Month: February 2023

Electrochemical reduction of bifunctional organic compounds. XI. Substituted N-methylnitroimidazoles was written by Kargin, Yu. M.;Latypova, V. Z.;Fassakhov, R. Kh.;Arkhipov, A. I.;Eneikina, T. A.;Sharnin, G. P.. And the article was included in Zhurnal Obshchei Khimii in 1979.Synthetic Route of C4H5N3O2 This article mentions the following:

The mechanism was studied of the electrochem. reduction of nitro- and halo-substituted N-methylimidazoles where the substituents are NO₂, Cl, Br, H, and NHPh. The process begins with the reverse transfer of an electron to the mol. to form anion radicals with different degrees of stability. The rate of anionic elimination of Br^– from positions 2 and 5 in the anion radicals of 1-methyl-2(5)-bromo-4-nitroimidazole (k = 8.2 ± 0.5 and 12.1 ± 0.5 s^-1, resp.) was evaluated. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Synthetic Route of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4,7-Diarylbenzo[c][1,2,5]thiadiazoles as fluorophores and visible light organophotocatalysts was written by Taylor, Dominic;Malcomson, Thomas;Zhakeyev, Adilet;Cheng, Shengxian;Rosair, Georgina M.;Marques-Hueso, Jose;Xu, Zhengtao;Paterson, Martin J.;Dalgarno, Scott J.;Vilela, Filipe. And the article was included in Organic Chemistry Frontiers in 2022.Related Products of 1632-83-3 This article mentions the following:

The synthesis, characterization, and application of a library of 26 D-A compounds I (R = Ph, 4-hydroxyphenyl, thiophen-2-yl, etc.) based on the BTZ group were described. By varying the donor groups while keeping the BTZ acceptor group the same, and the photocatalyst’s optoelectronic and photophys. properties can be systematically modified. These photocatalysts were then validated using a Minisci-type decarboxylative alkylation of electron deficient heteroarenes (such as lepidine, 2-methylquinoline, isoquinoline, etc.) as a test reaction under both batch and continuous flow conditions. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Related Products of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Related Products of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient protocol for the aromatic compounds nitration catalyzed by magnetically recyclable core/shell nanocomposite was written by Maleki, Ali;Aghaei, Morteza;Paydar, Reza. And the article was included in Journal of the Iranian Chemical Society in 2017.HPLC of Formula: 3034-41-1 This article mentions the following:

An efficient protocol for the nitration of aromatic compounds in the presence of a catalytic amount of sulfuric acid-functionalized silica-based magnetic core/shell nanocomposite was reported. The designed products were obtained in high yields in relatively short reaction times at room temperature under solvent-free conditions. The nanocatalyst was simply recovered from the reaction mixture by using an external magnet and efficiently reused for several times. The characterization of particle size, morphol. and elemental anal. of the nanocatalyst were provided by SEM, transmission electron microscopy and energy-dispersive X-ray spectroscopy analyses, resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1HPLC of Formula: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Activity of antitumor drugs against african trypanosomes was written by Kinnamon, Kenneth E.;Steck, Edgar A.;Rane, Dora S.. And the article was included in Antimicrobial Agents and Chemotherapy in 1979.Recommanded Product: 26832-08-6 This article mentions the following:

Of 49 compounds with antitumor properties, 6 had significant activity against Trypanosoma rhodesiense infections in mice. In order of decreasing activity these compounds were imidazole-4-carboxamide (I) [26832-08-6], inosine diglycoaldehyde (II) [23590-99-0], cis-diamminedichloroplatinum [15663-27-1], streptozotocin [18883-66-4], coralyne sulfate [38989-37-6], and 5-fluoro-2′-deoxyuridine [50-91-9]. Of these compounds, only diamminedichloroplatinum was toxic. These compounds may have therapeutic importance against Trypanosoma infections. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Protic, Aprotic, and Choline-Derived Ionic Liquids: Toward Enhancing the Accessibility of Hardwood and Softwood was written by Rigual, Victoria;Ovejero-Perez, Antonio;Rivas, Sandra;Dominguez, Juan C.;Alonso, M. Virginia;Oliet, Mercedes;Rodriguez, Francisco. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Reference of 35487-17-3 This article mentions the following:

A side-by-side comparison of softwood (pine) vs. hardwood (eucalyptus) pretreatment using 3 protic, 3 aprotic, and 3 choline-derived ionic liquids (ILs) is proposed. While the protic ionic liquid 2-hydroxyethylammonium formate leads to alkali lignin dissolution at 30°C after 1 h, the lack of interactions with the whole-cell wall limits the biomass disruption. On the contrary, the protic ionic liquid 1-methylimidazolium chloride produces a catalytic effect that extracts almost all of the hemicelluloses, and partially the lignin. Remarkable digestibilities are obtained with choline acetate ([Ch][OAc]) in eucalyptus (69%), while in pine, protic, and choline-derived ILs tested do not appear to be real “greener” alternatives to conventional ILs such as 1-ethyl-3-methylimidazolium acetate (the highest digestibility, 84%). Solid morphol. revealed a smoother surface in pine pretreated with [Mim][Cl], and confocal fluorescence microscopy was used to distinguish surface holocellulose and lignin, highlighting differences in the accessibility of hardwood vs. softwood due to the presence of surface lignin. Two-dimensional NMR spectroscopy of saccharified samples pretreated with [Ch][OAc] showed the presence of groups derived from acetate. Finally, thermogravimetric anal. and spectroscopy techniques reveal the difficulties in recovering the ionic liquid and conclude a work that describes the strengths and weaknesses of the ILs and biomasses studied. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Reference of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A simple, eco-friendly, and recyclable bi-functional acidic ionic liquid catalysts for Beckmann rearrangement was written by Kore, Rajkumar;Srivastava, Rajendra. And the article was included in Journal of Molecular Catalysis A: Chemical in 2013.Synthetic Route of C4H7ClN2 This article mentions the following:

A library of ionic liquids was prepared by varying the cations and anions. Bi-functional acidic ionic liquids were prepared by the direct combination of ionic liquids and ZnCl₂. Ionic liquids were investigated in the Beckmann rearrangements. A simple, eco-friendly, and recyclable bi-functional acidic ionic liquid based protocol for Beckmann rearrangement is developed, which is based on the fine tuning of the Broensted and the Lewis acidity of ionic liquids In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aqueous-phase, palladium-catalyzed Suzuki reactions under mild conditions was written by Cai, Yueqin;Song, Gonghua;Wu, Zhongyuan;Zhang, Jiawei. And the article was included in Green and Sustainable Chemistry in 2013.Electric Literature of C11H20N2 This article mentions the following:

A series of biaryls I [R¹ = H, 4-Me, 2-MeO, etc.; R² = H, 4-Me, 4-MeO, etc.] were prepared by Suzuki coupling of aryl halides and aryl boronic acids using ionic liquid-supported diols as phosphine-free ligands under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-methyl) propane-1,3-diol hexafluorophosphate in combination with palladium (II) salts gave the most significant and reusable catalyst. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Electric Literature of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidative degradation of chitosan by H₂O₂ in acidic ionic liquid aqueous solutions was written by Wu, Changchun;Zang, Hongjun;Li, Daqing;Zhang, Mingchuan;Yu, Jianchun;Cheng, Bowen. And the article was included in Gaofenzi Cailiao Kexue Yu Gongcheng in 2014.Name: 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

In this paper, ionic liquid 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate ([MIMBS]HSO₄) with better dissolution performance was selected. The oxidative degradation of high mol. weight chitosan was conducted with H₂O₂ in the above-mentioned ionic liquid aqueous solution, and the reaction system was homogeneous. In order to optimize the reaction conditions, the influence of dosage of ionic liquid, n (H₂O₂): n (chitosan), reaction temperature and reaction time on the degradation were studied. The mol. weight of chitosan was determined by viscosity method. The structures of original and degraded chitosan were characterized by FT-IR and XRD. The results indicate that the crystal structures of chitosan are destroyed, and the crystallinity decreases. The oxidative degradation reactions proceed more completely with increasing ionic liquid concentration At the meantime, the increased dosage of H₂O₂, enhanced reaction temperature and prolonged reaction time also promote this degradation reaction. The optimum conditions are determined as follows: the aqueous solution of 8% [MIMBS]HSO₄, n (H₂O₂): n (chitosan) = 5:1, reaction temperature equal to 80°C and reaction time equal to 3 h. Under the above reaction conditions, the yield of the regenerated chitosan is 74%, and the viscosity-average mol. weight is 21.2 × 10³. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Name: 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The Zuellig Pharma Korea Consortium Database: an on-site drug wholesales database for pharmacoepidemiological studies using real-world data was written by Jeong, Han Eol;Oh, In-Sun;Li, Junqing;Vilfeu, Erwan;Ryuu, Sang A.;Shin, Ju-Young. And the article was included in International Journal of Clinical Pharmacology and Therapeutics in 2019.Category: imidazoles-derivatives This article mentions the following:

Objective: To assess the value and representativeness of the Zuellig Pharma Korea Consortium (ZPK-C) database, which contains drug wholesales data collected in a weekly interval, for its prospective use as a data source for pharmacoepidemiol. studies. Materials and methods: Wholesales and nationwide claims data of antidiabetic and antihypertensive products were compared in 17 administrative regions using the defined daily dose per 100,000 inhabitants per day (DID) and its proportion for standardized evaluation. Results: We found regional concordance in 12 and 13 regions (out of 17) for antidiabetic and antihypertensive products, resp., of which concordance was higher in rural than metropolitan regions. Conclusion: The ZPK-C showed potential as a valuable data source for pharmacoepidemiol. research. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Category: imidazoles-derivatives).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solubility of argon, krypton and xenon in ionic liquids was written by Song, Tangqiumei;Lubben, Michael J.;Brennecke, Joan F.. And the article was included in Fluid Phase Equilibria in 2020.SDS of cas: 404001-48-5 This article mentions the following:

This work presents the results of argon, krypton and xenon solubility measurements in a series of imidazolium-based ionic liquids (ILs) with the bis(trifluoromethylsulfonyl)imide ([TFSI]^–), 2-cyanopyrrolide ([2CNPyr]^–) and hexafluorophosphate ([PF₆]^–) anions, as well as ILs with the trihexyltetradecylphosphonium ([P₆₆₆₁₄]⁺) cation paired with 2-cyanopyrrolide ([2CNPyr]^–) and 1,2,4-triazolide ([4-triaz]^–) anions. The solubility of Ar was measured at 295 K and pressures up to 9 MPa, Kr was also measured at 295 K and pressures up to 5 MPa, and Xe was measured at temperatures from 295 K to 333 K and pressures up to 0.3 MPa. Noble gases are simple nonpolar, spherical atoms with varying sizes and polarizabilities. While their separation, especially from air, is relevant because they have uses in providing inert atmospheres and in fluorescent lights, the main purpose of this study is to gain fundamental understanding of the influence of size and polarizability on gas solubility in ILs. As a result, the temperature effects on the dissolution of argon and xenon were investigated in order to determine enthalpies of dissolution The solubilities of noble gases correlate strongly with the IL molar volume, indicating the importance of entropic interactions, because free volume generally correlates with molar volume. While van der Waals interactions are the dominant forces between smaller noble gas (like Ar) and the IL, Xe has sufficiently high polarizability that both van der Waals and induced dipole-dipole interactions contribute to its dissolution In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5SDS of cas: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem