Month: February 2023

Syntheses of 伪,尾-unsaturated ketones starting from vinylic and allylic Grignard reagents via 2-imidazolylmethanol intermediates was written by Hayakawa, Satoshi;Michiue, Toru;Okamoto, Masao;Hatakeyama, Shoko;Ohta, Shunsaku. And the article was included in Heterocycles in 1988.Recommanded Product: 85692-37-1 This article mentions the following:

The title unsaturated ketones, e.g., E-RCOCH:CHR¹ [I; R = R¹ = Ph; R = Me(CH₂)₅, Me₂C:CHCH₂CH₂CHMeCH₂, R¹ = Me] were prepared from acylimidazoles II and R¹CH:CHBr (III). Thus, Grignard reaction of II and III gave 92-100% imidazolylmethanols IV. Quaternization of IV with Me₂SO₄ followed by elimination with K₂CO₃ gave 87-90% I. Similarly, Grignard reactions of II [R = Me(CH₂)₅, cyclohexyl, Ph] with R²CH:CHCH₂Cl (R² = H, Me, Ph) gave hydroxyimidazoles V which were cleaved to give RCOCHR²CH:CH₂. Acidic isomerization gave RCOCR²:CHMe. This methodol. was used to prepare (卤)-(ar)-turmerone 4-MeC₆H₄CHMeCH₂COCH:CMe₂ in 5 steps from II (R = Me), p-MeC₆H₄CHO, and CH₂:CMeCH₂Cl. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The mutagenic action of nitroimidazoles. IV. A comparison of the mutagenic action of several nitroimidazoles and some imidazoles was written by Voogd, C. E.;Van der Stel, J. J.;Jacobs, J. J. J. A. A.. And the article was included in Mutation Research, Genetic Toxicology Testing in 1979.COA of Formula: C4H5N3O2 This article mentions the following:

When tested with Klebsiella聽pneumoniae and (or) Salmonella聽typhimurium, 31 of 33 tested nitroimidazoles were mutagenic, whereas of 18 other tested imidazoles without a nitro group, only 2 were mutagenic. Several of the substances tested for mutagenicity had antimicrobial action, but no direct relation between antimicrobial action, growth inhibition, and mutagenicity was observed A relation between the chem. structure and mutagenic action was observed for nitroimidazoles of a more complex chem. structure. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1COA of Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adjacent lone pair (ALP) effects in heteroaromatic systems. 2. Isotope exchange of ring hydrogens in nitro- and fluoroimidazoles was written by Takeuchi, Yoshio;Kirk, Kenneth L.;Cohen, Louis A.. And the article was included in Journal of Organic Chemistry in 1978.Recommanded Product: 3034-41-1 This article mentions the following:

The ring protons of nitro- and fluoroimidazoles (and their N-Me derivatives) undergo base-catalyzed exchange in D₂O by a combination of carbanion (C) and ylide (Y) pathways, which involve proton abstraction from the neutral imidazole species and from the imidazolium ion, resp. In 4-substituted imidazoles, C exchange occurs more readily at C-5 than at C-2, log k_C correlating with 蟽_o掳 for the NH- and with 蟽_p掳 for the N-Me series. For 1-methyl-4-nitroimidazole, t_1/2 = 2 min at C-5 (50掳, 0.2 N NaOD). In 1-methyl-5-X-imidazoles, exchange at C-4 occurs only via the Y pathway, carbanion formation in the neutral species being retarded by the adjacent lone pair (ALP) effect at N-3. The same effect is seen in the lack of C exchange at C-4 in 1-methylimidazoles. The ALP effect is considerably weaker or nonexistent at C-2. Most exchanges across the ring show correlations of log k with 蟼_m掳. 4-Alkylimidazoles (but not 1,4-dialkylimidazoles) show enhanced C exchange at C-5, which may result from the existence of a trace concentration of the ketimine tautomer. Enhanced exchange at C-5 in 2-fluorohistidine is ascribed to a combination of the ketimine effect, C exchange involving catalysis by OH and intramol. general-base catalysis by the side-chain primary-amine function. The use of buffer catalysis for the T labeling of poorly reactive imidazoles is described. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Estimation of Heat Capacity of 143 Pure Ionic Liquids Using Artificial Neural Network was written by Azadfar, Roohollah;Shaabanzadeh, Masoud;Hashemi-Moghaddam, Hamid;Nafchi, Abdorreza Mohammadi. And the article was included in International Journal of Thermophysics in 2022.COA of Formula: C18H31F6N3O4S2 This article mentions the following:

Based on artificial neural network (ANN), a new model is presented to estimate the heat capacity of pure ionic liquids A database for the heat capacity of ionic liquids created by extracting exptl. data from literature covering the period from 1971 to 2021 is reported. With the presented approach, heat capacity is calculated and evaluated by source data bank for 7059 data points of 143 ionic liquids The accuracies of new ANN model are evaluated by comparing with the most commonly used correlations in the literatures, and the results reveal that the proposed network provides more accurate results than other literature correlations considered in this work. The average absolute percentage deviation from the new model is only 1.14%. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5COA of Formula: C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

1-Ethyl-2,3-dimethylimidazolium paramagnetic ionic liquids with 3D magnetic ordering in its solid state: synthesis, structure and magneto-structural correlations was written by Garcia-Saiz, Abel;de Pedro, Imanol;Vallcorba, Oriol;Migowski, Pedro;Hernandez, Ignacio;Fernandez Barquin, Luis;Abrahams, Isaac;Motevalli, Majid;Dupont, Jairton;Gonzalez, Jesus Antonio;Fernandez, Jesus Rodriguez. And the article was included in RSC Advances in 2015.Product Details of 92507-97-6 This article mentions the following:

Two novel paramagnetic ionic liquids, comprised of a 1-ethyl-2,3-dimethylimidazolium (Edimim) cation and a tetrahaloferrate(III) (FeX₄) (X = Cl and Br) anion were synthesized and characterized by thermal, structural, Raman spectroscopy and magnetic studies. The crystal structures, determined by synchrotron X-ray powder diffraction and single crystal X-ray diffraction at 100 K for Edimim[FeCl₄] and Edimim[FeBr₄] resp., are characterized by layers of cations (in non-planar configuration) and anions stacked upon one another in a three-dimensional (3D) manner with several non-covalent interactions: halide-halide, hydrogen bond and anion-蟺. Magnetization measurements show the presence of three-dimensional antiferromagnetic ordering below the N茅el temperature (T_N) with the existence of a noticeable magneto-crystalline anisotropy in the bromide compound The corresponding magneto-structural correlations evidence that the 3D magnetic ordering mainly takes place via Fe-X路路路X-Fe (X = Cl and Br) interactions, displaying a higher superexchange magnetic interaction between the planes. Comparison with the Emim[FeX₄] (X = Cl and Br) phases (Emim: 1-ethyl-3-methylimidazolium) reveals that the methylation at the C(2) position onto the imidazolium cation ring causes an increase of the m.p. and a decrease of the T_N. In contrast, the comparative study with Dimim[FeX₄] (X = Cl and Br) compounds (Dimim: 1,3-dimethylimidazolium) shows a lower T_N in the chloride compound, Edimim[FeCl₄], whereas it is higher for the bromide, Edimim[FeBr₄]. This fact is attributed to the spin delocalization of iron atoms in [FeBr₄]^– and discards the hypothesis that a bigger imidazolium ion size causes a weaker magnetic coupling in paramagnetic ionic liquids based on tetrahaloferrate anions and imidazolium cations with 3D magnetic ordering in its solid state. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Product Details of 92507-97-6).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 92507-97-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Ionic Liquid-H₂O Interface: A New Platform for the Synthesis of Highly Crystalline and Molecular Sieving Covalent Organic Framework Membranes was written by Gao, Shuaiqi;Li, Zhiyong;Yang, Yingying;Wang, Zhenzhen;Wang, Yanlei;Luo, Shuangjiang;Yao, Kaisheng;Qiu, Jikuan;Wang, Huiyong;Cao, Li;Lai, Zhiping;Wang, Jianji. And the article was included in ACS Applied Materials & Interfaces in 2021.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Covalent organic frameworks (COFs) are highly porous crystalline polymers with uniform pores and large surface areas. Combined with their modular design principle and excellent properties, COFs are an ideal candidate for separation membranes. Liquid-liquid interfacial polymerization is a well-known approach to synthesize membranes by reacting two monomers at the interface. However, volatile organic solvents are usually used, which may disturb the liquid-liquid interface and affect the COF membrane crystallinity due to solvent evaporation Simultaneously, the domain size of the organic solvent-water interface, named the reaction zone, can hardly be regulated, and the diffusion control of monomers for favorable crystallinity is only achieved in the water phase. These drawbacks may limit the widespread applications of liquid-liquid interfacial polymerization to synthesize diverse COF membranes with different functionalities. Here, we report a facile strategy to synthesize a series of imine-linked freestanding COF membranes with different thicknesses and morphologies at tunable ionic liquid (IL)-H₂O interfaces. Due to the H-bonding of the catalysts with amine monomers and the high viscosity of the ILs, the diffusion of the monomers was simultaneously controlled in water and in ILs. This resulted in the exceptionally high crystallinity of freestanding COF membranes with a Brunauer-Emmett-Teller (BET) surface area up to 4.3 times of that synthesized at a dichloromethane-H₂O interface. By varying the alkyl chain length of cations in the ILs, the interfacial region size and interfacial tension could be regulated to further improve the crystallinity of the COF membranes. As a result, the as-fabricated COF membranes exhibited ultrahigh permeance toward water and organic solvents and excellent selective rejection of dyes. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and evaluation of solid supersaturable self-nanoemulsifying drug delivery system of candesartan cilexetil was written by Albaidhani, Safa F.;Hussein, Ahmed A.. And the article was included in Journal of Pharmaceutical Sciences and Research in 2019.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Solubility problem of many effective pharmaceutical mols. is still one of the major challenges in the formulation of these mols. Candesartan cilexetil (CC) is angiotensin II receptor antagonist and has very low water solubility and as a result of that low and variable bioavailability was produced. Supersaturable solid self- emulsifying drug delivery system (S-SSEDDS) showed a promising result in overcome solubility problem of many drug mols. with significant improvement in in-vivo bioavailability of drug mols. CC was prepared as S-SSEDDS by using novel combination of two surfactants (tween 80 and cremophore EL) and tetraglycol as cosurfactant, in addition to use of triacetin as oil and solidify using different adsorbents (Avicel PH101, Avicel PH102, Aerosil and dibasic calcium phosphate), after that a suitable precipitation inhibitor was used (HPMC K100). Different tests were performed to confirm the stability of the final product which includes; measurement of micrometric properties of the resultant powder, in-vitro drug release, SPM, FTIR, X-ray powder diffraction, DSC and in-vivo plasma level measurement. The results suggest that preparation of CC. as S-SSEDDS is a promising technique for oral delivery of CC. in order to improve its bioavailability. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structures and solution spectroscopy of lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Eichen, Yoav;Speiser, Shammai. And the article was included in Journal of Molecular Structure in 2009.Category: imidazoles-derivatives This article mentions the following:

Lophine (2,4,5-triphenylimidazole) derivatives were synthesized and their physicochem. properties were determined Spectroscopic and fluorescence behavior of lophine derivatives in methanol at different pH and various solvents were presented. The observed spectroscopic features in the solution are determined by specific interactions of the NH hydrogen. These kinds of interactions are manifested both in the solid state and in solution The crystal and mol. structures of lophine derivatives with different solvents of crystallization are presented and discussed. In all solvates the solvent mols. link host mols. through hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Syntheses of formamidines and benzimidazoles was written by Mathias, L. J.;Overberger, C. G.. And the article was included in Synthetic Communications in 1975.SDS of cas: 58442-17-4 This article mentions the following:

The benzimidazoles I (R = 5(6)-Cl, 5(6)-Me, 5(6)-CO2H, 5(6)-benzimidazol-5(6)-yl) were prepared by cyclization of 4-RC6H3(NH2)2-1,2 with HCO2H in the presence of HCl and a strong acid resin. RNHCH:NR (R = p-O2NC6H4, p-H2NC6H4, 2-thiazolyl, 2-pyridyl) and I (R = 5(6)-Me, 4(7)-Me, 5(6)-NO2, 5(6)-COMe, 5(6)-CHO, 5(6)-Cl) were prepared by treating RNH2 or RC6H4(NH2)2-1,2 with Cl2CHOMe containing (Me3C)3N. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4SDS of cas: 58442-17-4).

1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 58442-17-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

One-step radiation synthesis of novel star-shaped polymeric ionic liquid-POSS gel electrolytes with high ionic conductivity and mechanical properties for supercapacitor was written by Shi, Mengni;Lin, Tingrui;Wang, Yue;Hu, Yang;Peng, Jing;Li, Jiuqiang;Zhai, Maolin. And the article was included in Journal of Materials Science in 2020.Synthetic Route of C9H15F6N2P This article mentions the following:

Polymeric ionic liquids (PILs) not only have the unique properties of ionic liquid, but also possess diverse mech. properties of polymers. Due to their safety and conductivity, PILs-based gel polymer electrolytes (GPEs) are the promising candidates for the design of the devices. Here, we reported a facile approach to synthesize novel star-shaped GPE (named PIL-POSS-Li GPE) based on 1-vinyl-3-butylimidazolium hexafluorophosphate ionic liquid, octavinyl polyhedral oligomeric silsesquioxane (POSS) and LiPF6 solution in one step via gamma-ray radiation. Compared with PIL-Li GPE without POSS, the incorporation of POSS into the PIL-Li GPE can improve properties of PIL-POSS-Li GPE due to the formation of a star-shaped structure, and the as-prepared PIL-POSS-Li GPE showed excellent compressive strength of 1617 kPa, high fracture compression stain of 79% and high ionic conductivity of 3.88 mS cm^-1 at 25掳C. What is more, the PIL-POSS-Li supercapacitor (SC) showed better electrochem. performance than PIL-Li SC. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Synthetic Route of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem