Synthesis and antiaggregant and anticoagulant activity of new 1-(4-alkyloxybenzyl)-1H-azoles and 1-(adamantyl-1)-2-[4-(1H-azol-1-ylmethyl)-phenoxy]ethanones was written by Gurevich, K. G.;Urakov, A. L.;Basantsev, A. V.;Abzalilov, T. A.;Bashirov, I. I.;Danilin, A. A.;Purygin, P. P.;Golovanov, A. A.;Khayrzamanova, K. A.;Samorodov, A. V.. And the article was included in Pharmaceutical Chemistry Journal in 2021.Category: imidazoles-derivatives This article mentions the following:
The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols I [R = n-octyl, n-hexadecyl, 1-adamantyl; Az = imidazol-1-ylmethyl, 1,2,4-triazol-1-ylmethyl, benzimidazol-1-ylmethyl, benzotriazol-1-ylmethyl] enabled the expansion of organic synthesis methodol., which is extremely important for designing new structures with various types of biol. activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental anal. and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem