Silver(I)-mediated Hoogsteen-type base pairs was written by Megger, Dominik A.;Fonseca Guerra, Celia;Bickelhaupt, F. Matthias;Mueller, Jens. And the article was included in Journal of Inorganic Biochemistry in 2011.Recommanded Product: 4-Bromo-1H-benzoimidazole This article mentions the following:
Metal-mediated Hoogsteen-type base pairs are useful for the construction of DNA duplexes containing contiguous stretches of metal ions along the helical axis. To fine-tune the stability of such base pairs and the selectivity toward different metal ions, the availability of a selection of artificial nucleobases is highly desirable. In this study, we follow a theor. approach utilizing dispersion-corrected d. functional methods to evaluate a variety of artificial nucleobases as candidates for metal-mediated Hoogsteen-type base pairs. We focus on silver(I)-mediated Hoogsteen- and reverse Hoogsteen-type base pairs formed between 1-deaza- and 1,3-dideazapurine-derived nucleobases, resp., and cytosine. Apart from two coordinative bonds, these base pairs are stabilized by a hydrogen bond. We elucidate the impact of different substituents at the C6 position and the presence or absence of an endocyclic N3 nitrogen atom on the overall stability of a base pair and concomitantly on the strength of the hydrogen and coordinative bonds. All artificial base pairs investigated in this study are less stable than the exptl. established benchmark base pair C-Ag+-G. The base pair formed from 1,3-dideaza-6-methoxypurine is isoenergetic to the exptl. observed C-Ag+-C base pair. This makes 1,3-dideaza-6-methoxypurine a promising candidate for the use as an artificial nucleobase in DNA. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Recommanded Product: 4-Bromo-1H-benzoimidazole).
4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 4-Bromo-1H-benzoimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem