Separation of nitroimidazoles by reversed-phase high-pressure liquid chromatography was written by Sithole, Bishop B.;Guy, Robert D.. And the article was included in Talanta in 1986.Quality Control of 1-Methyl-4-nitroimidazole This article mentions the following:
A mixture of 8 N-substituted and unsubstituted nitroimidazoles was separated by high-pressure liquid chromatog. with 5% EtOH as the eluent. Compounds with the same capacity ratios were selectively detected electrochem. by differential pulse polarog. with a hanging Hg drop electrode (HMDE). The HMDE detector had higher detection limits than the photometric detector set at 315 nm. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Quality Control of 1-Methyl-4-nitroimidazole).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Quality Control of 1-Methyl-4-nitroimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem