Month: February 2023

Synthesis, characterization and thermal properties of thiosalicylate ionic liquids was written by Wilfred, Cecilia Devi;Mustafa, Fadwa Babiker. And the article was included in Journal of Chemical Sciences (Bangalore, India) in 2013.Electric Literature of C7H13ClN2 This article mentions the following:

In an attempt to produce new functionalized ionic liquids, a series of thiosalicylate ionic liquids based on imidazolium, ammonium, phosphonium, choline and pyrrolidinium cations were synthesized. The compounds were characterized by Infra Red (IR), NMR (NMR) and mass spectra (ESI-MS). Their glass-transition temperatures, m.ps. and decomposition temperatures have been measured. Physicochem. properties of ionic liquids are influenced by alkyl chain length and nature of the cation of ionic liquids In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supramolecular complexes formed by dimethoxypillar[5]arenes and imidazolium salts: a joint experimental and computational investigation was written by D’Anna, Francesca;Rizzo, Carla;Vitale, Paola;Marullo, Salvatore;Ferrante, Francesco. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 1-Octyl-1H-imidazole This article mentions the following:

To gain more insights into the factors acting on the stability of complexes formed by pillar[5]arenes, we investigated the interaction of dimethoxypillar[5]arene with some 1-(n-alkyl)-3-(9-anthracenylmethyl)-imidazolium based organic salts. In particular, we used salts differing in not only the anion nature ([Cl^–], [BF₄^–], [NTf₂^–] and [SbF₆^–]) and alkyl chain length (Bu, octyl and dodecylimidazolium derivatives), but also the presence of a hydrogenated or fluorinated tail (octyl and perfluorooctylimidazolium derivatives). Host-guest systems were analyzed in solution, solid state and gas phase, using a combined approach of different techniques like fluorescence, ¹H NMR, ESI-MS, DSC and DFT calculations Data collected show that the complex stability is heavily affected by solvent nature. Furthermore, solvent being the same, it increases with the decrease of the alkyl chain length and the anion coordination ability. The joint information obtained from ¹H NMR and DFT calculations allows drawing a picture of the complex geometry. On the other hand, fluorescence investigation on the solid state evidences the occurrence of an aggregation enhanced emission process for these systems. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquids for the control of the morphology in poly(vinylidene fluoride-co-hexafluoropropylene) membranes was written by Saiz, Paula G.;Lopes, Ana Catarina;Eizagirre Barker, Simone;Fernandez de Luis, Roberto;Arriortua, Maria Isabel. And the article was included in Materials & Design in 2018.Reference of 35487-17-3 This article mentions the following:

The development of polymer membranes with tailored micro-morphol. and wettability is a demand in the areas of filtration, sensors, and tissue engineering, among others. The thermoplastic copolymer poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP), is one of the most widely used polymers for these applications due to its good mech. and thermal properties, biocompatibility and low d. Although the control of the PVDF-HFP morphol. is a complicated task, the introduction of ionic liquids (ILs) in the PVDF-HFP matrix opens new perspectives in this area. This work consists of a systematic study of three different protic ionic liquids ([dema][TfO], [MIm][NTf₂] and [MIm][Cl]) in the control of PVDF-HFP membranes properties. Different preparation conditions are also analyzed. These results demonstrate how several parameters such as morphol., water absorption capacity and mech. properties vary depending on the production methodol. employed and on the choice of incorporated IL. Pores of different sizes, spherulites and compact structures have been obtained, as well as hydrophilic and highly hydrophobic structures. These results show that ILs play a key role in the optimization of polymer properties and given the large number of available ILs, open up new possibilities for the development of polymer membranes suitable for applications where specific morphologies are desirable. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Reference of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solubility of H₂S and CO₂ in imidazolium-based ionic liquids with bis(2-ethylhexyl) sulfosuccinate anion was written by Akhmetshina, Alsu I.;Petukhov, Anton N.;Gumerova, Olesya R.;Vorotyntsev, Andrey V.;Nyuchev, Alexander V.;Vorotyntsev, Ilya V.. And the article was included in Journal of Chemical Thermodynamics in 2019.Electric Literature of C4H7ClN2 This article mentions the following:

Herein, we studied the absorption of H₂S and CO₂ in 1-methylimidazolium bis(2-ethylhexyl) sulfosuccinate ([mim][doc]) and 1-buthyl-3-methylimidazolium bis(2-ethylhexyl) sulfosuccinate ([bmim][doc]) at various temperatures and partial gas pressures. The choice of the [doc] anion was determined by the ability of bulky moieties along with the polar functional groups to enhance the solubility of acidic gases, as confirmed during the volumetric measurements of gases solubility It was shown that the protic cation presence determines a significant reduction of the CO₂ and H₂S solubilities as well as the thermal stability of ILs. There were found that [bmim][doc] tends to have higher absorption capacity toward acidic gases compared with [mim][doc]. The solubility of hydrogen sulfide, characterized by the Henry’s Law constant, in [bmim][doc] and [mim][doc] turned out nearly 4-5 and 1.5-2 times higher than in conventional ionic liquids resp. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Electric Literature of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes was written by Lessi, Marco;Nania, Attilio;Pittari, Melania;Lodone, Laura;Cuzzola, Angela;Bellina, Fabio. And the article was included in Catalysts in 2021.Electric Literature of C8H8N2 This article mentions the following:

A simple protocol for the Pd(II)/Cu(II)-promoted intermol. cross-dehydrogenative coupling (CDC) of 5-arylimidazoles, benzimidazoles, benzoxazole and 4,5-diphenylimidazole at their C-2 position with functionalized styrenes. This specific CDC, known as the Fujiwara-Moritani reaction or oxidative Heck coupling, also allowed the C-4 alkenylation of the imidazole nucleus when both 2 and 5 positions were occupied. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tuning of the dienophilic reactivity of imidazo[1,2-a]pyridine: a comparison of DFT and dispersion-corrected DFT calculations was written by Maheshwari, Pooja;Gupta, Raakhi;von Hopffgarten, Moritz;Bansal, Raj K.. And the article was included in Bulletin of the Chemical Society of Japan in 2013.COA of Formula: C7H5N3O2 This article mentions the following:

A comparative study of the DFT calculations with and without dispersion correction for the determination of the relative activation energy barriers and reaction energies of the normal electron demand Diels-Alder (NED DA) reactions of imidazo[1,2-a]pyridine and its derivatives with 1,3-butadiene at the B3LYP/6-31+G** level reveals that on inclusion of the dispersion correction, the relative activation energy barriers are lowered by ca. 10-13 kcal mol^-1 whereas relative reaction energies are increased by ca. 9-13 kcal mol^-1 as compared to the DFT calculations without dispersion correction. Similar results are obtained for the reverse electron demand (RED) DA reactions of imidazo[1,2-a]pyridine and its derivatives with tetrachloro-o-benzoquinone. The relative free energies of solvation of different species determined from SCRF calculations allow to detect solvent-induced geometry relaxation of the reactant mols. and the transition states which rationalizes lowering of the relative activation energies in methylene chloride. The reactions are found to occur without the involvement of the reactants complexes. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3COA of Formula: C7H5N3O2).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C7H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Thermal behavior analysis as a valuable tool for comparing ionic liquids of different classes was written by Mezzetta, Andrea;Perillo, Vincenzo;Guazzelli, Lorenzo;Chiappe, Cinzia. And the article was included in Journal of Thermal Analysis and Calorimetry in 2019.SDS of cas: 21252-69-7 This article mentions the following:

The thermal behavior of I [R = H, Br; X = Br, NTf₂; n = 2, 6; m = 1, 4] and II ILs, belonging to two structurally related families with either bromide or Tf₂N as counteranion, was analyzed. For bromide mono- I and dicationic ionic liquids II (DILs), thermal gravimetric anal. showed similar decomposition events, with only small gain in stability for a few members of the latter class. Conversely, all Tf₂N DILs displayed higher stabilities (up to 34 K) than the corresponding monocations, thus highlighting the different role played by the two counteranions. Mono- and dicationic ILs bearing a reactive group on the imidazolium substituent resulted instead the least stable ILs studied. Differential scanning calorimetry anal. of most of the (D)ILs only showed glass transition temperatures, a behavior in agreement with the broad liquid range of ILs. The impact of the cationic structure and/or of the type of anion on the above-mentioned transition temperatures were studied. The apparent activation energy (Ea) and the fragility index (m) for some (D)ILs had also been obtained. Finally, a few bromide (D)ILs presented peculiar thermal events. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7SDS of cas: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.SDS of cas: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

peri-Substituted imidazo[1,2-a]pyridines. A new reductive elimination reaction was written by Rees, Charles W.;Smith, David I.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.SDS of cas: 88047-55-6 This article mentions the following:

A new reductive elimination reaction of 3,5-disubstituted imidazo[1,2-a]pyridines I (R, R¹ = Br, NO₂) with N₂H₄ in hot EtOH is reported. A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene into 1,3-dichloro-4,6-dinitrobenzene. A variety of other 3-nitro-5-substituted imidazo[1,2-a]pyridines I (R = NO₂, R¹ = CO₂Me, CONHNH₂, CON₃, NH₂, NHCO₂Me, N₃, etc.) are described, but these could not be cyclized. The 3-amino-5-methoxycarbonyl derivative I (R = NH₂, R¹ = CO₂Me) cyclizes to the imidazoindazole II with NaOMe. In the experiment, the researchers used many compounds, for example, Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6SDS of cas: 88047-55-6).

Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 88047-55-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enthalpy characteristics of mononitro derivatives heterocyclic compounds was written by Kostikova, L. M.;Miroshnichenko, E. A.;Matyushin, Y. N.;Vorob’ev, A. B.;Inozemtcev, J. O.. And the article was included in International Annual Conference of ICT in 2002.Synthetic Route of C4H5N3O2 This article mentions the following:

The enthalpies of formation in the standard condition and gas phase some mononitro derivatives heterocyclic compounds are exptl. determined The cleanliness of some compounds is measured by the method of the curve melting. The substances burnt in the solution of the di-Me phthalate for prevention of explosion and ensuring of completeness of combustion. The thermal effect of reaction of dissolution of substances in the di-Me phthalate is measured on the microcalorimeter and it was taken into account at calculation of the enthalpy of formation of the studied compounds Efficient energies of introduction nitro groups in the heterocycles are found. The change of the enthalpy of formation at introduction of electroneg. fragments to atoms of carbon and nitrogen is analyzed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Synthetic Route of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quaternization of azido-N-heteroarenes with Meerwein reagent: A straightforward synthesis of 2-azido(benzo)imidazolium and related azido-N-heteroarenium tetrafluoroborates was written by Li, Yan;Wan, Ting-Biao;Guo, Bin;Qi, Xiao-Wen;Zhu, Chifan;Shen, Mei-Hua;Xu, Hua-Dong. And the article was included in Tetrahedron Letters in 2022.Synthetic Route of C8H8N2 This article mentions the following:

The 2-azido(benzo)imidazolium salts e.g., I have been made through quaternization of 2-Azido(benzo)imidazoles e.g., II with Meerwein reagent at ambient conditions. This one-pot protocol is also applicable to 4 or 3-azidopyridines e.g., III and appropriate azido(iso)quinolines e.g., IV to prepare correlative azido-N-heteroarenium salts e.g., I. When compared with their precursors, improved diazotransfer reactivity was observed for several representative azido-N-heteroarenium salts e.g., I in reaction with di-Et malonate. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem