Month: February 2023

Strong proton-shared hydrogen bonding in a methyl imidazole···HCl complex: evidence from matrix isolation infrared spectroscopy and ab initio computations was written by Sarkar, Shubhra;Sruthi, P. K.;Ramanathan, N.;Sundararajan, K.. And the article was included in New Journal of Chemistry in 2020.Recommanded Product: 3034-41-1 This article mentions the following:

Me imidazole (M-Imid)···HCl (1 : 1) complexes were studied using matrix isolation IR spectroscopy and ab initio computations. Computations using the MP2 level of theory with the aug-cc-pVDZ basis set predicted three complexes, where the global min. had a strong hydrogen-bonded N···H···Cl interaction with a binding energy of ~12 kcal mol^-1 (complex A). The first local min. had an H···π interaction (complex B) and the second local min. (complex C) was stabilized through combined hydrogen, halogen and pnicogen bonding (with a nitrogen atom as the pnicogen) interactions. Of the three complexes, the hydrogen-bonded complex A alone possesses exptl. significance. Experiments were performed by co-depositing M-Imid and HCl sep. in an N₂ matrix at a low temperature of ~12 K. The annealing of the low temperature matrix encouraged the formation of M-Imid-HCl complex A, which was subsequently probed using IR spectroscopy. Exptl., the vibrational shift of ~1720 cm_-1 was observed for the N₂ matrix, while harmonic frequency calculations indicated a shift of 1063 cm-1 in the H-Cl stretching region of the strong hydrogen-bonded complex A. The inclusion of anharmonicity in the calculations red-shifted the H-Cl stretching frequency further down to 1650 cm^-1, which was almost close to the exptl. value. It is inferred from this large exptl. red-shift of the stretching frequency of the proton donor that proton-shared hydrogen bonding is facilitated in the M-Imid-HCl system exptl. Using atoms in mols., energy decomposition and natural bond orbital analyses, the uniqueness of this strong proton-shared hydrogen bonding is established with respect to conventional hydrogen bonding. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A substituent- and temperature-controllable NHC-derived zwitterionic catalyst enables CO₂ upgrading for high-efficiency construction of formamides and benzimidazoles was written by Yu, Zhaozhuo;Li, Zhengyi;Zhang, Lilong;Zhu, Kaixun;Wu, Hongguo;Li, Hu;Yang, Song. And the article was included in Green Chemistry in 2021.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

Chemocatalytic upgrading of the greenhouse gas CO₂ to valuable chems. and biofuels has attracted broad attention in recent years. Among the reported approaches, N-formylation of CO₂ with an amine is of great significance due to its versatility in the construction of N-containing linear and cyclic skeletons. Herein, a stable N-heterocyclic carbene-carboxyl adduct (NHC-CO₂) was facilely prepared and could be used as a recyclable zwitterionic catalyst for efficient CO₂ reductive upgrading via either N-formylation or further coupling with cyclization under mild conditions (25°C, 1 atm CO₂) using hydrosilane as a hydrogen source. More than 30 different alkyl and aromatic amines could be transformed into the corresponding formamides or benzimidazoles with remarkable yields (74%-98%). The electronic effect of the introduced substituent on NHC-CO₂ was found to evidently affect the thermostability and nucleophilicity of the zwitterionic catalyst, which is directly correlated with its catalytic activity. Moreover, NHC-CO₂ could supply CO₂ by in situ decarboxylation at a specific temperature that is dependent on the introduced substituent type. Exptl. and computational studies showed that the carboxyl species on NHC-CO₂ was not only a nucleophilic center, but also a C1 source which rapidly captures or substitutes ambient CO₂ during hydrosilylation. In addition, a simple and green conceptual process was designed for the product purification and catalyst recycling, with a good feasibility for small-scale production In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diversity-Oriented Synthesis toward Aryl- and Phosphoryl-Functionalized Imidazo[1,2-a]pyridines was written by Gernet, Aurelie;Sevrain, Nicolas;Volle, Jean-Noel;Ayad, Tahar;Pirat, Jean-Luc;Virieux, David. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 69214-09-1 This article mentions the following:

We report herein an efficient synthesis of diversely polysubstituted imidazo[1,2-a]pyridines, a family of aza-heterocycles endowed with numerous biol. properties, through a sequence involving two consecutive palladium-catalyzed cross-coupling reactions. First, we demonstrated that a Hirao coupling occurred straightforwardly in high yields at positions 3, 5, and 6 of imidazopyridine derivatives, giving access to a wide variety of substituted phosphonates, phosphinates, and phosphine oxides. In a second step, direct CH-arylation of phosphorylimidazopyridines with aryl halides was found to be effective and fully selective, leading to 3-aryl-substituted imidazopyridines in moderate to high yields depending on steric hindrance. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Recommanded Product: 69214-09-1).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 69214-09-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A structure-activity relationship study of the affinity of selected imidazo[1,2-a]pyridine derivatives, congeners of zolpidem, for the ω₁-subtype of the benzodiazepine receptor was written by Lange, Jerzy;Karolak-Wojciechowska, Janina;Wejroch, Krystyna;Rump, Slawomir. And the article was included in Acta Poloniae Pharmaceutica in 2001.Electric Literature of C18H21N3 This article mentions the following:

A series of 6-substituted 2-aryl-N,N-dimethylimidazol[1,2-a]pyridine-3-acetamides, congeners of zolpidem and alpidem, was synthesized and tested in vitro for binding with the benzodiazepine receptor in the competition with ³H-zolpidem as an ω₁-selective radioligand. Mol. electrostatic potential (MEP) and the HOMO and LUMO energies were calculated for the compounds by semi-empirical quantum chem. methods. The lipophilicity parameter of the compounds, expressed as the logarithm of the octanol-water partition coefficient (log P), was calculated; alternatively, standard values of the Hansch hydrophobic substituent constants π were used. In agreement with earlier investigations on the benzodiazepine receptor ligands with a high preference for the ω₁-subtype, a quant. correlation of the biol. data with mol. parameters has revealed a significant dependence (r=0.954) of the binding affinity (IC₅₀) on the deepest MEP min., in this case associated with the amide carbonyl oxygen atom. The lipophilicity parameters were found to be of lower significance. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Electric Literature of C18H21N3).

N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C18H21N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancing onset of action of candesartan cilexetil by the preparation of fast dissolving film containing loaded Candesartan cilexetil nanoemulsion was written by Sahil;Malviya, Sarvesh Jain;Khune, Kalyani;Jain, Puspendra Kumar. And the article was included in World Journal of Pharmaceutical Research in 2019.COA of Formula: C33H34N6O6 This article mentions the following:

Candesartan cilexetil has limitation both in less bioavailability and onset of action. Therefor formulation to optimized the use of candesartan cilexetil. The purpose of this study was to develop nanoemulsion by using an appropriate oils, surfactant and co surfactant. Nanoemulsion was prepared by the spontaneous mixture of labrafil 2125, kolliphor RH 40 and PEG 400 with the ratio (0.5:9:5). The nanoemulsions were prepared by aqeous titration method. The solubility of drug was checked in different solvents, surfactant, oils and co surfactant in regulate to select the best solubilizing componenets for the preparation of nanoemulsion and then pseudoternary phase diagram was used as a useful device to evaluate the nanoemulsion area. The film was prepared by using a polymers (HPMC 5, HPMC 6, HPMC 15, and HPMC 50) and plasticizers. The method used for the preparation of film was petri plate method. It is an easy and low cost price method. The main purpose behind for the preparation of film was enhanced the onset of action and reduce the side effect. The evaluation of film was Invitro dissolution release, weight variation, folding endurance, film thickness, disintegration time, drug content release determination by used a zero order, first order, higuchi, koshmeyer plot graphs. The serious feature was type and ratio of oils, surfactant, co surfactant, and polymer and plasticizer concenteration influenced the film characters. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5COA of Formula: C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pharmacokinetics of liposomal curcumin (Lipocurc) infusion: effect of co-medication in cancer patients and comparison with healthy individuals was written by Bolger, Gordon T.;Licollari, Albert;Tan, Amin;Greil, Richard;Vcelar, Brigitta;Greil-Ressler, Sigrun;Weiss, Lukas;Schonlieb, Charlotte;Magnes, Teresa;Radl, Bianca;Majeed, Muhammed;Sordillo, Peter P.. And the article was included in Cancer Chemotherapy and Pharmacology in 2019.Related Products of 145040-37-5 This article mentions the following:

Purpose: Investigation of the impact of co-medication on the plasma levels of curcumin and tetrahydrocurcumin (THC) in cancer patients and a comparison of the pharmacokinetics of curcumin and plasma levels of THC between cancer patients and healthy individuals following i.v. infusion of Lipocurc (liposomal curcumin). Methods: Correlation anal. was used to determine the impact of co-medication on infusion rate normalized plasma levels of curcumin and THC in cancer patients and to compare the plasma levels of curcumin and THC at different infusion rates between cancer patients and healthy individuals. In vitro hepatocyte and red blood cell distribution experiments were conducted with Lipocurc to support clin. findings. Plasma concentration time data were analyzed by the non-compartmental method to determine and compare the pharmacokinetic parameters of curcumin in cancer patients and healthy individuals. Results: Of 44 co-medications studied, three medications targeting the renin-angiotensin system, Lisinopril, Ramipril, and Valsartan elevated plasma levels of curcumin and THC in three cancer patients infused with Lipocurc. Cell distribution experiments indicated that the disposition of curcumin in red blood cells may be a target for elevation of the plasma levels of curcumin. Plasma levels of curcumin in cancer patients increased to a greater extent with increased infusion rate compared to healthy individuals. Upon termination of infusion, the elimination phase for curcumin was shorter with a shorter terminal half-life and smaller volume of distribution for curcumin in cancer patients compared to healthy individuals. Conclusion: Either co-medications or health status, or both, can impact the pharmacokinetics of curcumin infusion (as Lipocurc) in cancer patients. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Related Products of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

β-Carotene: A green, inexpensive, and convenient solvatochromic probe for the determination of solvent polarizability was written by Loffredo, Carina;Pires, Paulo Augusto R.;Imran, Muhammad;El Seoud, Omar A.. And the article was included in Dyes and Pigments in 2013.Application of 21252-69-7 This article mentions the following:

Solvent polarizability has been previously determined by using the solvatochromic probe 3,20-di-tert-butyl-2,2,21,21-tetramethyl-3,5,7,9,11,13,15,17,19-docosanonaene whose synthesis involves 15 steps. We show here that the natural dye β-carotene, 1,1′-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethylcyclohexene], can be conveniently employed for the accurate determination of the same solvent property. This conclusion is based on both theor. calculations and exptl. data. The former includes free energies of solvation, and the wavenumber of the longest wavelength (i.e., the solvatochromic) transition. Both quantities for β-carotene correlate linearly with the corresponding values of the docosanonaene, with slopes and correlation coefficients of practically unity. The plot of exptl. calculated solvent polarizability of β-carotene vs. that of the docosanonaene was found to be linear for 68 solvents. Previously unknown solvent polarizability values are reported for eight ROCH₂CH₂OH (R = C₁ to C₁₀) and four 1-allyl-3-R-imidazolium chloride ionic liquids (R = C₆ to C₁₀). The dependence of solvent polarizability on the number of carbon atoms in the hydrocarbon chains of several classes of solvents is calculated, it shows the importance of van der Waals interactions in ionic liquids In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Representation of phase behavior of ionic liquids and their mixtures using various forms of cubic-two-state equation of state was written by Haghtalab, Ali;Shojaeian, Abolfazl. And the article was included in Fluid Phase Equilibria in 2017.Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

In this work, in addition of Soave-Redlich-Kwong (SRK) equation of state, two other alternative cubic models such as Peng- Robinson (PR) and Cubic Square Well (CSW) EoSs are combined with the Two-State Association Model (TSAM) and the new forms of the Cubic-Two-State equation of state (CTS EoS) as PR-TS and CSW-TS are presented. In the beginning, the present models are used to correlate the saturated vapor pressure and liquid d. of pure water, alcs. and phenol. The models are also employed to predict vapor molar volume and second virial coefficients of pure compounds to explore the predictability of the different type of the CTS models. Also, the liquid d. of different pure ionic liquids (ILs) at various temperatures from 298.15 K up to 500 K and pressure from 0.1 MPa up to 59.59 MPa is correlated and the parameters of the CTS models are obtained. Following successful application of the models for the pure components, using one temperature independent binary interaction parameter, the SRK-TS and PR-TS models are applied to predict the vapor-liquid equilibrium of the several binary mixtures consists of IL with non-association and association components at various temperatures from 298.15 K up to 363.15 K and pressure from 0.09 kPa up to 216 kPa. The results of the SRK-TS and PR-TS models for pure and binary systems containing ILs are in very good agreement with experiments and also are compared with various equations of states that show better results. In overall for the systems that are presented in this work, the PR-TS model shows slightly better results with respect to the SRK-TS model specially in prediction, and PR-TS and SRK-TS models present superiority with respect to the CSW-TS EoS. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dissolution of Maize Starch in Aqueous Ionic Liquids: The Role of Alkyl Chain Length of Cation and Water:Ionic Liquid Ratio was written by Ren, Fei;Wang, Jinwei;Yu, Jinglin;Xiang, Fengjuan;Wang, Shuo;Wang, Shujun;Copeland, Les. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.Recommanded Product: 79917-89-8 This article mentions the following:

The dissolution behavior of maize starch in water:ionic liquid (IL) mixtures at ambient temperature (22-23 °C) was studied. The ionic liquids used were 1-butyl-3-methylimidazolium chloride ([C₄ mim][Cl]), 1-propyl-3-methylimidazolium chloride ([C₃ mim][Cl]), and 1-ethyl-3-methylimidazolium chloride ([C₂ mim][Cl]). Structural analyses indicated that long- and short-range mol. order in the starch decreased with decreasing water:IL ratio. At water:IL ratios of 10:1 and 5:1, the extent of disruption of starch structure followed the order [C₄ mim][Cl] > [C₃ mim][Cl] > [C₂ mim][Cl]. At lower water:IL ratio (2:1), the complete disruption of starch granule morphol. and ordered structures in water:[C₃ mim][Cl] and water:[C₂ mim][Cl] mixtures indicated these mixtures were more effective in dissolving starch than water:[C₄ mim]Cl mixture Results from rheol., FTIR, and ¹H NMR analyses of water:IL mixtures showed that as water:IL ratio decreased, the viscosity of solutions increased, the interaction between IL and water decreased, and the interaction between the cation and the anion increased. Stronger interaction between the IL and water and higher viscosity of water:IL mixtures were noted for cations with longer alkyl chains. Our results clearly showed that both the alkyl chain length of cations and water:IL ratio played key roles in the dissolution of starch, predominantly by affecting the interaction between ILs and water and viscosity of water:IL mixtures In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, formulation, and characterization of stearic acid-based solid lipid nanoparticles of candesartan cilexetil to augment its oral bioavailability was written by Mahajan, Anu;Kaur, Satvinder. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2018.Reference of 145040-37-5 This article mentions the following:

Objective: Poor aqueous solubility and suboptimal oral bioavailability hamper the therapeutic efficacy of candesartan cilexetil (CDC). This study is designed to prepare solid lipid nanoparticle (SLN) of CDC and to enhance the oral absorption of CDC compared with free drug suspension. The development and characterization of CDC-loaded SLN, using stearic acid as main encapsulating lipid, stabilized with poloxamer188 using “modified emulsification-ultrasonication technique.” Results: CDC-SLN with a total drug content of 88.33 ± 1.23% and entrapment efficiency of 78.28 ± 1.91%, with an average particle size of 197.9 nm and zeta potential value -21.3 mV, was prepared Differential scanning calorimetry and powder X-ray diffraction (PXRD) results confirmed the mol. encapsulation of the drug in amorphous state. CDC-SLN released 60.43% of drug in comparison to 17.11% released by CDC suspension in 24 h (p<0.05). The results of pharmacoKinetic studies in rat showed that AUC0-t of CDC-SLN was significantly enhanced over 3-folds than that of free drug suspension (p<0.05). Conclusion: SLN of CDC could be successful in improving the oral bioavailability of poorly soluble CDC. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem