Organosodium compounds of N-substituted benzimidazole was written by Tertov, B. A.;Koblik, A. V.;Avdyunina, N. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1971.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
Reaction of I with R1COR2 in cold toluene or benzene gave the corresponding II. II (R, R1, R2, and yield given): Me, H, Ph, 67; Me, H, p-Me2NC6H4, 58; Me, H, m-O2NC6H4, 20; Me, Me, Ph, 48; Pr, H, p-Me2NC6H4, 57; Ph, H, 3,4-(MeO)2C6H3, 72. I (R=Me) treated with ethylene oxide in toluene at -15° gave 43% 1-methyl-2-(β-hydroxyethyl)benzimidazole. Similarly prepared were ∼30 other II analogs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem