Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling was written by Firmansyah, Dikhi;Banasiewicz, Marzena;Gryko, Daniel T.. And the article was included in Organic & Biomolecular Chemistry in 2015.Synthetic Route of C7H5BrN2 This article mentions the following:
The anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles e. g., I, in reasonable yields. The yield of the key step (K, toluene, O2) depends on both electronic and steric factors. The whole strategy consists of just two steps starting from an unsubstituted imidazo[1,2-a]pyridine, giving target compounds in an overall yield of 4-34%. The same strategy also works for derivatives of imidazo[1,5-a]pyridine. A new process has been discovered for such vertically-expanded imidazo[1,2-a]pyridines, consisting of a sequential Diels-Alder reaction followed by a retro-Diels-Alder reaction. The optical properties of the library of π-expanded imidazo[1,2-a]pyridines were for the first time fully characterized, showing that fluorescence quantum yields are significantly lower than for the singly-linked compounds In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Synthetic Route of C7H5BrN2).
5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C7H5BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem