Effect of salt formation on γ-cyclodextrin solubilization of irbesartan and candesartan and the chemical stability of their ternary complexes was written by Jansook, Phatsawee;Hnin, Hay Marn;Praphanwittaya, Pitsiree;Loftsson, Thorsteinn;Stefansson, Einar. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Electric Literature of C33H34N6O6 This article mentions the following:
Angiotensin II receptor blockers (ARBs) are unstable compounds and have relatively low aqueous solubility, which may hamper their bioavailability. The present study aimed to increase the aqueous solubility of ARBs by the formation of cyclodextrin (CD) inclusion complex and determine their chem. stability in aqueous solutions The pH- solubility of drugs and their phase-solubility profiles were determined, and the results showed that the solubility of drugs increased by forming inclusion complexes with γ-cyclodextrin (γCD) and by increasing their intrinsic solubility in phosphate buffer (pH 7.5). The formation of irbesartan/γCD (IRB/γCD) and candesartan cilexetil/γCD (CAC/γCD) inclusion complexes was confirmed by mol. docking. To enhance the γCD solubilization of drugs, salt formation using various organic salts was also investigated. Of these, Tris was the most powerful, followed by sodium acetate, as they significantly increased the γCD solubilization of IRB and CAC. However, chem. instability was observed, particularly at high salt concentrations, where they provided a higher IRB and CAC solubility Thus, the balance of optimum drug solubility and its chem. stability in aqueous solutions should be considered in formulation development. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C33H34N6O6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem