Catalytic asymmetric cyclopropanation of sulfoxonium ylides catalyzed by a chiral-at-metal rhodium complex was written by Ming, Siliang;Yang, Jian;Wu, Shi;Yao, Gang;Xiong, Hongwei;Du, Yu;Gong, Jun. And the article was included in Organic Chemistry Frontiers in 2022.SDS of cas: 85692-37-1 This article mentions the following:
An efficient asym. cyclopropanation of sulfoxonium ylides RC(O)CH:S(O)Me2 (R = Ph, 2-thienyl, 2-naphthyl, etc.) with α,β-unsaturated 2-acyl imidazoles I (R1 = Ph, 2-furyl, 2-naphthyl, etc.; R2 = Me, Ph, i-Pr) catalyzed by a chiral-at-metal rhodium complex has been developed. The enantioenriched cyclopropane derivatives II bearing three contiguous tertiary stereocenters were obtained in generally high yields (up to 98%) with excellent stereoselectivities (up to > 20:1 dr, > 99% ee). Remarkably, as low as 0.1 mol% of the chiral Rh(III) complex can catalyze a scale-up reaction with excellent yield and enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1SDS of cas: 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem