Palladium Catalyzed Electrophilic C2-Arylation of Azoles by Aryltriazenes in Ionic Liquid Promoted by Acidic Ionic Liquid was written by Sutar, Suraj M.;Savanur, Hemantkumar M.;Patil, Chidanand;Prabhala, Pavankumar;Aridoss, Gopalakrishnan;Kalkhambkar, Rajesh G.. And the article was included in ChemistrySelect in 2020.Application of 1632-83-3 This article mentions the following:
A green C-H bond activation of azole based bio-pertinent substrates such as benzoxazole, benzothiazole, benzimidazole, etc. are accomplished using readily prepared 1-aryltriazenes RN=NNR1R2 (R = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.; R1 = R2 = Et; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-) as arylating agent. Under an optimized condition employing Pd(OAc)2 and CuI in either hydrophilic [Bmim][BF4] or hydrophobic [Bmim][PF6] IL medium with [BMIM(SO3H)][OTf] as a promoter, these arylation reactions proceeded smoothly to afford 2-aryl substituted azoles I (X = O, S, NCH3, NC6H5, 4-CH3C6H4N; R3 = H, Me; R4 = H, NH2, Cl, CH3) and 2-(p-tolyl)thiazole in acceptable to better yields besides noticeable functional group tolerance. The prospective for recovery and re-use of ionic liquid solvent is demonstrated. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 1632-83-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem