Synthesis of 3-arylmethyl-2-oxindole derivatives and their effects on neuronal cell death was written by Furuta, Kyoji;Mizuno, Yosuke;Maeda, Masahide;Koyama, Hiroko;Hirata, Yoko. And the article was included in Chemical & Pharmaceutical Bulletin in 2017.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
Various 3-arylmethyl-2-oxindole derivatives were synthesized by the Knoevenagel condensation of oxindoles and aromatic aldehydes followed by palladium-mediated hydrogenation or hydride-reduction Further substituted derivatives at C-3 and/or N-1 of the oxindole skeleton were prepared from the condensation products. Their protective effect against neuronal cell death induced by oxidative stress was evaluated by lactate dehydrogenase assay. A structure-activity relationship study revealed that compounds with any of the dialkylamino, nitro or hydroxy groups on the 3-arylmethyl moieties elicit a superior potency to suppress cell death, while others were ineffective. Substitutions with less polar functional groups on the benzene or lactam ring of the oxindole skeleton pos., but not remarkably, affect the potency. In addition, the stereochem. at C-3 of the oxindole core was not a crucial factor for the neuroprotective activity of the compounds In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem