternary ammonium salts from 3-[(dimethylamino)methyl]imidazo[1,2-a]pyridines and subsequent cyanation. This novel process is elegant and simple with excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine).
N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem