Effects of imidazo[1,2-a]benzimidazole derivatives on gastric secretion and the antiulcer action was written by Spasov, A. A.;Kovalev, G. V.;Bakumov, P. A.;Reshetov, M. E.;Anisimova, V. A.;Avdyunina, N. I.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1990.Synthetic Route of C9H9N3 This article mentions the following:
Experiments on rats showed that of 16 studied imidazo [1,2-a] benzimidazole derivatives only the compounds with Ph at C-2 and a N-containing radical at N-9 inhibit gastric acid secretion. The binding of a methoxy group to Ph, replacement by its adamantyl, displacement of the N-containing substituent to N-1 or its substitution were found to decrease or stop the inhibiting action of these substances on gastric parietal cells. Dihydrochloride of 2-phenyl-9(β-diethylaminoethyl)imidazo[1,2-a]benzimidazole was more potent than cimetidine and omeprazole in inhibiting gastric acid secretion and pepsin output, and in exerting an antiulcer action. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Synthetic Route of C9H9N3).
2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C9H9N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem