Month: February 2023

Stabilizing Au(III) in supported-ionic-liquid-phase (SILP) catalyst using CuCl₂ via a redox mechanism was written by Zhao, Jia;Yu, Yi;Xu, Xiaolong;Di, Shuxia;Wang, Bolin;Xu, Hao;Ni, Jun;Guo, Ling Ling;Pan, Zhiyan;Li, Xiaonian. And the article was included in Applied Catalysis, B: Environmental in 2017.Related Products of 79917-89-8 This article mentions the following:

High-valent Au(III) complexes have attracted much attention as catalysts in many reactions. Nevertheless Au(III) catalysts suffer from instability of the oxidized metal complexes during preparation and use. Herein, we demonstrated that Au(III) catalysts can be stabilized against reduction to metallic Au⁰ by modifying supported-ionic-liquid-phase-stabilized Au(III) catalyst with CuCl₂. It was found that the reduced Au⁰ could be re-oxidized in situ to Au³⁺ species by CuCl₂ during the reaction and further stabilized by the electron transfer from Cu to these active species. When evaluated in the acetylene hydrochlorination reaction, the Au-Cu-IL/AC catalyst displayed an excellent specific activity with the turnover frequency (TOF) as high as 168.5 h^-1 and more than 99.8% selectivity for the product, vinyl chloride (VCM). Furthermore, the Au-Cu-IL/AC catalyst demonstrated a stable catalytic performance with a negligible loss of C₂H₂ conversion after 500 h under typical industrial reaction conditions for acetylene hydrochlorination. Therefore, the findings of this work provide an efficient approach for designing stable high-valent metals for long-term operation, and also pave the way for the application of Au-Cu-IL/AC catalyst in industrial VCM production In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Related Products of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquid-regulated sulfamic acid. Chemoselective catalyst for the transesterification of β-ketoesters was written by Wang, Bo;Ming, Yang Li;Shuan, Suo Ji. And the article was included in Tetrahedron Letters in 2003.Reference of 79917-89-8 This article mentions the following:

1-Propyl-3-methylimidazolium chloride ([C₃MIm]Cl) ionic liquid and sulfamic acid (NH₂SO₃H), as a synergetic catalytic medium, were used for the transesterification of acetoacetate with alcs. of different structures. It shows the good ability for the chemoselective transesterification of β-ketoesters and maintains its catalytic activity in the reuse. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Symmetry vs. asymmetry – Enthalpic differences in imidazolium-based ionic liquids was written by Yermalayeu, Andrei V.;Varfolomeev, Mikhail A.;Verevkin, Sergey P.. And the article was included in Journal of Molecular Liquids in 2020.HPLC of Formula: 21252-69-7 This article mentions the following:

Enthalpies of ionic liquids [C_nC_nIm][X] synthesis reactions were measured with help of differential scanning calorimetry. These results in combination with quantum-chem. calculations were used for estimation of vaporization enthalpies of sym. imidazolium based ionic liquids with X = Cl, Br, and I. Vaporization enthalpies of the sym. ([C_nC_nIm][X]) series were found to be systematically lower (of 5-8 kJ mol^-1) in comparison with the corresponding asym. imidazolium-based ILs ([C_nC₁Im][X]). This energetic difference was attributed to the intensity of dispersion interactions. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7HPLC of Formula: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 3-arylmethyl-2-oxindole derivatives and their effects on neuronal cell death was written by Furuta, Kyoji;Mizuno, Yosuke;Maeda, Masahide;Koyama, Hiroko;Hirata, Yoko. And the article was included in Chemical & Pharmaceutical Bulletin in 2017.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Various 3-arylmethyl-2-oxindole derivatives were synthesized by the Knoevenagel condensation of oxindoles and aromatic aldehydes followed by palladium-mediated hydrogenation or hydride-reduction Further substituted derivatives at C-3 and/or N-1 of the oxindole skeleton were prepared from the condensation products. Their protective effect against neuronal cell death induced by oxidative stress was evaluated by lactate dehydrogenase assay. A structure-activity relationship study revealed that compounds with any of the dialkylamino, nitro or hydroxy groups on the 3-arylmethyl moieties elicit a superior potency to suppress cell death, while others were ineffective. Substitutions with less polar functional groups on the benzene or lactam ring of the oxindole skeleton pos., but not remarkably, affect the potency. In addition, the stereochem. at C-3 of the oxindole core was not a crucial factor for the neuroprotective activity of the compounds In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

C-Acylation of 5-membered N-heterocycles. I. Acylation at C-2 of imidazoles and benzimidazoles was written by Regel, Erik;Buechel, Karl Heinz. And the article was included in Justus Liebigs Annalen der Chemie in 1977.Recommanded Product: 1-Methyl-4-nitroimidazole This article mentions the following:

2-Acylimidazoles (74 compounds) were prepared by acylating imidazoles in the presence of NEt3. 2-Imidazolecarboxylates were similarly obtained with chloroformates. Similar reactions with phthaloyl chlorides gave imidazo[1,2-b]isoquinoline-5,10-diones which underwent ring cleavage to 2-imidazolyl 2-acylphenyl ketones. Benzimidazoles reacted similarly with phthaloyl chlorides. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials was written by Barrows, Robert D.;Hammill, Jared T.;Tran, Michael C.;Falade, Mofolusho O.;Rice, Amy L.;Davis, Christopher W.;Emge, Thomas J.;Rablen, Paul R.;Guy, R. Kiplin;Knapp, Spencer. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Computed Properties of C8H8N2 This article mentions the following:

The 4-(heteroarylthio)thieno[2,3-d]pyrimidine (TTP) series of antimalarials, represented by I and II, potently inhibit proliferation of the 3D7 strain of P. falciparum (EC₅₀ 70-100 nM), but suffer from oxidative metabolism The 1,1-cyclopropylidene isosteres III and IV were designed to obviate this drawback. They were prepared by a short route that featured a combined Peterson methylenation/cyclopropanation transformation of (4-methylthiazol-2-yl)(thieno[2,3-d]pyrimidin-4-yl)methanone. Isosteres III and IV possessed significantly attenuated antimalarial potency. This outcome could be rationalized based on the increased out-of-plane steric demands of the latter two. In support of this hypothesis, the relatively flat (4-methylthiazol-2-yl)(thieno[2,3-d]pyrimidin-4-yl)methanone retained some of the potency of I, even though it appeared to be a comparatively inferior mimic with respect to electronics and bond lengths and angles. Also crystallog. and computationally an apparent increase in the strength of the intramol. sulfur hole interaction of I upon protonation was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cation Alkyl Side Chain Length and Symmetry Effects on the Surface Tension of Ionic Liquids was written by Almeida, Hugo F. D.;Freire, Mara G.;Fernandes, Ana M.;Lopes-da-Silva, Jose A.;Morgado, Pedro;Shimizu, Karina;Filipe, Eduardo J. M.;Canongia Lopes, Jose N.;Santos, Luis M. N. B. F.;Coutinho, Joao A. P.. And the article was included in Langmuir in 2014.SDS of cas: 404001-48-5 This article mentions the following:

The surface tension of two series of ILs, R,R’-dialkylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([C_nC_ni.m.][NTf₂]), and R-alkyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide ([C_nC₁i.m.][NTf₂]), and their dependence on temperature (from 298 to 343 K) have been studied. For both series of ILs the surface tension decreased with an increase in the cation side alkyl chain length up to aliphatic chains no longer than hexyl, here labeled as critical alkyl chain length (CACL). For ILs with aliphatic moieties longer than CACL the surface tension displayed an almost constant value up to [C₁₂C₁₂i.m.][NTf₂] or [C₁₆C₁i.m.][NTf₂]. These constant values further converged to the surface tension of long chain n-alkanes, indicating that, for sufficiently long alkyl side chains, the surface ordering was strongly dominated by the aliphatic tails present in the IL. The enthalpies and entropies of surface were also derived and the critical temperatures were estimated from the exptl. data. The trend of the derived thermodn. properties highlights the effect of the structural organization of the IL at the surface with visible trend shifts occurring at a well-defined CACL in both sym. and asym. series of ILs. The structure of a long-alkyl side chain IL at the vacuum-liquid interface was explored using mol. dynamics simulations. For the sym. series of ILs, at the outermost polar layers, more cations pointed one of their aliphatic tails outward and the other inward, relative to the surface, than cations pointing both tails outward. The number of the former, while being the preferred conformation, exceeds the latter by around 75%. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5SDS of cas: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3 was written by Song, Xianzhou;Chen, Jianwei;Zhao, Mingkun;Zhang, Chengwei;Yu, Yang;Lonard, David M.;Chow, Dar-Chone;Palzkill, Timothy;Xu, Jianming;O’Malley, Bert W.;Wang, Jin. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2016.Product Details of 85692-37-1 This article mentions the following:

Protein-protein interactions (PPIs) play a central role in most biol. processes, and therefore represent an important class of targets for therapeutic development. However, disrupting PPIs using small-mol. inhibitors (SMIs) is challenging and often deemed as “undruggable.”. The authors developed a cell-based functional assay for high-throughput screening to identify SMIs for steroid receptor coactivator-3 (SRC-3 or AIB1), a large and mostly unstructured nuclear protein. Without any SRC-3 structural information, the authors identified SI-2 (I) as a highly promising SMI for SRC-3. SI-2 meets all of the criteria of Lipinski’s rule [Lipinski et al. (2001) Adv Drug Deliv Rev 46(1-3):3-26] for a drug-like mol. and has a half-life of 1 h in a pharmacokinetics study and a reasonable oral availability in mice. As a SRC-3 SMI, SI-2 can selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct phys. interactions with SRC-3, and selectively induce breast cancer cell death with IC₅₀ values in the low nanomolar range (3-20 nM), but not affect normal cell viability. Furthermore, SI-2 can significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model. In a toxicol. study, SI-2 caused minimal acute cardiotoxicity based on a hERG channel blocking assay and an unappreciable chronic toxicity to major organs based on histol. analyses. The authors believe that this work could significantly improve breast cancer treatment through the development of “first-in-class” drugs that target oncogenic coactivators. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Product Details of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Metal-Controlled Switching of Enantioselectivity in the Mukaiyama-Michael Reaction of α,β-Unsaturated 2-Acyl Imidazoles Catalyzed by Chiral Metal-Pybox Complexes was written by Rout, Subhrajit;Das, Arko;Singh, Vinod K.. And the article was included in Journal of Organic Chemistry in 2018.Formula: C6H8N2O This article mentions the following:

Metal-directed switching of enantioselectivity in the Mukaiyama-Michael reaction of silyl enol ethers to α,β-unsaturated 2-acyl imidazoles using the same chiral indapybox ligand I has been reported. The utility of this approach has been portrayed in the synthesis of both enantiomers of optically active δ-keto acid and ester as well as 3,4-dihydropyran-2-one. Moreover, enantioswitching in the construction of the tertiary stereocenter adjacent to a gem-di-Me group has been achieved. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Analysis of the heterogeneous dynamics of imidazolium-based [Tf₂N^–] ionic liquids using molecular simulation was written by Androulaki, Eleni;Vergadou, Niki;Economou, Ioannis G.. And the article was included in Molecular Physics in 2014.Category: imidazoles-derivatives This article mentions the following:

The complex dynamic behavior of the imidazolium-based ionic liquids [C_nmim⁺][Tf₂N^–], n = 4, 8, 12 is examined at various temperatures and at atm. pressure using mol. dynamics simulation. An existing all-atom force field is further optimized in order to attain reasonable agreement with exptl. data for transport properties, such as self-diffusivities and viscosities. Dynamical heterogeneity phenomena are quantified through the calculation of the non-Gaussian parameter and the deviation of the self-part of the van Hove correlation function from the expected normal distribution. From this anal., ions that move faster or slower than expected are detected in the system. These subsets of ‘fast’ and ‘slow’ ions form individual clusters consisting of either mobile or immobile ions. Detailed anal. of the ions’ diffusion reveals preferential motion along the direction of the alkyl tail for the cation and along the vector that connects the two sulfur atoms for the anion. For the longest alkyl tails, the heterogeneity in the dynamics becomes more pronounced and is preserved for several nanoseconds, especially at low temperatures In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Category: imidazoles-derivatives).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem