Month: February 2023

Ionic-liquid-modified CMK-3 as a support for the immobilization of molybdate ions (MoO₄^2-): Heterogeneous nanocatalyst for selective oxidation of sulfides and benzylic alcohols was written by Hosseini-Eshbala, Fereshteh;Sedrpoushan, Alireza;Breit, Bernhard;Mohanazadeh, Farajollah;Veisi, Hojat. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2020.Computed Properties of C11H20N2 This article mentions the following:

A nanometric carbon CMK-3 modified with octylimidazolium ionic liquid (OctIm) and MoO₄^2- as a new hybrid catalyst was synthesized. The study is the first to report a successful immobilization of MoO₄^2- on the CMK-3/OctIm as a hybrid nanocatalyst. A variety of anal. methods were utilized to determine the properties of the structure and morphol. of the synthesized nanocatalyst [CMK-3/OctIm/ MoO₄^2-]. The anal. techniques were transmission electron microscopy (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma (ICP), X-ray diffraction (XRD), N₂ isotherms (BET), IR spectroscopy and thermogravimetric anal. (TGA). CMK-3/OctIm/ MoO₄^2- hybrid catalyst demonstrated a considerable catalytic activity. It is a recyclable nanocatalyst that is utilized to chemoselectively oxidize different types of sulfides RSR¹ (R = Me, Ph, prop-2-en-1-yl, etc.; R¹ = Me, Ph, cyanomethyl, etc.) and thianthrene to the corresponding sulfoxides RS(O)R¹ and thianthrene,5,10-dioxide and benzylic alcs. R²CH₂OH (R² = Ph, 3,4,5-trimethoxyphenyl, 3-chlorophenyl, etc.) to aldehydes R²CHO using the green oxidant, hydrogen peroxide (H₂O₂) in high-yields. With a little leaching and variation in activity, it is possible to recover and reuse the catalyst frequently. A combination of molybdate anion and the CMK-3 order mesoporous carbon resulted in an improvement in the performance of catalysis and ease of separation for the reaction procedure. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis, and docking studies of telmisartan analogs for the treatment of metabolic syndrome was written by Mizuno, Cassia S.;Chittiboyina, Amar G.;Patny, Akshay;Kurtz, Theodore W.;Pershadsingh, Harrihar A.;Speth, Robert C.;Karamyan, Vardan T.;Avery, Mitchell A.. And the article was included in Medicinal Chemistry Research in 2009.Recommanded Product: 4887-83-6 This article mentions the following:

In our early studies, telmisartan was found to be a moderate peroxisome proliferator-activated receptor (PPAR) gamma activator in the human PPARγ-GAL-4 cell-based transactivation assay. Thus, novel analogs of telmisartan were designed, synthesized, and evaluated in the AT₁ receptor binding assay and PPAR gamma transactivation assay. A total of 11 compounds were designed based on docking in both AT₁ receptor model and PPAR gamma active pocket and synthesized. Introduction of an addnl. acidic group at the para position of the distal Ph ring of telmisartan decreased affinity towards AT₁ receptor and PPARγ activity. In the present study, the mol. with best results was I, with weak PPARγ activity (8% of maximum PPARγ activation achieved by full agonist rosiglitazone at 10 μM) and good binding affinity (K_i = 650 ± 139 nM) towards the AT₁ receptor. Docking of I into AT₁ receptor model and PPAR gamma showed very similar interactions with the receptors as AT₁ antagonist telmisartan and PPAR gamma agonist rosiglitazone. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Recommanded Product: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Microstructure and Tribological Properties of Lamellar Liquid Crystals Formed by Ionic Liquids as Cosurfactants was written by Chen, Liping;Ge, Lingling;Fan, Lei;Guo, Rong. And the article was included in Langmuir in 2019.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

Lamellar liquid crystals (LLCs) have been shown to have lubrication properties in many documents due to their bilayer structure. Ionic liquids are often used as additive or surfactant in LLCs. However, ionic liquids used as cosurfactants, which lead to a transition from the hexagonal liquid crystals to LLCs, are relatively rare. Herein, the microstructure of Triton X-100/C_nmimNTf₂/H₂O LLCs formed by using 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ionic liquid (C_nmimNTf₂, n = 8, 12, 16) as cosurfactant has been determined by polarized light microscopy, small angle X-ray scattering, and ²H NMR technique, and their rheol. and tribol. properties were investigated. These LLCs show good friction-reducing and antiwear performances. The correlation between the microstructure of the LLCs and their lubricating mechanism is established. The increase of the concentration of C_nmimNTf₂ and the length of alkyl chain in the LLCs can lead to an obvious reduction in friction coefficients and wear volumes, which are attributed to the higher order of amphiphilic mols., the thickness of the amphiphilic bilayer, and the smaller cross-sectional area of the polar head group at the hydrophilic and hydrophobic interfaces. The protective film formed by the phys. adsorption of ionic liquid LLCs on the surface of friction disk pair and the tribochem. reaction has effectively promoted the lubrication effect. The good lubricating property and antiwear capability indicate their promising and potential applications in water lubrication and biol. lubrication. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of Alkyl Chain Length on Derived Thermodynamic Properties of 1-Alkyl-3-methylimidizolium Chloride Ionic Liquids and Their Mixtures with Ethanol was written by McCorkill, Mary E.;Dickmann, James S.;Kiran, Erdogan. And the article was included in Industrial & Engineering Chemistry Research in 2019.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Densities of the ionic liquids [C₂C₁i.m.]Cl, [C₃C₁i.m.]Cl, [C₄C₁i.m.]Cl, and [C₆C₁i.m.]Cl and their mixtures with EtOH were determined up to 40 MPa and 398 K. D. was modeled as a function of temperature, pressure, and composition using the Sanchez-Lacombe equation of state. Using the model, derived thermodn. properties, isothermal compressibility, isobaric expansivity, and internal pressure, were calculated This allowed for the estimation of the Hildebrand solubility parameters of these ionic liquids (ILs). Internal pressure was found to go through a maximum at low concentrations of ionic liquid in the case of [C₃C₁i.m.]Cl, [C₄C₁i.m.]Cl, and [C₆C₁i.m.]Cl. These observations were interpreted in terms of a significant effect of the alkyl chain length on the interactions between the IL and the cosolvent, EtOH. It is speculated that this is in part due to possible clustering between (Cl^–) and EtOH. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrogen bonds of the imidazolium rings of ionic liquids with DMSO studied by NMR, soft X-ray spectroscopy, and SANS was written by Takamuku, Toshiyuki;Tokuda, Takumi;Uchida, Takahiro;Sonoda, Kazuya;Marekha, Bogdan A.;Idrissi, Abdenacer;Takahashi, Osamu;Horikawa, Yuka;Matsumura, Junya;Tokushima, Takashi;Sakurai, Hiroyuki;Kawano, Masahiro;Sadakane, Koichiro;Iwase, Hiroki. And the article was included in Physical Chemistry Chemical Physics in 2018.Category: imidazoles-derivatives This article mentions the following:

The hydrogen bonds of the imidazolium-ring H atoms of ionic liquids (ILs), 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amides ([C_nmim][TFSA], n = 2 to 12 where n represents the alkyl chain length), with the O atom of DMSO (DMSO) have been elucidated using ¹H, ¹³C, and ¹⁵N NMR spectroscopy and soft X-ray absorption and emission spectroscopy (XAS and XES). D. functional theory (DFT) calculations have been performed on an isolated DMSO mol. and two cluster models of [C_nmim]⁺-DMSO by hydrogen bonding to interpret the XES spectra for the [C_nmim][TFSA]-DMSO solutions The ¹H and ¹³C NMR chem. shifts of the imidazolium ring showed that deshielding of the ring H and C atoms is moderate as the DMSO mole fraction x_DMSO increases to ∼0.8; however, it becomes more significant with further increase of x_DMSO. This finding suggests that the hydrogen bonds of the three ring H atoms with the DMSO O atoms are saturated in solutions with x_DMSO increased to ∼0.8. The ¹H and ¹³C chem. shifts of the alkyl chains revealed that the electron densities of the chain H and C atoms gradually decrease with increasing x_DMSO, except for the N¹-bound carbon atom C⁷ of the chain. The ¹⁵N NMR chem. shifts showed that the imidazolium-ring N¹ atom which is bound to the alkyl chain is shielded with increasing x_DMSO in the range from 0 to 0.8 and is then deshielded with further increase of x_DMSO. In contrast, the imidazolium ring N³ atom is simply deshielded with increasing x_DMSO. Thus, the electron densities of the alkyl chain may be condensed at the C⁷ and N¹ atoms of [C_nmim]⁺ by the hydrogen bonding of the ring H atoms with DMSO. The hydrogen bonding of DMSO with the ring results in low-energy shifts of the XES peaks of the O K-edge of DMSO. Small-angle neutron scattering experiments showed that [C_nmim][TFSA] and DMSO are homogeneously mixed with each other on the mesoscopic scale. This results from the strong hydrogen bonds of DMSO with the imidazolium-ring H atoms. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Category: imidazoles-derivatives).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CO₂/N₂ Triggered Switchable Surfactants with Imidazole Group was written by Chai, Mingfeng;Zheng, Zhibo;Bao, Lei;Qiao, Weihong. And the article was included in Journal of Surfactants and Detergents in 2014.COA of Formula: C11H20N2 This article mentions the following:

In order to overcome the hydrolysis of 2-alkyl-1-hydroxyethyl imidazoline and its unsatisfactory emulsification-demulsification switchability to water-alkane, the long-chain N-alkylimidazole compounds were synthesized by n-octyl bromide, n-decyl bromide, n-dodecyl bromide, n-tetradecyl bromide and n-hexadecyl bromide with imidazole, resp. and characterized by MS, ¹H NMR and FTIR. The long-chain N-alkylimidazole compounds can be reversibly transformed into charged surfactants by exposure to CO₂. Surface tension values indicated that N-alkylimidazolium bicarbonates had excellent surface activity compared with corresponding conventional surfactants with a lower γ_CMC. The surface behaviors of the five surfactants can be illustrated by A_min. Five conductivity cycles by bubbling CO₂ and N₂ alternately indicated that these surfactants could be switched by CO₂ reversibly and repeatedly. Emulsions were repeatedly stabilized for five cycles by N-alkylimidazolium bicarbonate and broken by bubbling N₂ through the solutions to reverses the reaction, releasing CO₂. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7COA of Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity was written by Hallett, Andrew J.;Placet, Emeline;Prieux, Roxane;McCafferty, Danielle;Platts, James A.;Lloyd, David;Isaacs, Marc;Hayes, Anthony J.;Coles, Simon J.;Pitak, Mateusz B.;Marchant, Sarah;Marriott, Stephen N.;Allemann, Rudolf K.;Dervisi, Athanasia;Fallis, Ian A.. And the article was included in Dalton Transactions in 2018.Related Products of 21252-69-7 This article mentions the following:

A systematic study of the cellular uptake of emissive complexes as a function of their lipophilicity is presented. Here a series of amphiphilic rhenium fac-tricarbonyl bisimine complexes bearing axial substituted imidazole or thiazole ligands, [Re(bpy)(CO)₃(ImC_nH_m)]⁺ {n = 1 m = 3 (1⁺), n = 4 m = 9 (2⁺), n = 8 m = 17 (3⁺), n = 12 m = 25 (4⁺), n = 16 m = 33 (5⁺), n = 2 m = 3 (6⁺); bpy = 2,2′-bipyridine, Im = imidazole} and [Re(bpy)(CO)₃(L)]⁺ {L = 1-mesitylimidazole, ImMes (7⁺), 4,5-dimethylthiazole, dmt (8⁺) and 4-methyl-5-thiazole-ethanol, mte (9⁺)} is reported. The X-ray crystal structures of 2⁺, 8⁺ and 9⁺ confirm the geometry and expected distribution of ligands and indicated that the plane of the imidazole/thiazole ring is approx. parallel to the long axis of the bipy ligand. Luminescence studies revealed excellent properties for their use in cell imaging with visible excitation and broad emission profiles. Their uptake in two distinct species has been examined by fluorescence imaging of the diplomonad fish parasite Spironucleus vortens (S. vortens) and rod-shaped yeast Schizosaccharomyces pombe (Schiz. pombe) as a function of their lipophilicity. The uptake of the complexes was highest for the more lipophilic 2⁺-5⁺ in both S. vortens and Schiz. pombe in which the long alkyl chain aids in crossing bilipid membranes. However, the increased lipophilicity of longer chains also resulted in greater toxicity. Localization over the whole cell varied with differing alkyl chain lengths with complex 2⁺ preferentially locating to the nucleus of S. vortens, 3⁺ showing enhanced nuclear partitioning in Schiz. pombe, and 4⁺ for the remaining cell wall bound in the case of S. vortens. Interestingly, complexes of intermediate lipophilicity such as 7⁺ and 8⁺ showed reasonable uptake, proved to be non-toxic, and were capable of crossing exterior cell walls and localising in the organelles of the cells. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Related Products of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of the rat liver S-9 fraction on the mutagenicity of azathioprine in the Salmonella/mammalian microsome assay was written by Nepomnaschy, I.;Sommer, S. E.;Nagel, R.. And the article was included in Experientia in 1984.Recommanded Product: 3034-41-1 This article mentions the following:

Azathioprine (I) [446-86-6] is a direct acting mutagen in S. typhimurium TA 100 and 1535. The addition of rat liver S-9 fraction with or without cofactors, or GSH  [70-18-8], decreased the mutagenicity of I in TA 100 and increased in TA 1535, indicating the effect of SH groups. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation, structure, and properties of chitosan/cellulose/multiwalled carbon nanotube composite membranes and fibers was written by Xiao, Wenjun;Wu, Tinghua;Peng, Jiajian;Bai, Ying;Li, Jiayun;Lai, Guoqiao;Wu, Ying;Dai, Lizong. And the article was included in Journal of Applied Polymer Science in 2013.Electric Literature of C4H7ClN2 This article mentions the following:

Binary ionic liquids (ILs), 1-butyl-3-methylimidazolium chloride and 1-H-3-methylimidazolium chloride, were developed to dissolve chitosan and cellulose and disperse multi-walled carbon nanotubes (MWCNTs). The resulting mixed paste could be used to prepare chitosan/cellulose/MWCNT composite membranes and fibers. Fourier transform IR spectroscopy, wide-angle x-ray diffraction, thermogravimetric anal., SEM, tensile testing, and conductivity measurements were used to evaluate the structure and properties of the composite materials and the effect of the incorporation of MWCNTs at various loadings. The characterization results indicate that the incorporation of MWCNTs improved the comprehensive performances of the composite materials, and the best loading of MWCNTs was 4 wt %. This IL dissolution method is a green and feasible method for preparing chitosan/cellulose/MWCNT composite membranes and fibers and will provide beneficial references for the preparation of similar materials. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2012. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Microwave-Accelerated Cross-Dehydrogenative Coupling of Quinoxalin-2(1H)-ones with Alkanes under Transition-Metal-Free Conditions was written by Wang, Min;Zhang, Zhongyi;Xiong, Chunxia;Sun, Peipei;Zhou, Chao. And the article was included in ChemistrySelect in 2022.Synthetic Route of C8H8N2 This article mentions the following:

With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross-dehydrogenative alkylation reaction of quinoxalin-2(1H)-ones and other N-heteroarenes was achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin-2(1H)-ones and other alkylated N-heteroarenes in good-to-excellent yields. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Synthetic Route of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem