Month: February 2023

Kinetic analysis of the complete mechanochemical synthesis of a palladium(II) carbene complex was written by Allenbaugh, Rachel J.;Zachary, Jonathon R.;Underwood, A. Nicole;Bryson, J. Dillion;Williams, Joseph R.;Shaw, Angela. And the article was included in Inorganic Chemistry Communications in 2020.Recommanded Product: 1632-83-3 This article mentions the following:

Benzimidazoline-2-ylidene complexes of palladium(II) were synthesized mechanochem. in a vibratory ball mill. Complete syntheses began with preparation of benzimidiazolium halides from com. available starting materials. These “greener chem.” syntheses proceed in high yield and require minimal purification using environmentally benign solvents. Kinetic anal. shows that liquid assisted grinding impedes the production to benzimidazolium halides while enhancing the production of the palladium-carbene complex. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel Mn(II)-Based Metal-Organic Frameworks Isolated in Ionic Liquids was written by Xu, Ling;Kwon, Young-Uk;de Castro, Baltazar;Cunha-Silva, Luis. And the article was included in Crystal Growth & Design in 2013.HPLC of Formula: 79917-89-8 This article mentions the following:

An unprecedented series of Mn²⁺-based metal-organic framework (MOF) materials prepared and isolated in ionic liquids (ILs) is reported. Ionothermal reactions of Mn(OAc)₂ with H₃btc (benzene-1,3,5-tricarboxylic acid) in two groups of [rmi]X (rmi = 1-alkyl-3-methylimidazolium; r = Et or Pr, X = Cl, Br, or I) ILs produced three slightly different 3D MOFs formulated as [rmi][Mn(btc)] [r = Et (1), Pr (2), and (3)], whose architectures can be envisaged as (3,6)-connected pyr topol. nets. Compounds 1–3 are the preferred products when the metal center is half filled d-shelled Mn with the cations of ILs being [emi]⁺ or [pmi]⁺. The comparison of the ionothermal synthesized M-btc systems suggests a significant combinatorial influence of metal-direction and ILs’ cationic template, contrasting with subtle effect of ILs’ halides on the MOF structures. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8HPLC of Formula: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation was written by Roberts, Bryan;Liptrot, David;Alcaraz, Lilian. And the article was included in Organic Letters in 2010.SDS of cas: 25676-75-9 This article mentions the following:

A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9SDS of cas: 25676-75-9).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 25676-75-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of salt formation on γ-cyclodextrin solubilization of irbesartan and candesartan and the chemical stability of their ternary complexes was written by Jansook, Phatsawee;Hnin, Hay Marn;Praphanwittaya, Pitsiree;Loftsson, Thorsteinn;Stefansson, Einar. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Electric Literature of C33H34N6O6 This article mentions the following:

Angiotensin II receptor blockers (ARBs) are unstable compounds and have relatively low aqueous solubility, which may hamper their bioavailability. The present study aimed to increase the aqueous solubility of ARBs by the formation of cyclodextrin (CD) inclusion complex and determine their chem. stability in aqueous solutions The pH- solubility of drugs and their phase-solubility profiles were determined, and the results showed that the solubility of drugs increased by forming inclusion complexes with γ-cyclodextrin (γCD) and by increasing their intrinsic solubility in phosphate buffer (pH 7.5). The formation of irbesartan/γCD (IRB/γCD) and candesartan cilexetil/γCD (CAC/γCD) inclusion complexes was confirmed by mol. docking. To enhance the γCD solubilization of drugs, salt formation using various organic salts was also investigated. Of these, Tris was the most powerful, followed by sodium acetate, as they significantly increased the γCD solubilization of IRB and CAC. However, chem. instability was observed, particularly at high salt concentrations, where they provided a higher IRB and CAC solubility Thus, the balance of optimum drug solubility and its chem. stability in aqueous solutions should be considered in formulation development. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Infrared spectra and structure of salts of nitroimidazoles was written by Epishina, L. V.;Slovetskii, V. I.;Osipov, V. G.;Lebedev, O. V.;Khmel’nitskii, L. I.;Sevost’yanova, V. V.;Novikova, T. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1967.COA of Formula: C4H5N3O2 This article mentions the following:

The ir spectra of nitroimidazoles and their salts indicate that salt formation involves only the NO2 group, with the formation of an isoimidazole ring. In polynitroimidazoles (I), only one NO2 group is involved as shown. The N-O absorption bands at �550 and �350 cm.-1 in mononitroimidazoles disappear on salt formation and bands at �180 and �50 cm.-1 appear. In salts of I, some of the N-O absorption in the uncharged NO2 group remains. N-Nitroimidazoles are characterized by an antisym. N-O vibration absorption band at �640 cm.-1 and a sym. one at �330 and �280 cm.-1 The presence of a C(NO2)3 group leads to 3 bands at 1600-1630 cm.-1 and usually to 2 bands at 1300-1325 cm.-1 In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1COA of Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) amino-protecting group: use in the solid-phase synthesis of pyrrole-imidazole polyamides was written by Choi, Jin Seok;Lee, Younjoo;Kim, Eunmyoung;Jeong, Nakcheol;Yu, Hosung;Han, Hogyu. And the article was included in Tetrahedron Letters in 2003.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chem. using two Tsc-protected amino acids I (X = CH, N). In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DFT Study of the Energetic and Noncovalent Interactions between Imidazolium Ionic Liquids and Hydrofluoric Acid was written by Velarde, Marco V.;Gallo, Marco;Alonso, P. A.;Miranda, A. D.;Dominguez, J. M.. And the article was included in Journal of Physical Chemistry B in 2015.Application of 915358-85-9 This article mentions the following:

In this work, we evaluated the energetic interactions between imidazolium ionic liquids (ILs) and hydrofluoric acid, as well as the cation-anion interactions in ILs. We used DFT calculations that include dispersion corrections employing the PBE and M06 functionals. We tested 22 ILs, including [C₄MIM][PF₆], [C₄MIM][NTf₂], and [C₄MIM][CH₃COO], obtaining interaction energies in the range of -27 to -13 kcal/mol with the PBE functional. The NCI (noncovalent interaction) index developed by Yang and collaborators also was used for mapping the key noncovalent interactions (hydrogen bonds, van der Waals, and steric repulsions) between the anions and cations of ILs and also for interactions of ILs with hydrofluoric acid (HF). The results obtained show that the anions have a stronger effect with respect to cations in their capacity for interacting with hydrofluoric acid, and the strongest interaction energies occur in systems where the key noncovalent interactions are mainly hydrogen bonds. The [C₄MIM][PF₆], [C₄MIM][NTf₂], and [C₄MIM][BF₄] ionic liquids displayed the weakest cation-anion interactions. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Application of 915358-85-9).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 915358-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The preparation of some heteroaromatic and aromatic aldehydes was written by Katritzky, Alan R.;He, Hai-Ying;Long, Qiuhe;Cui, Xilin;Level, Julian;Wilcox, Allan L.. And the article was included in ARKIVOC [online computer file] in 2000.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Heteroaromatic α- and β-carboxaldehydes were prepared by the formylation with DMF of α-lithio benzofuran, benzothiophene, N-methylbenzimidazole and 10-methylphenothiazine obtained by direct lithiation and β-lithio compounds from lithium-bromine exchange. Dialkoxybenzaldehydes were prepared by the formylation of dialkoxybenzenes with hexamethylenetetramine (HMTA) or by the alkylation of dihydroxybenzaldehydes with alkyl bromides or iodides. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Silica-immobilized ionic liquid Bronsted acids as highly effective heterogeneous catalysts for the isomerization of n-heptane and n-octane was written by Dhar, Abhishek;Siva Kumar, Nadavala;Khimani, Mehul;Al-Fatesh, Ahmed S.;Ibrahim, Ahmed A.;Fakeeha, Anis H.;Patel, Hiren;Vekariya, Rohit L.. And the article was included in RSC Advances in 2020.Quality Control of 1-Methylbenzimidazole This article mentions the following:

Metal-free imidazolium-based ionic liquid (IL) Bronsted acids 1-Me imidazolium hydrogen sulfate [HMIM]HSO₄ and 1-Me benzimidazolium hydrogen sulfate [HMBIM]HSO₄ were synthesized. Their physicochem. properties were investigated using spectroscopic and thermal techniques, including UV-Vis, FT-IR, ¹H NMR, ¹³C-NMR, mass spectrometry, and TGA. The ILs were immobilized on mesoporous silica gel and characterized by FT-IR spectroscopy, SEM, Brunauer-Emmett-Teller anal., ammonia temperature-programmed desorption, and thermogravimetric anal. [HMIM]HSO₄@silica and [HMBIM]HSO₄@silica have been successfully applied as promising replacements for conventional catalysts for alkane isomerization reactions at room temperature Isomerization of n-heptane and n-octane was achieved with both catalysts. In addition to promoting the isomerization of n-heptane and n-octane (a quintessential reaction for petroleum refineries), these immobilized catalysts are non-hazardous and save energy. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Quality Control of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An approach to H₂S removal from light crude oils using synthetic scavengers based on long chain alkylated ionic was written by Pasbana, Iiguids A. A.;Beigia, A. A. Miran;Hazrati, N.. And the article was included in Afinidad in 2020.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

In this research, the effect of imidazolium based ionic liquids as scavengers on reducing and minimizing the amount of hydrogen sulfide in Iranian crude oils has been studied. To improve the quality of crude oil and increasing the value added of producing and exporting of crude oil, firstly, cold stripping was performed and effective parameters of process on the efficiency was investigated. In the next step, four imidazolium-based ionic liquid samples, were synthesized and their effects on reduction of H₂S from four samples of Iranian light crude oils were tested. The design of the experiments and the results of the study were done using the software Minitab 14. For this purpose, the effect of the parameters of the ratio of scavenger concentration, temperature and contact time with crude oil on the reduction of H₂S was studied. The results of the study show that ionic liquid scavenger yields a better efficiency; with optimal conditions (concentration of 1200 ppm, temperature of 45° C in 20 min of time) H₂S reduces in crude oil from 550 to less than 15 ppm. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem