peri-Substituted imidazo[1,2-a]pyridines. A new reductive elimination reaction was written by Rees, Charles W.;Smith, David I.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Safety of 5-Bromoimidazo[1,2-a]pyridine This article mentions the following:
A new reductive elimination reaction of 3,5-disubstituted imidazo[1,2-a]pyridines I (R, R1 = Br, NO2) with N2H4 in hot EtOH is reported. A mechanism based on the conjugated relationship of these peri-substituents is proposed and used to explain the reported conversion of 1,3,5-trichloro-2,4,6-trinitrobenzene into 1,3-dichloro-4,6-dinitrobenzene. A variety of other 3-nitro-5-substituted imidazo[1,2-a]pyridines I (R = NO2, R1 = CO2Me, CONHNH2, CON3, NH2, NHCO2Me, N3, etc.) are described, but these could not be cyclized. The 3-amino-5-methoxycarbonyl derivative I (R = NH2, R1 = CO2Me) cyclizes to the imidazoindazole II with NaOMe. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Safety of 5-Bromoimidazo[1,2-a]pyridine).
5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 5-Bromoimidazo[1,2-a]pyridine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem