Catalytic synthesis of benzimidazole and its derivatives was written by Kozlov, N. S.;Tovshtein, M. N.. And the article was included in Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk in 1967.Formula: C15H22N2 This article mentions the following:
A new synthesis of the title compounds (I) was described. A mixture of o-O2NC6H4NH2 and the appropriate alc. in the molar ratio 1:3 or 1:6 was passed at a volume speed 0.3 hr.-1 over a catalyst (40 ml.) of V and Cu on Al2O3 heated to 320° and the product filtered off or in the case of excess alc. the solvent was evaporated and the residue fractionated in vacuo to give I (R, m.p. given): H, 170°; Me, 175°; Et, 179°; Pr, 158°; Bu, 148°; amyl, 159°; hexyl, 134°; heptyl, 141°; octyl, 137°; nonyl, 124°; Ph, 290°. Aldehydes formed as by-products could be isolated by distillation or as oximes. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Formula: C15H22N2).
2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C15H22N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem