Month: February 2023

Corrosion inhibition of carbon steel in acidic environment by imidazolium ionic liquids containing vinyl-hexafluorophosphate as anion was written by Likhanova, Natalya V.;Olivares-Xometl, Octavio;Guzman-Lucero, Diego;Dominguez-Aguilar, Marco A.;Nava, Noel;Corrales-Luna, Monica;Mendoza, M. Consuelo. And the article was included in International Journal of Electrochemical Science in 2011.Formula: C9H15F6N2P This article mentions the following:

Five imidazolium-type ionic liquids, containing both N1-unsaturated chain and N3-long alkyl saturated chain as cations and hexafluorophosphate as anion (VImC_xPF₆, x = 4, 8, 12, 18 and 22), were evaluated as corrosion inhibitors for carbon steel SAE 1018 in 1.0 M H₂SO₄ solution The compounds presented relatively high inhibition efficiencies (∼81-96%) at 100 ppm as confirmed by weight loss tests and polarization curves. Synthesized inhibitors obeyed Langmuir adsorption and behaved as mixed type inhibitors, displaying phys. and chem. adsorption depending on the length of the carbon chain link to N3. Mossbauer anal. of corrosion products mainly determined the presence szomolnokite (FeSO₄.H₂O), whose content increased with aliphatic chain length suggesting that corrosion inhibition occurred by iron sulfate formation. The most effective compound (VImC₁₂PF₆) was the only that displayed the presence of alpha iron, iron hydroxide and rozenite (FeSO₄.4H₂O) as corrosion products. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Formula: C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gas-Phase Studies of Substrates for the DNA Mismatch Repair Enzyme MutY was written by Michelson, Anna Zhachkina;Rozenberg, Aleksandr;Tian, Yuan;Sun, Xuejun;Davis, Julianne;Francis, Anthony W.;O’Shea, Valerie L.;Halasyam, Mohan;Manlove, Amelia H.;David, Sheila S.;Lee, Jeehiun K.. And the article was included in Journal of the American Chemical Society in 2012.Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

The gas-phase thermochem. properties (tautomeric energies, acidity, and proton affinity) have been measured and calculated for adenine and six adenine analogs that were designed to test features of the catalytic mechanism used by the adenine glycosylase MutY. The gas-phase intrinsic properties are correlated to possible excision mechanisms and MutY excision rates to gain insight into the MutY mechanism. The data support a mechanism involving protonation at N7 and hydrogen bonding to N3 of adenine. We also explored the acid-catalyzed (non-enzymic) depurination of these substrates, which appears to follow a different mechanism than that employed by MutY, which we elucidate using calculations In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Physicochemical properties of polyaniline-ionic liquid mixtures and their application in dye-sensitized solar cells was written by Attri, Pankaj;Park, Dae Hoon;Lee, Seung-Hyun;Kim, Young Sun;Kim, Young Beom;Kwon, Gi-Chung;Choi, Wooyeol;Jun, Yongseok;Lee, Hae-Seok;Choi, Eun Ha;Kim, In Tae. And the article was included in Science of Advanced Materials in 2015.Related Products of 35487-17-3 This article mentions the following:

In this study, we investigated the interactions between the ionic liquids (ILs) of ammonium and imidazolium families and polyaniline-emeraldine base [PANI (EB)]. PANI (EB) is one of the most studied conducting polymers owing to its applications in electronics, optical devices, sensors, etc. However, there is a massive scope of improvement in this area. In order to increase the utility of PANI (EB), we studied the interactions between PANI (EB) and ILs by using various techniques. Further, we studied the conductivity, morphol., and roughness of PANI (EB)-IL mixtures We observed that ammonium- and imidazolium-family ILs have the potential to interact with PANI (EB). However, after the interactions, the ammonium-family IL-PANI (EB) mixtures showed more conductivity than the imidazolium-family IL-PANI (EB) mixtures We also determined the strength of hydrogen bonding between ILs and PANI (EB) from semiempirical calculations carried out using HyperChem 7. Finally, we demonstrated that PANI (EB)-IL additives can be used as electrolytes in dye-sensitized solar cells. This study provides an insight into the combined effect of a polymer [PANI (EB)] and ILs, and this insight may generate many theor. and exptl. opportunities. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Related Products of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Related Products of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Continuous Flow Hydroformylation of Alkenes in Supercritical Fluid-Ionic Liquid Biphasic Systems was written by Webb, Paul B.;Sellin, Murielle F.;Kunene, Thulani E.;Williamson, Sylvia;Slawin, Alexandra M. Z.;Cole-Hamilton, David J.. And the article was included in Journal of the American Chemical Society in 2003.Electric Literature of C7H13ClN2 This article mentions the following:

A process for the hydroformylation of relatively low volatility alkenes (demonstrated for 1-dodecene) in a continuous flow system is described. The catalyst is dissolved in an ionic liquid while the substrate and gaseous reagents are transported into the reactor dissolved in supercritical CO₂, which simultaneously acts as a transport vector for aldehyde products. Decompression of the fluid mixture downstream yields products which are free of both reaction solvent and catalyst. The use of rhodium complexes of triaryl phosphites as catalysts leads to ligand degradation through reaction of the ionic liquid with water and subsequent attack of the released HF on the phosphite. Sodium salts of sulfonated phosphines are insufficiently soluble in the ionic liquids to obtain acceptable rates, but replacing the sodium by a cation similar to that derived from the ionic liquid, allows good solubility and activity to be obtained. The nature of the ionic liquid is important in achieving high rates, with 1-alkyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amides giving the best activity if the alkyl chain is at least C₈. Catalyst turnover frequency as high as 500 h^-1 was observed, with the better rate at higher substrate flow rate. Rhodium leaching into the product stream can be as low as 0.012 ppm, except at low partial pressures of CO/H₂, when it is significantly higher. Oxygen impurities in the CO₂ feed can lead to oxidation of the phosphine giving higher rates, lower selectivity to the linear aldehyde, increased alkene isomerization, and greater leaching of rhodium. However, under certain process conditions, the supercritical fluid-ionic liquid (SCF-IL) system can be operated continuously for several weeks without any visible sign of catalyst degradation Comparisons with com. hydroformylation processes are provided. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors was written by Li, Na;Yang, Hong;Liu, Ke;Zhou, Liwei;Huang, Yuting;Cao, Danyan;Li, Yanlian;Sun, Yaoliang;Yu, Aisong;Du, Zhiyan;Yu, Feng;Zhang, Ying;Wang, Bingyang;Geng, Meiyu;Li, Jian;Xiong, Bing;Xu, Shilin;Huang, Xun;Liu, Tongchao. And the article was included in Journal of Medicinal Chemistry in 2022.Safety of 4-Bromo-1-methylimidazole This article mentions the following:

A series of NSD2-PWWP1 inhibitors I (R = 4-cyanophenyl, 4-cyanonaphthalen-1-yl, 8-cyanoquinolin-5-yl, etc.; R¹ = H, OMe, F, Cl, CF₃; R² = H, Me, OMe; R³ = aminomethyl, CHO, 4-aminopiperidin-1-yl, etc.), and further structure-based optimization resulted in a potent inhibitor compound I (R = 4-cyanonaphthalen-1-yl; R¹ = R² = Me; R³ = 4-aminopiperidin-1-yl) (II), that has high selectivity toward the NSD2-PWWP1 domain were reported. The detailed biol. evaluation revealed that compound II can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. The current discovery will provide a useful chem. probe to the future research in understanding the specific regulation mode of NSD2 by PWWP1 recognition and pave the way to develop potential drugs targeting NSD2 protein. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Safety of 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A novel strategy for fabricating highly stretchable and highly conductive photoluminescent ionogels via an in situ self-catalytic cross-linking reaction in ionic liquids was written by Hao, Shuai;Zhang, Jianxin;Yang, Xuemeng;Li, Tianci;Song, Hongzan. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021.Reference of 915358-85-9 This article mentions the following:

We report a new method to fabricate highly stretchable and highly conductive fluorescent ionogels via self-catalytic crosslinking of poly(ionic liquid (IL))-based copolymers containing epoxy groups in ILs without adding any conventional crosslinkers and chromophores. Here, the ILs serve as a solvent, electrolyte, and catalyst, while the product of the ring-opening reactions acts as crosslinking junctions. The results reveal that these systems are typical autocatalytic systems and that the IL anion type significantly influences the curing reaction kinetics. These ionogels exhibit excellent stretchability (>1200%), high ionic conductivity (>1 mS cm^-1), and good temperature tolerance (-40 to 200°C). Surprisingly, the special crosslinking structures make the ionogels show typical aggregation-induced emission behavior and possess tunable photoluminescence properties. Moreover, ionogel-based strain sensors exhibit fast response speed, excellent temperature tolerance and stability, and can monitor various human motions. Therefore, our study provides a facile method to utilize several distinct properties of ILs and PILs for designing multifunctional ionogels that serve as flexible conductive and fluorescent materials. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Reference of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic ionic liquids: A highly efficient catalyst for synthesis of cyclic carbonate from carbon dioxide and epoxides was written by Xiao, Linfei;Su, Dan;Yue, Chengtao;Wu, Wei. And the article was included in Journal of CO2 Utilization in 2014.Formula: C4H7ClN2 This article mentions the following:

An efficient, inexpensive, easily prepared and sustainable catalytic system of protic ionic liquids was developed for cycloaddition of CO2 and epoxides to produce cyclic carbonates without using any co-catalyst and organic solvent. The effects of the acidity and structure of protic ionic liquid on the catalytic performance were investigated and the various reaction conditions were optimized. Notably, this catalyst was used for five times at least without appreciable loss of catalytic activity and applied for various epoxide for synthesis of corresponding cyclic carbonate in high selectivity and yield. Addnl., a mechanism for the synergistic effects of cation and anion in protic ionic liquids was also proposed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Formula: C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvent-free synthesis of tris(4-hydroxybutyl acrylate) phosphate in the presence of 1-methylimidazole was written by Ilia, Gheorghe;Macarie, Lavinia;Plesu, Nicoleta;Iliescu, Smaranda;Popa, Adriana. And the article was included in Journal of the Iranian Chemical Society in 2018.HPLC of Formula: 35487-17-3 This article mentions the following:

In this paper, we present the synthesis of tris(4-hydroxybutyl acrylate) phosphate using 1-methylimidazole as acid scavenger for hydrochloric acid byproduct, when an ionic liquid is formed. The synthesis was performed in the absence of any organic solvent. The yield is 83% for ester. The phosphate was characterized by ¹H-³¹P NMR and FTIR. The obtained phosphate is appropriate monomer for UV curing in the presence of photoinitiator. The obtained polymer was characterized by thermal anal. and LOI. The results showed good thermal stability and flame retardancy of UV-cured polymer. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids was written by Stagel, Kristof;Szpecht, Andrea;Zielinski, Dawid;Smiglak, Marcin;Schnuerch, Michael;Bica-Schroeder, Katharina. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

A novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf₂^–) anion. The simple yet fast two-step synthetic route, which involved the formation of different alkyl bistriflimides (RNTf₂), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R) length and the broad range of the applicable nucleophiles offer considerable flexibility to the synthetic protocol. The quaternization could be performed under solvent-free conditions; moreover, the homogeneous nature of these reactions allowed the application of modern continuous-flow technologies. Given these advantages, the methodol. could afford not just a fast and efficient alternative for the conventional synthesis of such compounds with reduced waste water production but their negligible halide content might provided a significantly broader application range of the IL products, especially for the field of materials science. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors was written by Gandini, Annachiara;Bartolini, Manuela;Tedesco, Daniele;Martinez-Gonzalez, Loreto;Roca, Carlos;Campillo, Nuria E.;Zaldivar-Diez, Josefa;Perez, Concepcion;Zuccheri, Giampaolo;Miti, Andrea;Feoli, Alessandra;Castellano, Sabrina;Petralla, Sabrina;Monti, Barbara;Rossi, Martina;Moda, Fabio;Legname, Giuseppe;Martinez, Ana;Bolognesi, Maria Laura. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 3012-80-4 This article mentions the following:

Several findings propose the altered tau protein network as an important target for Alzheimer’s disease (AD). Particularly, two points of pharmacol. intervention can be envisaged: inhibition of phosphorylating tau kinase GSK-3β and tau aggregation process. On the basis of this consideration and on the authors’ interest in multitarget paradigms in AD, the authors report on the discovery of 2,4-thiazolidinedione derivatives endowed with such a profile. 28 and 30 displayed micromolar IC₅₀ values toward GSK-3β, together with the capacity of inhibiting AcPHF6 aggregation of 60% and 80% at 10 μM, resp. In addition, they showed PAMPA-BBB permeability, together with a suitable cellular safety profile. 30 also displayed inhibition of both K18 and full-length tau aggregations. Finally, both compounds were able to improve cell viability in an okadaic acid-induced neurodegeneration cell model. To the best of the authors’ knowledge, 28 and 30 are the first balanced, nontoxic, dual-acting compounds hitting tau cascade at two different hubs. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem