Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions was written by Araki, Shota;Wakabayashi, Rie;Moniruzzaman, Muhammad;Kamiya, Noriho;Goto, Masahiro. And the article was included in MedChemComm in 2015.Computed Properties of C18H31F6N3O4S2 This article mentions the following:
As a potentially safe and non-invasive vaccination method, transcutaneous immunization represents an attractive alternative to conventional vaccine delivery by injection. However, the development of transcutaneous immunization has remained a challenge for a large number of hydrophilic macromols. including protein and peptide antigens. We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil (S/O) nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of the IL [C12mim][Tf2N] (1-dodecyl-3-Me imidazolium bis(trifluoromethyl sulfonyl) amide) as a penetration enhancer in the formulation significantly enhanced the skin permeability of ovalbumin (OVA), a model antigen. It was also found that the IL-mediated S/O nanodispersion obtained high levels of OVA-specific serum IgG compared with both S/O nanodispersions without IL and PBS control. These findings clearly indicate that ILs – which are potentially attractive “green” and “designer” solvents – could serve as potential skin penetration enhancers in transcutaneous vaccination for hydrophilic macromols. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Computed Properties of C18H31F6N3O4S2).
3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C18H31F6N3O4S2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem