Month: February 2023

Luminescent Eu^III Complexes Immobilized on a Vermiculite Clay Surface was written by Silva, Haryane R. M.;Fonseca, Maria G.;Espinola, Jose Geraldo P.;Brito, Hermi F.;Faustino, Wagner M.;Teotonio, Ercules E. S.. And the article was included in European Journal of Inorganic Chemistry in 2014.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Vermiculite clays were leached with HNO₃ and functionalized with (3-chloropropyl)trimethoxysilane. The resulting materials were modified with the methylimidazolium (MID) group to yield cationic surfaces. These materials were characterized by IR spectroscopy, elemental analyses, and sp. surface area. Tetrakis(尾-diketonate)europate(III) complexes, [EuL₄]^– [L = dibenzoylmethane (DBM) and thenoyltrifluoroacetone (TTA)], were immobilized on the vermiculite surface containing the imidazolium cation to yield hybrid surfaces named Vx-MID-EuL₄ (x = 0, 1, and 2), in which x represents the nitric acid concentration in mol L^-1 that was used in the leaching process. The highest luminescence intensities of the intraconfigurational-4f ⁵D₀鈫?sup>7FJ transitions (for which J = 0, 1, 2, 3, and 4) arising from [EuL₄]^– complexes were presented by the hybrid materials containing the amount of imidazolium cation, which depend on the leaching process. The excitation and emission spectra suggested an efficient intramol. energy-transfer process from ligand-to-Eu³⁺ ion in the supported materials. The photoluminescent properties of the hybrid materials were studied based on the emission quantum efficiency (畏), exptl. intensity parameters 惟₂ and 惟₄, and Einstein’s emission coefficient (A_0J). The values of these parameters for the V₂-MID-EuL₄ surface are close to those assigned to the [EuL₄]^– isolated complexes, which indicates that hybrid vermiculite materials are promising red phosphors. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application In Synthesis of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of halogen derivatives of N-methylimidazole was written by El Borai, M.;Moustafa, A. H.;Anwar, M.;Abdel Hay, F. I.. And the article was included in Polish Journal of Chemistry in 1981.Recommanded Product: 4-Bromo-1-methylimidazole This article mentions the following:

1-Methylimidazole (I) was converted to 2-halo-, 2,5-dihalo-, 5-halo-, 2,4-dihalo-, 4,5-dihalo-, 4-halo-, and 2,4,5-trihalo-1-methylimidazoles. I was treated with BuLi and Br₂ to give 2-bromo-1-methylimidazole. The reaction of I with N-bromosuccinimide gave 5-bromo-1-methylimidazole. I reacted with iodine and HIO₃ to give 4,5-diiodo-1-methylimidazole. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Recommanded Product: 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Insights into the interplay between molecular structure and diffusional motion in 1-alkyl-3-methylimidazolium ionic liquids: a combined PFG NMR and X-ray scattering study was written by Martinelli, A.;Marechal, M.;Oestlund, A.;Cambedouzou, J.. And the article was included in Physical Chemistry Chemical Physics in 2013.Category: imidazoles-derivatives This article mentions the following:

We report on how the local structure and the diffusional motion change upon increasing the alkyl chain length in 1-alkyl-3-methylimidazolium cation ionic liquids This study has been performed by combining pulsed field gradient (PFG) NMR spectroscopy and small angle X-ray scattering (SAXS) experiments The cationic side chain length varies from Et (n = 2) to hexadodecyl (n = 16), while the anion is always bis(trifluoromethanesulfonyl)imide (TFSI). We find that the self-diffusivity of the individual ionic species is correlated to the local structure in the corresponding ionic liquid, namely the nano-segregation into polar and non-polar domains. In agreement with previous results, we observe that for relatively short alkyl chains the cations diffuse faster than the anions; however we also note that this difference becomes less evident for longer alkyl chains and a cross-over is identified at n 鈮?8 with the anions diffusing faster than the cations. Our results indicate that this controversial behavior can be rationalized in terms of different types of cation-cation and anion-anion orderings, as revealed by a detailed anal. of the correlation lengths and their dispersion curves obtained from SAXS data. We also discuss the validity of the Stokes-Einstein relation for these ionic liquids and the evolution of the extrapolated cationic radius that was found to depend non-strictly linearly on n, in agreement with the cation-cation correlation lengths. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Category: imidazoles-derivatives).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quaternization of azido-N-heteroarenes with Meerwein reagent: A straightforward synthesis of 2-azido(benzo)imidazolium and related azido-N-heteroarenium tetrafluoroborates was written by Li, Yan;Wan, Ting-Biao;Guo, Bin;Qi, Xiao-Wen;Zhu, Chifan;Shen, Mei-Hua;Xu, Hua-Dong. And the article was included in Tetrahedron Letters in 2022.Category: imidazoles-derivatives This article mentions the following:

The 2-azido(benzo)imidazolium salts e.g., I have been made through quaternization of 2-Azido(benzo)imidazoles e.g., II with Meerwein reagent at ambient conditions. This one-pot protocol is also applicable to 4 or 3-azidopyridines e.g., III and appropriate azido(iso)quinolines e.g., IV to prepare correlative azido-N-heteroarenium salts e.g., I. When compared with their precursors, improved diazotransfer reactivity was observed for several representative azido-N-heteroarenium salts e.g., I in reaction with di-Et malonate. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dynamic conformational and exchange processes in 2-(4′-pyridyl)benzazoles was written by Marzin, Claude;Peek, Michael E.;Elguero, Jose;Figeys, Hubert P.;Defay, Nicole. And the article was included in Heterocycles in 1977.COA of Formula: C9H8N2O This article mentions the following:

The rotational barrier about the C-C bond linking the heterocyclic ring systems in I (X = NH, NMe, NPh, O, S; Q = CH, N; R = Me, H), II, and III (R = H, Me; X = NH, NMe, NPh, O, S) were determined by 1H NMR. The H-exchange reaction in I (Q = CH, X = NH, R = H, Me) was slow enough to be observed in both 13C and 1H NMR as peak broadenings. The conformations of the heterocyclic ring systems are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4COA of Formula: C9H8N2O).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C9H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Manganese-Catalyzed Hydroborations with Broad Scope was written by Ghosh, Pradip;Jacobi von Wangelin, Axel. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 1-Methylbenzimidazole This article mentions the following:

Reductive transformations of easily available oxidized matter are at the heart of synthetic manipulation and chem. valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C:X electrophiles. Here, the authors report an especially facile, broad-scope reduction of various functions including carbonyls, carboxylates, pyridines, carbodiimides, and carbonates under very mild conditions with the inexpensive pre-catalyst Mn(hmds)₂. The reaction could be successfully applied to depolymerizations In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Recommanded Product: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents was written by Wang, Rubing;Chen, Chengsheng;Zhang, Xiaojie;Zhang, Changde;Zhong, Qiu;Chen, Guanglin;Zhang, Qiang;Zheng, Shilong;Wang, Guangdi;Chen, Qiao-Hong. And the article was included in Journal of Medicinal Chemistry in 2015.Reference of 3012-80-4 This article mentions the following:

Forty-three 1,5-diheteroaryl-1,4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen-containing aromatic rings. They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step and evaluated for their cytotoxicity and antiproliferative activities toward both androgen-insensitive and androgen-sensitive prostate cancer cell lines and an aggressive cervical cancer cell line. Most of the synthesized compounds showed distinctly better in vitro potency than curcumin in the four cancer cell lines. The structure-activity data acquired from the study validated (1E,4E)-1,5-diheteroaryl-1,4-pentadien-3-ones as an excellent scaffold for in-depth development for clin. treatment of prostate and cervical cancers. 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazol-2-yl, and 2-methyl-4-(trifluoromethyl)thiazol-5-yl were identified as optimal heteroaromatic rings for the promising in vitro potency. (1E,4E)-1,5-Bis(2-methyl-4-(trifluoromethyl)thiazol-5-yl)penta-1,4-dien-3-one, featuring thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of its good in vitro potency and attractive in vivo pharmacokinetic profiles. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Reference of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation, characterization and ex vivo-in vivo assessment of candesartan cilexetil nanocrystals via solid dispersion technique using an alkaline esterase activator carrier was written by Amer, Ahmed M.;Allam, Ahmed N.;Abdallah, Ossama Y.. And the article was included in Drug Development and Industrial Pharmacy in 2019.HPLC of Formula: 145040-37-5 This article mentions the following:

The objective of this study was to improve candesartan cilexetil (CC) efficacy by formulating nanocrystals via solid dispersion (SD) technique using tromethamine (Tris). SD was prepared by solvent evaporation at different drug carrier ratios, evaluated for particle size, vitro dissolution studies, TEM, FTIR, and X-ray powder diffraction. Ex vivo, in vivo pharmacokinetic parameters were conducted on selected formulas compared to drug suspension and marketed product. Size anal. demonstrated formation of particles in the nanorange lower than 300 nm. A burst drug release followed by an improved dissolution was observed indicating instant formation of nanocrystals along with amorphization as confirmed by X-ray diffraction. FTIR studies suggested the absence of chem. interaction between Tris and CC. TEM revealed formation of irregular oval nanoparticles. SD-1:5 has higher apparent permeability coefficient compared to CC suspension. Furthermore, the pharmacokinetic results proved the ability of the formed nanoparticles to enhance the efficacy of CC compared to drug suspension and marketed product. In conclusion, using of Tris as alk. esterase activator carrier could be a promising tool to bypass the controversial effect of esterase enzymes that may be a source for inter-individual variations affecting ester prodrug candidates’ efficacy. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5HPLC of Formula: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. HPLC of Formula: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Probing the cannabinoid CB₁/CB₂ receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern was written by Lange, Jos H. M.;van der Neut, Martina A. W.;Borst, Alice J. M.;Yildirim, Mahmut;van Stuivenberg, Herman H.;van Vliet, Bernard J.;Kruse, Chris G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 1H-Imidazole-4-carboxamide This article mentions the following:

The cannabinoid CB₁/CB₂ receptor subtype selectivity in the 1,2-diarylimidazole-4-carboxamide series was boosted by fine-tuning its 5-substitution pattern. The presence of the 5-methylsulfonyl group in 11 led to a greater than 鈭?40-fold CB₁/CB₂ subtype selectivity. The compounds 10, 18 and 19 were found more active than rimonabant (1) in a CB₁-mediated rodent hypotension model after oral administration. Our findings suggest a limited brain exposure of the P-glycoprotein substrates 11, 12 and 21. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Recommanded Product: 1H-Imidazole-4-carboxamide).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 1H-Imidazole-4-carboxamide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydration properties of glycylglycine in aqueous ionic liquid solutions at different temperatures: Volumetric and acoustic approach was written by Gaba, Rekha;Pal, Amalendu;Sharma, Dinkar;Amirchand Khajuria, Deepika. And the article was included in Journal of Molecular Liquids in 2017.Synthetic Route of C4H7ClN2 This article mentions the following:

The apparent molar volume and isentropic compression of glycylglycine in aqueous 1-methylimidazolium chloride, [mim][Cl], 1-ethyl-3-methylimidazolium chloride [C₂mim][Cl], and 1-methyl-3-octylimidazolium chloride [C₈mim][Cl] solutions have been calculated from the measured exptl. data on d. and speed of sound at temperature, T = 288.15, 298.15 and 308.15 K. The apparent molar volumes at infinite dilution, V⁰_蠒 and the apparent isentropic molar compression at infinite dilution K⁰_蠒聽_,聽_S, were also calculated Furthermore, apparent sp. volumes, apparent molar expansivity, E⁰_蠒, Hepler’s constant values, (((鈭?em>E⁰_蠒)/(鈭?em>T)))_P and hydration numbers, n_H, have been evaluated to support the conclusions obtained from the volumetric and acoustic studies. The Hepler’s constant values were found neg. which indicating the peptide under study is predominantly a structure breaker due to hydrophobic hydration of small peptide in aqueous ionic liquid In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem