Synthesis of new hypoxia markers EF1 and [18F]-EF1 was written by Kachur, Alexander V.;Dolbier, William R. Jr.;Evans, Sydney M.;Shiue, Chyng-Yann;Shiue, Grace G.;Skov, Kirsten A.;Baird, Ian R.;James, Brian R.;Li, An-Rong;Roche, Alex;Koch, Cameron J.. And the article was included in Applied Radiation and Isotopes in 1999.Name: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:
We report on the preparation of a hypoxia marker 2-(2-nitroimidazol-1[H]-yl)-N-(3-fluoropropyl)acetamide (EF1, I) and its 18F analog. Two methods for the preparation of 3-fluoropropylamine, the EF1 side chain, are described. [18F]-EF1 was prepared with a radiochem. yield of 2% by nucleophilic substitution of bromine in 2-(2-nitroimidazol-1[H]-yl)-N-(3-bromopropyl)acetamide (EBr1) by carrier-added 18F in DMSO at 120°. Our results demonstrate the preparation of clin. relevant amounts of [18F]-EF1 for use as a non-invasive hypoxia marker with detection using positron emission tomog. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Name: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem