Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity was written by Yang, Wen-Chao;Li, Jing;Li, Jun;Chen, Qiong;Yang, Guang-Fu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Related Products of 26832-08-6 This article mentions the following:
A novel synthetic method for N-cyanoimidazolecarboxamides has been developed with advantages of mild reaction conditions, simpler procedure, and easy reactant-product isolation compared with the existing methods. Thus, a one-step or two-step alkylation of 8-methylimidazo[1,5-d][1,2,4]triazin-1-(2H)-one gave N-cyanocarboxamides. Using this novel method, 16 new N-cyano-1H-imidazole-4-carboxamide derivatives were synthesized and their structures were characterized by spectrum anal. Further antifungal activity study showed that most of the newly synthesized compounds have good antifungal activity selectively against Rhizoctonia solani among the six fungi tested. Particularly, compound I was identified as the most promising candidate with an EC50 of 2.63 μg/mL against R. solani. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Related Products of 26832-08-6).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 26832-08-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem