Gurbuz, Nevin et al. published their research in Journal of Organometallic Chemistry in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 1-Methylbenzimidazole

Silver(I) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties was written by Gurbuz, Nevin;Kaloglu, Nazan;Kizrak, Umran;Ozdemir, Ilknur;Turkmen, Nese Basak;Ciftci, Osman;Ozdemir, Ismail;Mansour, L.;Naceur, Hamdi. And the article was included in Journal of Organometallic Chemistry in 2020.Quality Control of 1-Methylbenzimidazole This article mentions the following:

Sulfonate functionalized N-heterocyclic carbene ligand precursors were obtained from the compounds 1-alkylbenzimidazole, 1,3-propane sultone, and 1,4-butane sultone. These NHC ligand precursors were metalated with Ag2O on moderate conditions to give novel Ag-NHC complexes. All new compounds were characterized by 1H NMR, 13C NMR, FTIR and elemental anal. techniques. The cytotoxic properties of the Ag(I) complexes were assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTT based assay on three human cell lines brain (SHSY5Y) and liver (HEP3B). These Ag N-heterocyclic carbene complexes were highlighted metal-based cancer therapeutic agents with unique structures and functions. These strategies provide exciting opportunities for discovering new types of metallodrugs. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Quality Control of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem