Inhibitors of hepatic mixed function oxidases. II. Some benzimidazole, benzoxazole and benzothiazole derivatives was written by Holder, Gerald M.;Little, Peter J.;Ryan, Adrian J.;Watson, Thomas R.. And the article was included in Biochemical Pharmacology in 1976.Recommanded Product: 2-Octylbenzimidazole This article mentions the following:
Aminopyrine N-demethylase [9037-69-8] activity in rat liver microsomes was inhibited by 19 benzimidazole derivatives (e.g. I [615-15-6]), 2 benzoxazole derivatives, and 2 benzothiazole derivatives with 50% inhibitory concentrations (I50) ranging from 1.5 × 10-5M to 108 × 10-5M. Aniline p-hydroxylase [9012-80-0] activity was inhibited by all but 4 of these compounds, with I50 from 16 × 10-5M to 360 × 10-5M, and was stimulated by 3 of the compounds The I50 decreased with increasing lipophilicity caused by extension of the alkyl side chain and modification of the heterocyclic ring. The I50s for inhibition of each enzyme were correlated with the octanol/water partition coefficient of the compounds Quinalbarbitone [309-43-3] sleeping time in mice was increased by 14 out of 16 of the compounds tested. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Recommanded Product: 2-Octylbenzimidazole).
2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 2-Octylbenzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem